ITGA6

Name	integrin subunit alpha 6
Structure
Interactors	23 interactors: ADAM9 APP BIN1 CALM1 CANX CD151 CD36 CD63 CD82 COL17A1 GIPC1 GRB2 ITGB1 ITGB4 LGALS3BP PCSK5 PLEC PRKCD PXN RABIF RPSA TSPAN4 USP40
GO Annotations	Cellular Component	Plasma Membrane Focal Adhesion Integrin Complex Cell Surface Membrane Integrin Alpha6-beta1 Complex Integrin Alpha6-beta4 Complex
	Molecular Function	Protein Binding Insulin-like Growth Factor I Binding Signaling Receptor Activity Neuregulin Binding Cadherin Binding Metal Ion Binding
	Biological Process	Cell-substrate Junction Assembly Cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Ectodermal Cell Differentiation Positive Regulation Of Neuron Projection Development Positive Regulation Of Cell Migration Cell-substrate Adhesion Nail Development Positive Regulation Of Apoptotic Process Positive Regulation Of GTPase Activity Skin Morphogenesis Positive Regulation Of Transcription By RNA Polymerase II Leukocyte Migration Cell-cell Adhesion Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways	Assembly of collagen fibrils and other multimeric structures Basigin interactions Integrin cell surface interactions Integrin cell surface interactions Laminin interactions Laminin interactions Syndecan interactions Type I hemidesmosome assembly Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin Developmental Lineage of Mammary Gland Luminal Epithelial Cells Developmental Lineage of Mammary Gland Alveolar Cells Developmental Lineage of Mammary Gland Myoepithelial Cells Developmental Lineage of Mammary Stem Cells
Diseases	Epidermolysis bullosa, junctional, including: Epidermolysis bullosa, junctional, Herlitz type (JEB-H); Epidermolysis bullosa, junctional, non-Herlitz type (JEB-nH); Epidermolysis bullosa, junctional, with pyloric atresia (JEB-PA)
GWAS	Alzheimer's disease biomarkers ( 23419831 ) Diabetic kidney disease ( 26305897 ) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Food allergy ( 29030101 ) Metabolite levels ( 23823483 ) Peanut allergy ( 29030101 ) Prostate cancer ( 19767753 31562322 )
Entrez ID	3655
HPRD ID	00945
Ensembl ID	ENSG00000091409
Uniprot IDs	A0A8C8KBL6 A0AAQ5BID9 P23229
PDB IDs	7CEB 7CEC
GO Terms Enriched among Interactors ?	Cell Adhesion Integrin Binding Cell-substrate Adhesion Hemidesmosome Assembly Hemidesmosome Cell-matrix Adhesion Extracellular Exosome Focal Adhesion Cell Migration Endocytosis Positive Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Endocytosis Plasma Membrane Laminin Binding Membrane Cell Motility Positive Regulation Of Transport Regulation Of Superoxide Metabolic Process Cell Adhesion Mediated By Integrin Vesicle-mediated Transport Low-density Lipoprotein Particle Mediated Signaling Import Into Cell Cell Surface Cell-substrate Junction Assembly Cell-substrate Junction Organization Regulation Of Spontaneous Synaptic Transmission Presynaptic Endocytosis Regulation Of Reactive Oxygen Species Metabolic Process Cell-cell Adhesion Mediated By Integrin Regulation Of Endocytosis Regulation Of Action Potential Cellular Response To Hydroperoxide Positive Regulation Of Cellular Component Organization Positive Regulation Of Supramolecular Fiber Organization Leukocyte Activation Receptor-mediated Endocytosis Vesicle Regulation Of Transport Receptor Internalization Receptor Complex Regulation Of Supramolecular Fiber Organization Insulin Receptor Substrate Binding Cell-cell Junction Response To Manganese Ion Anchoring Junction Cell Activation Mesodermal Cell Differentiation Endothelial Cell Migration Positive Regulation Of Membrane Protein Ectodomain Proteolysis Regulation Of Biological Quality