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ANAPC11 and KRTAP19-2
Data Source:
BioGRID
(two hybrid)
ANAPC11
KRTAP19-2
Description
anaphase promoting complex subunit 11
keratin associated protein 19-2
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Anaphase-promoting Complex
Nucleolus
Cytosol
Cullin-RING Ubiquitin Ligase Complex
Cytosol
Intermediate Filament
Molecular Function
Ubiquitin-protein Transferase Activity
Protein Binding
Zinc Ion Binding
Ubiquitin-ubiquitin Ligase Activity
Ubiquitin Protein Ligase Activity
Cullin Family Protein Binding
Protein Binding
Biological Process
Mitotic Cell Cycle
Ubiquitin-dependent Protein Catabolic Process
Protein Ubiquitination
Anaphase-promoting Complex-dependent Catabolic Process
Positive Regulation Of Mitotic Metaphase/anaphase Transition
Cell Division
Protein K11-linked Ubiquitination
Regulation Of Mitotic Cell Cycle Phase Transition
Keratinization
Pathways
Inactivation of APC/C via direct inhibition of the APC/C complex
APC/C:Cdc20 mediated degradation of Cyclin B
Autodegradation of Cdh1 by Cdh1:APC/C
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
Regulation of APC/C activators between G1/S and early anaphase
APC/C:Cdc20 mediated degradation of mitotic proteins
Phosphorylation of the APC/C
APC-Cdc20 mediated degradation of Nek2A
Separation of Sister Chromatids
Senescence-Associated Secretory Phenotype (SASP)
CDK-mediated phosphorylation and removal of Cdc6
Transcriptional Regulation by VENTX
Aberrant regulation of mitotic exit in cancer due to RB1 defects
Antigen processing: Ubiquitination & Proteasome degradation
Keratinization
Drugs
Diseases
GWAS
Interacting Genes
55 interacting genes:
ANAPC10
ANAPC2
ANAPC4
BANP
BEND2
CAPN11
CCNB1
CDC16
CDC20
CREB5
CRYBA2
CUL5
CYSRT1
DTX2
EFEMP1
EFEMP2
FBXO5
FRS3
FZR1
GPANK1
HSD3B7
IQUB
KRTAP11-1
KRTAP13-2
KRTAP19-2
KRTAP3-1
KRTAP3-3
KRTAP6-1
KRTAP6-2
MAK
MGAT5B
MLKL
NKD2
OXER1
P4HA3
PRKAA2
PRKAB2
PTTG1
RBPMS
RNF111
TCEANC
TEX37
TLE5
TRIM65
UBC
UBE2C
UBE2D1
UBE2D2
UBE2D3
UBE2K
UBE2L1
UBE2S
UBE2U
WWOX
ZAP70
46 interacting genes:
ADAMTSL4
ANAPC11
ATN1
C11orf16
CHRD
COL8A1
CREB5
CYSRT1
EFEMP1
ETHE1
FBLN1
FOXD2
FOXH1
GNE
HOXC8
HSD3B7
KPRP
KRTAP12-2
KRTAP12-4
KRTAP3-3
KRTAP4-12
KRTAP6-3
KRTAP9-3
LCE2D
MEIS2
MGAT5B
MKRN3
NTAQ1
OLIG3
OTX1
PCSK5
PIGS
POU4F2
RHBG
SLC12A4
SLC15A3
SMARCC1
SNRPC
SPAG8
TEKT4
TENT5D
TFAP2D
VENTX
VGLL3
VWC2L
ZIC1
Entrez ID
51529
337969
HPRD ID
12452
11206
Ensembl ID
ENSG00000141552
ENSG00000186965
Uniprot IDs
A0A024R8S1
Q9NYG5
Q3LHN2
PDB IDs
2MT5
4R2Y
4UI9
5A31
5G04
5G05
5JG6
5KHR
5KHU
5L9T
5L9U
5LCW
6Q6G
6Q6H
6TLJ
6TM5
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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