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ANAPC11 and UBE2S
Data Source:
BioGRID
(pull down)
ANAPC11
UBE2S
Description
anaphase promoting complex subunit 11
ubiquitin conjugating enzyme E2 S
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Anaphase-promoting Complex
Nucleolus
Cytosol
Cullin-RING Ubiquitin Ligase Complex
Nucleus
Nucleoplasm
Anaphase-promoting Complex
Cytosol
Molecular Function
Ubiquitin-protein Transferase Activity
Protein Binding
Zinc Ion Binding
Ubiquitin-ubiquitin Ligase Activity
Ubiquitin Protein Ligase Activity
Cullin Family Protein Binding
Ubiquitin-protein Transferase Activity
Protein Binding
ATP Binding
Anaphase-promoting Complex Binding
Ubiquitin Conjugating Enzyme Activity
Biological Process
Mitotic Cell Cycle
Ubiquitin-dependent Protein Catabolic Process
Protein Ubiquitination
Anaphase-promoting Complex-dependent Catabolic Process
Positive Regulation Of Mitotic Metaphase/anaphase Transition
Cell Division
Protein K11-linked Ubiquitination
Regulation Of Mitotic Cell Cycle Phase Transition
Protein Polyubiquitination
Cellular Protein Modification Process
Ubiquitin-dependent Protein Catabolic Process
Exit From Mitosis
Free Ubiquitin Chain Polymerization
Protein Ubiquitination
Anaphase-promoting Complex-dependent Catabolic Process
Protein K29-linked Ubiquitination
Protein K27-linked Ubiquitination
Cell Division
Protein K63-linked Ubiquitination
Protein K11-linked Ubiquitination
Protein K6-linked Ubiquitination
Positive Regulation Of Ubiquitin Protein Ligase Activity
Pathways
Inactivation of APC/C via direct inhibition of the APC/C complex
APC/C:Cdc20 mediated degradation of Cyclin B
Autodegradation of Cdh1 by Cdh1:APC/C
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
Regulation of APC/C activators between G1/S and early anaphase
APC/C:Cdc20 mediated degradation of mitotic proteins
Phosphorylation of the APC/C
APC-Cdc20 mediated degradation of Nek2A
Separation of Sister Chromatids
Senescence-Associated Secretory Phenotype (SASP)
CDK-mediated phosphorylation and removal of Cdc6
Transcriptional Regulation by VENTX
Aberrant regulation of mitotic exit in cancer due to RB1 defects
Antigen processing: Ubiquitination & Proteasome degradation
Inactivation of APC/C via direct inhibition of the APC/C complex
APC/C:Cdc20 mediated degradation of Cyclin B
Autodegradation of Cdh1 by Cdh1:APC/C
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
Regulation of APC/C activators between G1/S and early anaphase
APC/C:Cdc20 mediated degradation of mitotic proteins
Phosphorylation of the APC/C
APC-Cdc20 mediated degradation of Nek2A
Separation of Sister Chromatids
Senescence-Associated Secretory Phenotype (SASP)
CDK-mediated phosphorylation and removal of Cdc6
Transcriptional Regulation by VENTX
Synthesis of active ubiquitin: roles of E1 and E2 enzymes
Aberrant regulation of mitotic exit in cancer due to RB1 defects
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS
Interacting Genes
55 interacting genes:
ANAPC10
ANAPC2
ANAPC4
BANP
BEND2
CAPN11
CCNB1
CDC16
CDC20
CREB5
CRYBA2
CUL5
CYSRT1
DTX2
EFEMP1
EFEMP2
FBXO5
FRS3
FZR1
GPANK1
HSD3B7
IQUB
KRTAP11-1
KRTAP13-2
KRTAP19-2
KRTAP3-1
KRTAP3-3
KRTAP6-1
KRTAP6-2
MAK
MGAT5B
MLKL
NKD2
OXER1
P4HA3
PRKAA2
PRKAB2
PTTG1
RBPMS
RNF111
TCEANC
TEX37
TLE5
TRIM65
UBC
UBE2C
UBE2D1
UBE2D2
UBE2D3
UBE2K
UBE2L1
UBE2S
UBE2U
WWOX
ZAP70
42 interacting genes:
AKT1
ANAPC1
ANAPC11
ANAPC2
ANAPC4
ANAPC5
ANAPC7
APP
ATXN3
BIRC2
CCNB1
CDC16
CDC20
CDC23
CDC27
CTNNB1
CYLD
FBXO5
FZR1
GMNN
HERC1
LINC00839
MDM2
OTUB1
OTUD7B
PRKN
PTEN
RBCK1
RNF7
STAMBP
UBA1
UBA6
UBB
UBC
UCHL3
USP15
USP2
USP21
USP5
USP7
VHL
ZRANB1
Entrez ID
51529
27338
HPRD ID
12452
15603
Ensembl ID
ENSG00000141552
ENSG00000108106
Uniprot IDs
A0A024R8S1
Q9NYG5
Q16763
PDB IDs
2MT5
4R2Y
4UI9
5A31
5G04
5G05
5JG6
5KHR
5KHU
5L9T
5L9U
5LCW
6Q6G
6Q6H
6TLJ
6TM5
1ZDN
5BNB
5L9T
6QH3
6QHK
6S96
6S98
Enriched GO Terms of Interacting Partners
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