BLOC1S2 and CCDC146

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		BLOC1S2	CCDC146
Name		biogenesis of lysosomal organelles complex 1 subunit 2	coiled-coil domain containing 146
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Gamma-tubulin Complex Nucleus Cytoplasm Mitochondrion Lysosome Lysosomal Membrane Centrosome Cytosol Cytoskeleton Membrane BLOC-1 Complex Cytoplasmic Side Of Lysosomal Membrane BORC Complex Axon Cytoplasm	Cytoplasm Centrosome Centriole Cytoskeleton Cilium Axoneme Midbody Motile Cilium Ciliary Basal Body Sperm Flagellum Cell Projection Sperm Head-tail Coupling Apparatus
	Molecular Function	Protein Binding Gamma-tubulin Binding	Protein Binding Protein-containing Complex Binding
	Biological Process	Microtubule Nucleation Anterograde Axonal Transport Positive Regulation Of Cell Population Proliferation Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Endosomal Transport Neuron Projection Development Lysosome Localization Melanosome Organization Positive Regulation Of DNA-templated Transcription Anterograde Synaptic Vesicle Transport Regulation Of Endosome Size Platelet Dense Granule Organization Regulation Of Lysosome Size Organelle Transport Along Microtubule Mitochondrial Outer Membrane Permeabilization	Cell Morphogenesis Nucleus Organization Spermatogenesis Spermatid Development Sperm Axoneme Assembly Single Fertilization Cell Population Proliferation Gene Expression Cell Differentiation Flagellated Sperm Motility Cilium Organization Sperm Flagellum Assembly Manchette Assembly
GWAS		Refractive error ( 32231278 )	Amyloid beta positivity ( 34154648 ) Appendicular lean mass ( 33097823 ) Body mass index ( 28892062 ) Macrovascular complications in type 2 diabetes ( 33430853 ) Ophthalmic complications in type 2 diabetes ( 33430853 ) Response to amphetamines ( 22952603 )
Interacting Genes		36 interacting genes: APP ARFIP2 BFSP2 BLOC1S1 BLOC1S3 BLOC1S4 BLOC1S5 BLOC1S6 C8orf33 CCDC146 CCHCR1 CCNC CTNNA3 DCTN2 ERP27 EXOC8 FAM161B FAM9B GADD45G GEM HMOX2 KRT26 MEST P4HA3 PAM16 PICK1 RDH11 SH2D4A SNAPIN SSC5D STX2 TNNT1 TRIML2 TTC3 WASHC1 WASHC3	71 interacting genes: AKAP9 BLOC1S2 CBY2 CCDC136 CCDC197 CCNDBP1 CDR2 CDR2L CENPH CEP170P1 CEP44 CFTR DRC4 DTNBP1 FSD2 GOLGA2 GOLGA6L9 GPRASP2 GRAMD4 HSF2BP INSYN1 KIFC3 KRT16 KRT18 KRT19 KRT24 KRT26 KRT27 KRT31 KRT34 KRT38 KRT40 KRT86 LHX3 MAGEA11 MAGEA6 MCC MED4 MIPOL1 MRFAP1 MTUS2 N4BP3 NAP1L2 NECAB2 NINL NUP62 PDE4DIP PLEKHF2 PNMA1 PPP2R3C PROSER3 PSMC6 RINT1 RNF40 RPGRIP1 SH3BP1 SYCE1L TEPSIN TFIP11 THOC7 TNR TPM3 TRAF1 TRIM23 TRIM54 TRIML2 TSC22D4 TXLNA USHBP1 VPS28 VPS52
Entrez ID		282991	57639
HPRD ID		12526	11150
Ensembl ID		ENSG00000196072	ENSG00000135205
Uniprot IDs		A0A087X1N6 F1T0F0 Q6QNY1	Q8IYE0 Q96MS1
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Anterograde Synaptic Vesicle Transport BLOC-1 Complex Synaptic Vesicle Transport Melanosome Organization Pigment Granule Organization Axo-dendritic Transport Anterograde Axonal Transport Vesicle Transport Along Microtubule Vesicle Cytoskeletal Trafficking Establishment Of Vesicle Localization Axon Cytoplasm Axonal Transport Vesicle Localization Organelle Localization Organelle Transport Along Microtubule Intracellular Transport Transport Along Microtubule Melanosome Transport Cellular Localization Establishment Of Melanosome Localization Pigment Granule Transport Cytoskeleton-dependent Intracellular Transport Establishment Of Localization In Cell Melanosome Localization Pigment Granule Localization Vesicle Organization Regulation Of Arp2/3 Complex-mediated Actin Nucleation Microtubule-based Transport Microvesicle Regulation Of Actin Nucleation Plasma Membrane Bounded Cell Projection Organization Endosome To Melanosome Transport Microtubule-based Movement Establishment Of Organelle Localization Protein Transport Cell Projection Organization Secretion By Cell Organelle Organization Membrane Curvature Sensor Activity Microtubule-based Process Establishment Of Protein Localization Secretion Of Lysosomal Enzymes Neuron Projection Development Exocytosis Positive Regulation Of Pigment Cell Differentiation Secretion Regulation Of Lysosome Size BORC Complex Positive Regulation Of Developmental Pigmentation Pigmentation	Structural Constituent Of Skin Epidermis Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process Intermediate Filament Organization Intermediate Filament Cytoskeleton Organization Cytoskeleton Structural Molecule Activity Organelle Organization Supramolecular Fiber Organization Epithelial Cell Differentiation Microtubule-based Process Protein Binding Morphogenesis Of An Epithelium Centrosome Cycle Tissue Morphogenesis Microtubule Nucleation Centrosome Microtubule Organizing Center Organization Microtubule Cytoskeleton Organization Microtubule Binding Vesicle Transport Along Microtubule