BLOC1S2 and RDH11

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		BLOC1S2	RDH11
Description		biogenesis of lysosomal organelles complex 1 subunit 2	retinol dehydrogenase 11
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Gamma-tubulin Complex Nucleus Cytoplasm Mitochondrion Lysosome Lysosomal Membrane Centrosome Cytosol Cytoskeleton Membrane BLOC-1 Complex Cytoplasmic Side Of Lysosomal Membrane BORC Complex Axon Cytoplasm	Photoreceptor Inner Segment Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Protein Binding Gamma-tubulin Binding	All-trans-retinol Dehydrogenase (NAD+) Activity Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Aldehyde Dehydrogenase (NADP+) Activity All-trans-retinol Dehydrogenase (NADP+) Activity 11-cis-retinol Dehydrogenase (NADP+) Activity
	Biological Process	Microtubule Nucleation Anterograde Axonal Transport Positive Regulation Of Cell Population Proliferation Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Endosomal Transport Neuron Projection Development Lysosome Localization Melanosome Organization Positive Regulation Of DNA-templated Transcription Anterograde Synaptic Vesicle Transport Regulation Of Endosome Size Platelet Dense Granule Organization Regulation Of Lysosome Size Organelle Transport Along Microtubule Mitochondrial Outer Membrane Permeabilization	Retinoid Metabolic Process Lipid Metabolic Process Visual Perception Retinol Metabolic Process Retinal Metabolic Process Cellular Detoxification Of Aldehyde
Pathways			The canonical retinoid cycle in rods (twilight vision) RA biosynthesis pathway Retinoid metabolism and transport
Drugs			Vitamin A
Diseases
GWAS		Refractive error ( 32231278)
Interacting Genes		36 interacting genes: APP ARFIP2 BFSP2 BLOC1S1 BLOC1S3 BLOC1S4 BLOC1S5 BLOC1S6 C8orf33 CCDC146 CCHCR1 CCNC CTNNA3 DCTN2 ERP27 EXOC8 FAM161B FAM9B GADD45G GEM HMOX2 KRT26 MEST P4HA3 PAM16 PICK1 RDH11 SH2D4A SNAPIN SSC5D STX2 TNNT1 TRIML2 TTC3 WASHC1 WASHC3	5 interacting genes: BLOC1S2 CA12 ROBO2 SELENOF TMEM31
Entrez ID		282991	51109
HPRD ID		12526	09707
Ensembl ID		ENSG00000196072	ENSG00000072042
Uniprot IDs		A0A087X1N6 F1T0F0 Q6QNY1	A0A0S2Z583 Q8TC12
PDB IDs
Enriched GO Terms of Interacting Partners?		Anterograde Synaptic Vesicle Transport BLOC-1 Complex Synaptic Vesicle Transport Melanosome Organization Pigment Granule Organization Axo-dendritic Transport Anterograde Axonal Transport Vesicle Transport Along Microtubule Vesicle Cytoskeletal Trafficking Establishment Of Vesicle Localization Axon Cytoplasm Axonal Transport Vesicle Localization Organelle Localization Organelle Transport Along Microtubule Intracellular Transport Transport Along Microtubule Melanosome Transport Cellular Localization Establishment Of Melanosome Localization Pigment Granule Transport Cytoskeleton-dependent Intracellular Transport Establishment Of Localization In Cell Melanosome Localization Pigment Granule Localization Vesicle Organization Regulation Of Arp2/3 Complex-mediated Actin Nucleation Microtubule-based Transport Microvesicle Regulation Of Actin Nucleation Plasma Membrane Bounded Cell Projection Organization Endosome To Melanosome Transport Microtubule-based Movement Establishment Of Organelle Localization Protein Transport Cell Projection Organization Secretion By Cell Organelle Organization Membrane Curvature Sensor Activity Microtubule-based Process Establishment Of Protein Localization Secretion Of Lysosomal Enzymes Neuron Projection Development Exocytosis Positive Regulation Of Pigment Cell Differentiation Secretion Regulation Of Lysosome Size BORC Complex Positive Regulation Of Developmental Pigmentation Pigmentation	Chloride Ion Homeostasis Estrous Cycle Carbonate Dehydratase Activity Ovulation Cycle Negative Regulation Of Negative Chemotaxis Olfactory Bulb Interneuron Development Endocardial Cushion Formation Apoptotic Process Involved In Luteolysis Heart Induction Axon Guidance Receptor Activity Negative Regulation Of Synapse Organization Axon Midline Choice Point Recognition Regulation Of Negative Chemotaxis Axon Choice Point Recognition Negative Regulation Of Synapse Assembly Pulmonary Valve Morphogenesis Regulation Of Heart Morphogenesis Axolemma Selenium Binding Sperm DNA Condensation 'de Novo' Post-translational Protein Folding 'de Novo' Protein Folding Thioredoxin Peroxidase Activity Anterograde Synaptic Vesicle Transport Gamma-tubulin Complex Regulation Of Endosome Size Cytoplasmic Side Of Lysosomal Membrane Regulation Of Lysosome Size Positive Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Mitochondrial Outer Membrane Permeabilization Involved In Programmed Cell Death Regulation Of Vesicle Size BORC Complex BLOC-1 Complex Mitochondrial Outer Membrane Permeabilization Monoatomic Anion Homeostasis Retinal Ganglion Cell Axon Guidance Forebrain Neuron Development Organ Induction Platelet Dense Granule Organization Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Neuron Projection Development Outflow Tract Septum Morphogenesis Positive Regulation Of Mitochondrial Membrane Permeability
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