Alzheimer - Wiki-Pi

Symbols	Name 1	Name 2	Pathways 1 Hide	Pathways 2 Hide	Drugs 1 Hide
PSEN1 and EFHD1	presenilin 1	EF-hand domain family, member D1	Degradation of the extracellular matrix
PSEN1 and AP1M2	presenilin 1	adaptor-related protein complex 1, mu 2 subunit	Degradation of the extracellular matrix	Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters HIV Infection Host Interactions of HIV factors Golgi Associated Vesicle Biogenesis The role of Nef in HIV-1 replication and disease pathogenesis Nef mediated downregulation of MHC class I complex cell surface expression Clathrin derived vesicle budding Lysosome Vesicle Biogenesis MHC class II antigen presentation trans-Golgi Network Vesicle Budding Adaptive Immune System
PSEN1 and STAMBPL1	presenilin 1	STAM binding protein-like 1	Degradation of the extracellular matrix
PSEN1 and ECSIT	presenilin 1	ECSIT signalling integrator	Degradation of the extracellular matrix
PSEN1 and EPB41L3	presenilin 1	erythrocyte membrane protein band 4.1-like 3	Degradation of the extracellular matrix
PSEN1 and KCNIP3	presenilin 1	Kv channel interacting protein 3, calsenilin	Degradation of the extracellular matrix
PSEN1 and KANK2	presenilin 1	KN motif and ankyrin repeat domains 2	Degradation of the extracellular matrix
PSEN1 and RAB3A	presenilin 1	RAB3A, member RAS oncogene family	Degradation of the extracellular matrix	Dopamine Neurotransmitter Release Cycle Neurotransmitter Release Cycle Acetylcholine Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle Serotonin Neurotransmitter Release Cycle GABA synthesis, release, reuptake and degradation Glutamate Neurotransmitter Release Cycle Transmission across Chemical Synapses
PSEN1 and YME1L1	presenilin 1	YME1-like 1 ATPase	Degradation of the extracellular matrix
PSEN1 and MTCH1	presenilin 1	mitochondrial carrier 1	Degradation of the extracellular matrix
PSEN1 and HERPUD1	presenilin 1	homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1	Degradation of the extracellular matrix	ATF4 activates genes PERK regulates gene expression Unfolded Protein Response (UPR)
PSEN1 and ST13	presenilin 1	suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)	Degradation of the extracellular matrix
PSEN1 and PDCD4	presenilin 1	programmed cell death 4 (neoplastic transformation inhibitor)	Degradation of the extracellular matrix
PSEN1 and RAD23A	presenilin 1	RAD23 homolog A (S. cerevisiae)	Degradation of the extracellular matrix
PSEN1 and METTL2B	presenilin 1	methyltransferase like 2B	Degradation of the extracellular matrix
PSEN1 and RHEB	presenilin 1	Ras homolog enriched in brain	Degradation of the extracellular matrix	Insulin receptor signalling cascade IRS-mediated signalling Regulation of Rheb GTPase activity by AMPK mTOR signalling S6K1-mediated signalling IRS-related events mTOR signalling Release of eIF4E mTORC1-mediated signalling IGF1R signaling cascade S6K1-mediated signalling mTORC1-mediated signalling IRS-related events triggered by IGF1R IRS-mediated signalling Release of eIF4E Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) Energy dependent regulation of mTOR by LKB1-AMPK PKB-mediated events PI3K Cascade PKB-mediated events PI3K Cascade Signaling by Insulin receptor
PSEN1 and DLL1	presenilin 1	delta-like 1 (Drosophila)	Degradation of the extracellular matrix	Signaling by NOTCH4 Signaling by NOTCH1 HD Domain Mutants in Cancer Constitutive Signaling by NOTCH1 HD Domain Mutants Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Signaling by NOTCH NOTCH2 Activation and Transmission of Signal to the Nucleus Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Activated NOTCH1 Transmits Signal to the Nucleus Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Signaling by NOTCH2 Signaling by NOTCH1 Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by NOTCH1 in Cancer Signaling by NOTCH3 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Constitutive Signaling by NOTCH1 PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer
PSEN1 and FBXW7	presenilin 1	F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase	Degradation of the extracellular matrix	Protein folding Antigen processing: Ubiquitination & Proteasome degradation Chaperonin-mediated protein folding Association of TriC/CCT with target proteins during biosynthesis Class I MHC mediated antigen processing & presentation Adaptive Immune System
SCNN1B and HECW1	sodium channel, non voltage gated 1 beta subunit	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1	Ion channel transport Stimuli-sensing channels	misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN degradation of DVL Signaling by Wnt Signaling by WNT in cancer	Triamterene Amiloride
ETV4 and STK11	ets variant 4	serine/threonine kinase 11		Insulin receptor signalling cascade Integration of energy metabolism IRS-mediated signalling Regulation of AMPK activity via LKB1 mTOR signalling IRS-related events mTOR signalling IGF1R signaling cascade IRS-related events triggered by IGF1R IRS-mediated signalling Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) Energy dependent regulation of mTOR by LKB1-AMPK AMPK inhibits chREBP transcriptional activation activity PKB-mediated events PI3K Cascade PKB-mediated events PI3K Cascade Signaling by Insulin receptor

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