NOTCH1 and PSEN2 |
notch 1 |
presenilin 2 |
- Signaling by NOTCH1 HD Domain Mutants in Cancer
- Constitutive Signaling by NOTCH1 HD Domain Mutants
- Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
- Pre-NOTCH Processing in the Endoplasmic Reticulum
- Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
- Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
- Regulation of beta-cell development
- Generic Transcription Pathway
- Pre-NOTCH Transcription and Translation
- Signaling by NOTCH1
- Pre-NOTCH Expression and Processing
- Signaling by NOTCH1 in Cancer
- Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
- Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling
- FBXW7 Mutants and NOTCH1 in Cancer
- Pre-NOTCH Processing in Golgi
- Signaling by NOTCH
- Notch-HLH transcription pathway
- Activated NOTCH1 Transmits Signal to the Nucleus
- NOTCH1 Intracellular Domain Regulates Transcription
- Signaling by NOTCH1 PEST Domain Mutants in Cancer
- Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells
- Constitutive Signaling by NOTCH1 PEST Domain Mutants
|
- Signaling by NOTCH1 HD Domain Mutants in Cancer
- Axon guidance
- Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
- Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
- Signaling by NOTCH2
- EPH-ephrin mediated repulsion of cells
- Signaling by NOTCH1
- EPH-Ephrin signaling
- Signaling by NOTCH1 in Cancer
- Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
- FBXW7 Mutants and NOTCH1 in Cancer
- Signaling by NOTCH4
- Regulated proteolysis of p75NTR
- Signalling by NGF
- Cell death signalling via NRAGE, NRIF and NADE
- Signaling by NOTCH
- p75 NTR receptor-mediated signalling
- Signaling by ERBB4
- NOTCH2 Activation and Transmission of Signal to the Nucleus
- Activated NOTCH1 Transmits Signal to the Nucleus
- Nuclear signaling by ERBB4
- NRIF signals cell death from the nucleus
- Signaling by NOTCH1 PEST Domain Mutants in Cancer
- Signaling by NOTCH3
- Constitutive Signaling by NOTCH1 PEST Domain Mutants
|
|
|
|
|
PAX2 and WT1 |
paired box 2 |
Wilms tumor 1 |
|
|
|
|
|
|
SNCA and CYCS |
synuclein, alpha (non A4 component of amyloid precursor) |
cytochrome c, somatic |
|
- Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
- Organelle biogenesis and maintenance
- Detoxification of Reactive Oxygen Species
- Respiratory electron transport
- Cytochrome c-mediated apoptotic response
- Mitochondrial biogenesis
- Activation of caspases through apoptosome-mediated cleavage
- Formation of apoptosome
- Release of apoptotic factors from the mitochondria
- Apoptotic factor-mediated response
- Programmed Cell Death
- Transcriptional activation of mitochondrial biogenesis
- The citric acid (TCA) cycle and respiratory electron transport
- Orphan transporters
- Intrinsic Pathway for Apoptosis
|
|
- Minocycline
- Protoporphyrin Ix Containing Co
- Heme
- Heme C
- Protoporphyrin Ix Containing Zn
- N-Trimethyllysine
- Zinc Substituted Heme C
|
|
|
ABL1 and PIK3R1 |
ABL proto-oncogene 1, non-receptor tyrosine kinase |
phosphoinositide-3-kinase, regulatory subunit 1 (alpha) |
- Role of Abl in Robo-Slit signaling
- CDO in myogenesis
- Axon guidance
- Myogenesis
- Fcgamma receptor (FCGR) dependent phagocytosis
- Factors involved in megakaryocyte development and platelet production
- Signaling by Robo receptor
- Regulation of actin dynamics for phagocytic cup formation
- Innate Immune System
|
- Signaling by the B Cell Receptor (BCR)
- Signaling by GPCR
- Metabolism of lipids and lipoproteins
- Signaling by FGFR in disease
- Signaling by EGFRvIII in Cancer
- Signaling by SCF-KIT
- Downstream signaling events of B Cell Receptor (BCR)
- DAP12 signaling
- PI3K/AKT activation
- Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
- Interleukin receptor SHC signaling
- PI-3K cascade
- Gastrin-CREB signalling pathway via PKC and MAPK
- Signaling by FGFR1 mutants
- Interleukin-7 signaling
- Role of phospholipids in phagocytosis
- Phospholipid metabolism
- Fcgamma receptor (FCGR) dependent phagocytosis
- PI3K Cascade
- Signaling by PDGF
- DAP12 interactions
- GAB1 signalosome
- G-protein beta:gamma signalling
- CD28 co-stimulation
- CD28 dependent PI3K/Akt signaling
- Signaling by ERBB4
- Constitutive PI3K/AKT Signaling in Cancer
- Role of LAT2/NTAL/LAB on calcium mobilization
- PI3K events in ERBB4 signaling
- G alpha (q) signalling events
- Signaling by ERBB2
- Signaling by EGFR
- GPCR downstream signaling
- Signaling by Interleukins
- TCR signaling
- Signaling by VEGF
- GP1b-IX-V activation signalling
- Downstream signal transduction
- Signaling by FGFR mutants
- Fc epsilon receptor (FCERI) signaling
- Signaling by EGFR in Cancer
- Nephrin interactions
- Interleukin-2 signaling
- PI3K/AKT Signaling in Cancer
- Platelet activation, signaling and aggregation
- Interleukin-3, 5 and GM-CSF signaling
- Adaptive Immune System
- G alpha (q) signalling events
- Downstream TCR signaling
- Costimulation by the CD28 family
- IRS-mediated signalling
- PIP3 activates AKT signaling
- IGF1R signaling cascade
- VEGFA-VEGFR2 Pathway
- Synthesis of PIPs at the plasma membrane
- IRS-related events triggered by IGF1R
- G beta:gamma signalling through PI3Kgamma
- PI3K events in ERBB2 signaling
- Regulation of signaling by CBL
- Downstream signaling of activated FGFR
- G alpha (12/13) signalling events
- Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
- PI Metabolism
- Innate Immune System
- Signaling by Insulin receptor
- Signalling by NGF
- Insulin receptor signalling cascade
- Cytokine Signaling in Immune system
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- IRS-related events
- NGF signalling via TRKA from the plasma membrane
- Tie2 Signaling
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- Cell surface interactions at the vascular wall
- Signaling by FGFR
- IRS-mediated signalling
- Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
- GPVI-mediated activation cascade
- Interleukin receptor SHC signaling
- Signaling by FGFR1 fusion mutants
- Constitutive Signaling by EGFRvIII
- PI3K Cascade
|
- Adenosine triphosphate
- Imatinib
- Dasatinib
- N-[4-Methyl-3-[[4-(3-Pyridinyl)-2-Pyrimidinyl]Amino]Phenyl]-3-Pyridinecarboxamide
- Nilotinib
- Bosutinib
- 2-{[(6-OXO-1,6-DIHYDROPYRIDIN-3-YL)METHYL]AMINO}-N-[4-PROPYL-3-(TRIFLUOROMETHYL)PHENYL]BENZAMIDE
- 1-[4-(PYRIDIN-4-YLOXY)PHENYL]-3-[3-(TRIFLUOROMETHYL)PHENYL]UREA
- MYRISTIC ACID
- 6-(2,6-DICHLOROPHENYL)-2-{[3-(HYDROXYMETHYL)PHENYL]AMINO}-8-METHYLPYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE
- 5-[3-(2-METHOXYPHENYL)-1H-PYRROLO[2,3-B]PYRIDIN-5-YL]-N,N-DIMETHYLPYRIDINE-3-CARBOXAMIDE
- 2-amino-5-[3-(1-ethyl-1H-pyrazol-5-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl]-N,N-dimethylbenzamide
- Regorafenib
- Ponatinib
|
- Isoproterenol
- (1S,6BR,9AS,11R,11BR)-9A,11B-DIMETHYL-1-[(METHYLOXY)METHYL]-3,6,9-TRIOXO-1,6,6B,7,8,9,9A,10,11,11B-DECAHYDRO-3H-FURO[4,3,2-DE]INDENO[4,5-H][2]BENZOPYRAN-11-YL ACETATE
|
|
|
ABL1 and CDON |
ABL proto-oncogene 1, non-receptor tyrosine kinase |
cell adhesion associated, oncogene regulated |
- Role of Abl in Robo-Slit signaling
- CDO in myogenesis
- Axon guidance
- Myogenesis
- Fcgamma receptor (FCGR) dependent phagocytosis
- Factors involved in megakaryocyte development and platelet production
- Signaling by Robo receptor
- Regulation of actin dynamics for phagocytic cup formation
- Innate Immune System
|
- CDO in myogenesis
- Myogenesis
- Hedgehog 'on' state
- Signaling by Hedgehog
- Ligand-receptor interactions
|
- Adenosine triphosphate
- Imatinib
- Dasatinib
- N-[4-Methyl-3-[[4-(3-Pyridinyl)-2-Pyrimidinyl]Amino]Phenyl]-3-Pyridinecarboxamide
- Nilotinib
- Bosutinib
- 2-{[(6-OXO-1,6-DIHYDROPYRIDIN-3-YL)METHYL]AMINO}-N-[4-PROPYL-3-(TRIFLUOROMETHYL)PHENYL]BENZAMIDE
- 1-[4-(PYRIDIN-4-YLOXY)PHENYL]-3-[3-(TRIFLUOROMETHYL)PHENYL]UREA
- MYRISTIC ACID
- 6-(2,6-DICHLOROPHENYL)-2-{[3-(HYDROXYMETHYL)PHENYL]AMINO}-8-METHYLPYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE
- 5-[3-(2-METHOXYPHENYL)-1H-PYRROLO[2,3-B]PYRIDIN-5-YL]-N,N-DIMETHYLPYRIDINE-3-CARBOXAMIDE
- 2-amino-5-[3-(1-ethyl-1H-pyrazol-5-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl]-N,N-dimethylbenzamide
- Regorafenib
- Ponatinib
|
|
|
|
ACAN and MMP3 |
aggrecan |
matrix metallopeptidase 3 (stromelysin 1, progelatinase) |
|
- Signaling by GPCR
- EGFR Transactivation by Gastrin
- Collagen formation
- Collagen degradation
- Gastrin-CREB signalling pathway via PKC and MAPK
- Activation of Matrix Metalloproteinases
- Degradation of the extracellular matrix
- Assembly of collagen fibrils and other multimeric structures
|
|
- Marimastat
- N-Hydroxy 1n(4-Methoxyphenyl)Sulfonyl-4-(Z,E-N-Methoxyimino)Pyrrolidine-2r-Carboxamide
- 3-Methylpyridine
- A Disubstituted Succinyl Caprolactam Hydroxymate Mmp3inhibitor
- N-Hydroxy-4-[(4-Methoxylphenyl)Sulfonyl]-2,2-Dimethyl-Hexahydro-1,4-Thiazepine-3(S)-Carboxamide
- (1n)-4-N-Butoxyphenylsulfonyl-(2r)-N-Hydroxycarboxamido-(4s)-Methanesulfonylamino-Pyrrolidine
- 3-(1h-Indol-3-Yl)-2-[4-(4-Phenyl-Piperidin-1-Yl)-Benzenesulfonylamino]-Propionic Acid
- Hydroxyaminovaline
- 1-Methyloxy-4-Sulfone-Benzene
- 5-Methyl-5-(4-Phenoxy-Phenyl)-Pyrimidine-2,4,6-Trione
- 1-Benzyl-3-(4-Methoxy-Benzenesulfonyl)-6-Oxo-Hexahydro-Pyrimidine-4-Carboxylic Acid Hydroxyamide
- N-Hydroxy-1-(4-Methoxyphenyl)Sulfonyl-4-Benzyloxycarbonyl-Piperazine-2-Carboxamide
- R-2-{[4\'-Methoxy-(1,1\'-Biphenyl)-4-Yl]-Sulfonyl}-Amino-6-Methoxy-Hex-4-Ynoic Acid
- 2-[3-(5-MERCAPTO-[1,3,4]THIADIAZOL-2-YL)-UREIDO]-N-METHYL-3-PHENYL-PROPIONAMIDE
- [4-(4-PHENYL-PIPERIDIN-1-YL)-BENZENESULFONYLAMINO]-ACETIC ACID
- [2-(5-MERCAPTO-[1,3,4]THIADIAZOL-2-YLCARBAMOYL)-1-PHENYL-ETHYL]-CARBAMIC ACID BENZYL ESTER
- 2-[3-(5-MERCAPTO-[1,3,4]THIADIAZOL-2YL)-UREIDO]-N-METHYL-3-PENTAFLUOROPHENYL-PROPIONAMIDE
- N~2~-(biphenyl-4-ylsulfonyl)-N-hydroxy-N~2~-(2-hydroxyethyl)glycinamide
- 3-[(4\'-cyanobiphenyl-4-yl)oxy]-N-hydroxypropanamide
- N-ISOBUTYL-N-[4-METHOXYPHENYLSULFONYL]GLYCYL HYDROXAMIC ACID
- N-[[2-METHYL-4-HYDROXYCARBAMOYL]BUT-4-YL-N]-BENZYL-P-[PHENYL]-P-[METHYL]PHOSPHINAMID
- 2-(2-{2-[(BIPHENYL-4-YLMETHYL)-AMINO]-3-MERCAPTO-PENTANOYLAMINO}-ACETYLAMINO)-3-METHYL-BUTYRIC ACID METHYL ESTER
|
|
|
APOA1 and APOC1 |
apolipoprotein A-I |
apolipoprotein C-I |
- Lipoprotein metabolism
- PPARA activates gene expression
- Metabolism of lipids and lipoproteins
- ABC-family proteins mediated transport
- Chylomicron-mediated lipid transport
- Platelet degranulation
- Amyloids
- Response to elevated platelet cytosolic Ca2+
- Scavenging by Class A Receptors
- Retinoid metabolism and transport
- Fatty acid, triacylglycerol, and ketone body metabolism
- Lipid digestion, mobilization, and transport
- Diseases associated with visual transduction
- HDL-mediated lipid transport
- Scavenging of heme from plasma
- Visual phototransduction
- Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
- Platelet activation, signaling and aggregation
- Scavenging by Class B Receptors
- ABCA transporters in lipid homeostasis
|
|
|
|
|
|
ATR and POLN |
ATR serine/threonine kinase |
polymerase (DNA directed) nu |
- Fanconi Anemia pathway
- G2/M DNA damage checkpoint
- G2/M Checkpoints
- Meiotic synapsis
- Regulation of HSF1-mediated heat shock response
- Cellular response to heat stress
- Regulation of the Fanconi anemia pathway
- Activation of ATR in response to replication stress
- Cell Cycle Checkpoints
|
|
|
|
|
|
BMPR1B and RRAS2 |
bone morphogenetic protein receptor, type IB |
related RAS viral (r-ras) oncogene homolog 2 |
|
|
|
|
|
|
BRCA1 and PIK3R1 |
breast cancer 1, early onset |
phosphoinositide-3-kinase, regulatory subunit 1 (alpha) |
- ATM mediated phosphorylation of repair proteins
- Meiotic recombination
- Fanconi Anemia pathway
- ATM mediated response to DNA double-strand break
- Homologous Recombination Repair
- Meiotic synapsis
- Homologous recombination repair of replication-independent double-strand breaks
- Recruitment of repair and signaling proteins to double-strand breaks
- Double-Strand Break Repair
|
- Signaling by the B Cell Receptor (BCR)
- Signaling by GPCR
- Metabolism of lipids and lipoproteins
- Signaling by FGFR in disease
- Signaling by EGFRvIII in Cancer
- Signaling by SCF-KIT
- Downstream signaling events of B Cell Receptor (BCR)
- DAP12 signaling
- PI3K/AKT activation
- Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
- Interleukin receptor SHC signaling
- PI-3K cascade
- Gastrin-CREB signalling pathway via PKC and MAPK
- Signaling by FGFR1 mutants
- Interleukin-7 signaling
- Role of phospholipids in phagocytosis
- Phospholipid metabolism
- Fcgamma receptor (FCGR) dependent phagocytosis
- PI3K Cascade
- Signaling by PDGF
- DAP12 interactions
- GAB1 signalosome
- G-protein beta:gamma signalling
- CD28 co-stimulation
- CD28 dependent PI3K/Akt signaling
- Signaling by ERBB4
- Constitutive PI3K/AKT Signaling in Cancer
- Role of LAT2/NTAL/LAB on calcium mobilization
- PI3K events in ERBB4 signaling
- G alpha (q) signalling events
- Signaling by ERBB2
- Signaling by EGFR
- GPCR downstream signaling
- Signaling by Interleukins
- TCR signaling
- Signaling by VEGF
- GP1b-IX-V activation signalling
- Downstream signal transduction
- Signaling by FGFR mutants
- Fc epsilon receptor (FCERI) signaling
- Signaling by EGFR in Cancer
- Nephrin interactions
- Interleukin-2 signaling
- PI3K/AKT Signaling in Cancer
- Platelet activation, signaling and aggregation
- Interleukin-3, 5 and GM-CSF signaling
- Adaptive Immune System
- G alpha (q) signalling events
- Downstream TCR signaling
- Costimulation by the CD28 family
- IRS-mediated signalling
- PIP3 activates AKT signaling
- IGF1R signaling cascade
- VEGFA-VEGFR2 Pathway
- Synthesis of PIPs at the plasma membrane
- IRS-related events triggered by IGF1R
- G beta:gamma signalling through PI3Kgamma
- PI3K events in ERBB2 signaling
- Regulation of signaling by CBL
- Downstream signaling of activated FGFR
- G alpha (12/13) signalling events
- Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
- PI Metabolism
- Innate Immune System
- Signaling by Insulin receptor
- Signalling by NGF
- Insulin receptor signalling cascade
- Cytokine Signaling in Immune system
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- IRS-related events
- NGF signalling via TRKA from the plasma membrane
- Tie2 Signaling
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- Cell surface interactions at the vascular wall
- Signaling by FGFR
- IRS-mediated signalling
- Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
- GPVI-mediated activation cascade
- Interleukin receptor SHC signaling
- Signaling by FGFR1 fusion mutants
- Constitutive Signaling by EGFRvIII
- PI3K Cascade
|
|
- Isoproterenol
- (1S,6BR,9AS,11R,11BR)-9A,11B-DIMETHYL-1-[(METHYLOXY)METHYL]-3,6,9-TRIOXO-1,6,6B,7,8,9,9A,10,11,11B-DECAHYDRO-3H-FURO[4,3,2-DE]INDENO[4,5-H][2]BENZOPYRAN-11-YL ACETATE
|
|
|
C3 and CR1 |
complement component 3 |
complement component (3b/4b) receptor 1 (Knops blood group) |
- Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)
- Signaling by GPCR
- Alternative complement activation
- Class A/1 (Rhodopsin-like receptors)
- Activation of C3 and C5
- Metabolic disorders of biological oxidation enzymes
- GPCR ligand binding
- Initial triggering of complement
- GPCR downstream signaling
- Peptide ligand-binding receptors
- Regulation of Complement cascade
- Complement cascade
- G alpha (i) signalling events
- Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
- Adaptive Immune System
- Innate Immune System
|
- Regulation of Complement cascade
- Complement cascade
- Innate Immune System
|
|
|
|
|
C4A and CR1 |
complement component 4A (Rodgers blood group) |
complement component (3b/4b) receptor 1 (Knops blood group) |
- Regulation of Complement cascade
- Complement cascade
- Activation of C3 and C5
- Initial triggering of complement
- Innate Immune System
|
- Regulation of Complement cascade
- Complement cascade
- Innate Immune System
|
|
|
|
|
CA2 and SLC4A8 |
carbonic anhydrase II |
solute carrier family 4, sodium bicarbonate cotransporter, member 8 |
- O2/CO2 exchange in erythrocytes
- Erythrocytes take up carbon dioxide and release oxygen
- Erythrocytes take up oxygen and release carbon dioxide
- Reversible hydration of carbon dioxide
|
- Transport of inorganic cations/anions and amino acids/oligopeptides
- SLC-mediated transmembrane transport
- Bicarbonate transporters
|
- Methyclothiazide
- Topiramate
- Ethoxzolamide
- Bendroflumethiazide
- Benzthiazide
- Cyclothiazide
- Furosemide
- Methazolamide
- Hydroflumethiazide
- Acetazolamide
- Dorzolamide
- Chlorothiazide
- Zonisamide
- Hydrochlorothiazide
- Trichlormethiazide
- Ethinamate
- Diazoxide
- Dichlorphenamide
- Brinzolamide
- Quinethazone
- 4-(Hydroxymercury)Benzoic Acid
- N-Benzyl-4-Sulfamoyl-Benzamide
- 4-Flourobenzenesulfonamide
- Formic Acid
- AL5424
- N-(2-Flouro-Benzyl)-4-Sulfamoyl-Benzamide
- 3,5-Difluorobenzenesulfonamide
- Al7089a
- 4-(Aminosulfonyl)-N-[(2,4,6-Trifluorophenyl)Methyl]-Benzamide
- 6-Oxo-8,9,10,11-Tetrahydro-7h-Cyclohepta[C][1]Benzopyran-3-O-Sulfamate
- 4-(Aminosulfonyl)-N-[(4-Fluorophenyl)Methyl]-Benzamide
- (R)-N-(3-Indol-1-Yl-2-Methyl-Propyl)-4-Sulfamoyl-Benzamide
- Aminodi(Ethyloxy)Ethylaminocarbonylbenzenesulfonamide
- AL7182
- N-(2,3,4,5,6-Pentaflouro-Benzyl)-4-Sulfamoyl-Benzamide
- Cyanamide
- 4-(Aminosulfonyl)-N-[(3,4,5-Trifluorophenyl)Methyl]-Benzamide
- Dansylamide
- Sulfamic Acid 2,3-O-(1-Methylethylidene)-4,5-O-Sulfonyl-Beta-Fructopyranose Ester
- N-(2-Thienylmethyl)-2,5-Thiophenedisulfonamide
- 4-(Aminosulfonyl)-N-[(2,5-Difluorophenyl)Methyl]-Benzamide
- AL7099A
- Al-6619, [2h-Thieno[3,2-E]-1,2-Thiazine-6-Sulfonamide,2-(3-Hydroxyphenyl)-3-(4-Morpholinyl)-, 1,1-Dioxide]
- 2,6-Difluorobenzenesulfonamide
- 1-Methyl-3-Oxo-1,3-Dihydro-Benzo[C]Isothiazole-5-Sulfonic Acid Amide
- (4-sulfamoyl-phenyl)-thiocarbamic acid O-(2-thiophen-3-yl-ethyl) ester
- 4-Methylimidazole
- AL5927
- 1,2,4-Triazole
- N-[2-(1h-Indol-5-Yl)-Butyl]-4-Sulfamoyl-Benzamide
- Al-6629, [2h-Thieno[3,2-E]-1,2-Thiazine-6-Sulfonamide,2-(3-Methoxyphenyl)-3-(4-Morpholinyl)-, 1,1-Dioxide]
- Methyl Mercury Ion
- 4-Sulfonamide-[1-(4-Aminobutane)]Benzamide
- N-(2,6-Diflouro-Benzyl)-4-Sulfamoyl-Benzamide
- AL4623
- Urea
- (S)-N-(3-Indol-1-Yl-2-Methyl-Propyl)-4-Sulfamoyl-Benzamide
- Mercuribenzoic Acid
- 4-Sulfonamide-[4-(Thiomethylaminobutane)]Benzamide
- (4s-Trans)-4-(Methylamino)-5,6-Dihydro-6-Methyl-4h-Thieno(2,3-B)Thiopyran-2-Sulfonamide-7,7-Dioxide
- AL5300
- 4-(Aminosulfonyl)-N-[(2,4-Difluorophenyl)Methyl]-Benzamide
- 3-Mercuri-4-Aminobenzenesulfonamide
- AL6528
- 3-Nitro-4-(2-Oxo-Pyrrolidin-1-Yl)-Benzenesulfonamide
- 4-(Aminosulfonyl)-N-[(2,3,4-Trifluorophenyl)Methyl]-Benzamide
- 4-[(3-BROMO-4-O-SULFAMOYLBENZYL)(4-CYANOPHENYL)AMINO]-4H-[1,2,4]-TRIAZOLE
- 4-[(4-O-SULFAMOYLBENZYL)(4-CYANOPHENYL)AMINO]-4H-[1,2,4]-TRIAZOLE
- 1-N-(4-SULFAMOYLPHENYL-ETHYL)-2,4,6-TRIMETHYLPYRIDINIUM
- 5-{[(4-AMINO-3-CHLORO-5-FLUOROPHENYL)SULFONYL]AMINO}-1,3,4-THIADIAZOLE-2-SULFONAMIDE
- 2-(cycloheptylmethyl)-1,1-dioxido-1-benzothiophen-6-yl sulfamate
- N-[(2R)-5-(aminosulfonyl)-2,3-dihydro-1H-inden-2-yl]-2-propylpentanamide
- 5-[(phenylsulfonyl)amino]-1,3,4-thiadiazole-2-sulfonamide
- THIOPHENE-2,5-DISULFONIC ACID 2-AMIDE-5-(4-METHYL-BENZYLAMIDE)
- 4-chloro-N-[(2S)-2-methyl-2,3-dihydro-1H-indol-1-yl]-3-sulfamoylbenzamide
- N-[4-(AMINOSULFONYL)PHENYL]-2-MERCAPTOBENZAMIDE
- (17beta)-17-(cyanomethyl)-2-methoxyestra-1(10),2,4-trien-3-yl sulfamate
- 5-(2-chlorophenyl)-1,3,4-thiadiazole-2-sulfonamide
- PHENYLALANYLAMINODI(ETHYLOXY)ETHYL BENZENESULFONAMIDEAMINOCARBONYLBENZENESULFONAMIDE
- N-(2,3-DIFLUORO-BENZYL)-4-SULFAMOYL-BENZAMIDE
- 2-chloro-5-[(1S)-1-hydroxy-3-oxo-2H-isoindol-1-yl]benzenesulfonamide
- 2-(1,3-thiazol-4-yl)-1H-benzimidazole-5-sulfonamide
- N-{2-[4-(AMINOSULFONYL)PHENYL]ETHYL}ACETAMIDE
- 3-[4-(AMINOSULFONYL)PHENYL]PROPANOIC ACID
- ETHYL 3-[4-(AMINOSULFONYL)PHENYL]PROPANOATE
- indane-5-sulfonamide
- 4-({[(4-METHYLPIPERAZIN-1-YL)AMINO]CARBONOTHIOYL}AMINO)BENZENESULFONAMIDE
- N-({[4-(AMINOSULFONYL)PHENYL]AMINO}CARBONYL)-4-METHYLBENZENESULFONAMIDE
- SULTHIAME
- (9BETA,13ALPHA,14BETA,17ALPHA)-2-METHOXYESTRA-1,3,5(10)-TRIENE-3,17-DIYL DISULFAMATE
- (4aS,4bR,10bS,12aS)-12a-methyl-1,3-dioxo-2-(pyridin-3-ylmethyl)-1,2,3,4,4a,4b,5,6,10b,11,12,12a-dodecahydronaphtho[2,1-f]isoquinolin-8-yl sulfamate
- 6-CHLORO-3-(DICHLOROMETHYL)-3,4-DIHYDRO-2H-1,2,4-BENZOTHIADIAZINE-7-SULFONAMIDE 1,1-DIOXIDE
- 2-(hydrazinocarbonyl)-3-phenyl-1H-indole-5-sulfonamide
- 6-HYDROXY-1,3-BENZOTHIAZOLE-2-SULFONAMIDE
- 4-(2-AMINOETHYL)BENZENESULFONAMIDE
- Ellagic Acid
|
|
|
|
CAMK4 and NOTCH1 |
calcium/calmodulin-dependent protein kinase IV |
notch 1 |
- Signaling by GPCR
- Ca-dependent events
- CaM pathway
- Organelle biogenesis and maintenance
- Signaling by FGFR in disease
- Phospholipase C-mediated cascade
- Signaling by EGFRvIII in Cancer
- PLCG1 events in ERBB2 signaling
- DAG and IP3 signaling
- CaM pathway
- DAP12 signaling
- Downstream signaling of activated FGFR
- Activation of NMDA receptor upon glutamate binding and postsynaptic events
- Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
- Post NMDA receptor activation events
- Innate Immune System
- Signaling by PDGF
- Calmodulin induced events
- Signalling by NGF
- CaMK IV-mediated phosphorylation of CREB
- DAP12 interactions
- PLC beta mediated events
- Opioid Signalling
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- NGF signalling via TRKA from the plasma membrane
- G-protein mediated events
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- Signaling by FGFR
- EGFR interacts with phospholipase C-gamma
- Mitochondrial biogenesis
- Signaling by ERBB2
- CaMK IV-mediated phosphorylation of CREB
- Signaling by EGFR
- Activation of CaMK IV
- CREB phosphorylation through the activation of CaMKK
- Downstream signal transduction
- Calmodulin induced events
- PLC-gamma1 signalling
- Signaling by EGFR in Cancer
- Transcriptional activation of mitochondrial biogenesis
- Transmission across Chemical Synapses
|
- Signaling by NOTCH1 HD Domain Mutants in Cancer
- Constitutive Signaling by NOTCH1 HD Domain Mutants
- Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
- Pre-NOTCH Processing in the Endoplasmic Reticulum
- Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
- Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
- Regulation of beta-cell development
- Generic Transcription Pathway
- Pre-NOTCH Transcription and Translation
- Signaling by NOTCH1
- Pre-NOTCH Expression and Processing
- Signaling by NOTCH1 in Cancer
- Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
- Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling
- FBXW7 Mutants and NOTCH1 in Cancer
- Pre-NOTCH Processing in Golgi
- Signaling by NOTCH
- Notch-HLH transcription pathway
- Activated NOTCH1 Transmits Signal to the Nucleus
- NOTCH1 Intracellular Domain Regulates Transcription
- Signaling by NOTCH1 PEST Domain Mutants in Cancer
- Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells
- Constitutive Signaling by NOTCH1 PEST Domain Mutants
|
|
|
|
|
CD33 and PTPN11 |
CD33 molecule |
protein tyrosine phosphatase, non-receptor type 11 |
|
- Signaling by FGFR in disease
- Netrin mediated repulsion signals
- Signaling by EGFRvIII in Cancer
- Interferon gamma signaling
- Downstream signaling events of B Cell Receptor (BCR)
- Toll Like Receptor TLR1:TLR2 Cascade
- PI3K/AKT activation
- Toll Like Receptor 5 (TLR5) Cascade
- Gastrin-CREB signalling pathway via PKC and MAPK
- MyD88 dependent cascade initiated on endosome
- SOS-mediated signalling
- Prolactin receptor signaling
- SHC-mediated signalling
- PI3K Cascade
- TRIF-mediated TLR3/TLR4 signaling
- ERK1 activation
- ERK1 activation
- Spry regulation of FGF signaling
- Constitutive PI3K/AKT Signaling in Cancer
- Platelet sensitization by LDL
- Signaling by VEGF
- Signalling to RAS
- Toll Like Receptor 3 (TLR3) Cascade
- Downstream signal transduction
- Interleukin-2 signaling
- PI3K/AKT Signaling in Cancer
- Frs2-mediated activation
- Adaptive Immune System
- Axon guidance
- IRS-mediated signalling
- Interleukin-6 signaling
- VEGFA-VEGFR2 Pathway
- Activated TLR4 signalling
- GRB2 events in ERBB2 signaling
- VEGFR2 mediated cell proliferation
- PI3K events in ERBB2 signaling
- MyD88:Mal cascade initiated on plasma membrane
- TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
- NCAM signaling for neurite out-growth
- Netrin-1 signaling
- RAF/MAP kinase cascade
- Signalling to p38 via RIT and RIN
- Innate Immune System
- Signaling by Insulin receptor
- Insulin receptor signalling cascade
- Interferon Signaling
- CTLA4 inhibitory signaling
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- IRS-related events
- SHC-related events
- Tie2 Signaling
- PECAM1 interactions
- Signaling by FGFR
- ARMS-mediated activation
- Nuclear signaling by ERBB4
- Toll-Like Receptors Cascades
- Toll Like Receptor 10 (TLR10) Cascade
- Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
- PD-1 signaling
- PI3K Cascade
- Signaling by the B Cell Receptor (BCR)
- Signaling by GPCR
- FCERI mediated MAPK activation
- Signaling by SCF-KIT
- SHC1 events in ERBB2 signaling
- DAP12 signaling
- PI-3K cascade
- Toll Like Receptor 9 (TLR9) Cascade
- Negative regulation of FGFR signaling
- Signaling by PDGF
- DAP12 interactions
- Regulation of IFNA signaling
- GAB1 signalosome
- GRB2 events in EGFR signaling
- SHC-related events triggered by IGF1R
- Signal regulatory protein (SIRP) family interactions
- Signaling by ERBB4
- Role of LAT2/NTAL/LAB on calcium mobilization
- PI3K events in ERBB4 signaling
- Signaling by ERBB2
- Toll Like Receptor 2 (TLR2) Cascade
- Signaling by EGFR
- Signaling by Interleukins
- SHC1 events in ERBB4 signaling
- Platelet homeostasis
- Toll Like Receptor 4 (TLR4) Cascade
- Signaling by EGFR in Cancer
- Fc epsilon receptor (FCERI) signaling
- Interleukin-3, 5 and GM-CSF signaling
- Signaling by Leptin
- Signalling to ERKs
- Prolonged ERK activation events
- Costimulation by the CD28 family
- ERK activation
- PIP3 activates AKT signaling
- Toll Like Receptor 7/8 (TLR7/8) Cascade
- IGF1R signaling cascade
- Toll Like Receptor TLR6:TLR2 Cascade
- Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
- IRS-related events triggered by IGF1R
- MyD88 cascade initiated on plasma membrane
- ERK activation
- Downstream signaling of activated FGFR
- Interferon alpha/beta signaling
- Signalling by NGF
- SOS-mediated signalling
- MAP kinase activation in TLR cascade
- SHC-mediated signalling
- Cytokine Signaling in Immune system
- NGF signalling via TRKA from the plasma membrane
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- MyD88-independent cascade
- Cell surface interactions at the vascular wall
- ERK2 activation
- SHC1 events in EGFR signaling
- IRS-mediated signalling
- FRS2-mediated cascade
- ERK2 activation
- Regulation of IFNG signaling
|
|
|
|
|
CD40 and PIK3R1 |
CD40 molecule, TNF receptor superfamily member 5 |
phosphoinositide-3-kinase, regulatory subunit 1 (alpha) |
|
- Signaling by the B Cell Receptor (BCR)
- Signaling by GPCR
- Metabolism of lipids and lipoproteins
- Signaling by FGFR in disease
- Signaling by EGFRvIII in Cancer
- Signaling by SCF-KIT
- Downstream signaling events of B Cell Receptor (BCR)
- DAP12 signaling
- PI3K/AKT activation
- Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
- Interleukin receptor SHC signaling
- PI-3K cascade
- Gastrin-CREB signalling pathway via PKC and MAPK
- Signaling by FGFR1 mutants
- Interleukin-7 signaling
- Role of phospholipids in phagocytosis
- Phospholipid metabolism
- Fcgamma receptor (FCGR) dependent phagocytosis
- PI3K Cascade
- Signaling by PDGF
- DAP12 interactions
- GAB1 signalosome
- G-protein beta:gamma signalling
- CD28 co-stimulation
- CD28 dependent PI3K/Akt signaling
- Signaling by ERBB4
- Constitutive PI3K/AKT Signaling in Cancer
- Role of LAT2/NTAL/LAB on calcium mobilization
- PI3K events in ERBB4 signaling
- G alpha (q) signalling events
- Signaling by ERBB2
- Signaling by EGFR
- GPCR downstream signaling
- Signaling by Interleukins
- TCR signaling
- Signaling by VEGF
- GP1b-IX-V activation signalling
- Downstream signal transduction
- Signaling by FGFR mutants
- Fc epsilon receptor (FCERI) signaling
- Signaling by EGFR in Cancer
- Nephrin interactions
- Interleukin-2 signaling
- PI3K/AKT Signaling in Cancer
- Platelet activation, signaling and aggregation
- Interleukin-3, 5 and GM-CSF signaling
- Adaptive Immune System
- G alpha (q) signalling events
- Downstream TCR signaling
- Costimulation by the CD28 family
- IRS-mediated signalling
- PIP3 activates AKT signaling
- IGF1R signaling cascade
- VEGFA-VEGFR2 Pathway
- Synthesis of PIPs at the plasma membrane
- IRS-related events triggered by IGF1R
- G beta:gamma signalling through PI3Kgamma
- PI3K events in ERBB2 signaling
- Regulation of signaling by CBL
- Downstream signaling of activated FGFR
- G alpha (12/13) signalling events
- Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
- PI Metabolism
- Innate Immune System
- Signaling by Insulin receptor
- Signalling by NGF
- Insulin receptor signalling cascade
- Cytokine Signaling in Immune system
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- IRS-related events
- NGF signalling via TRKA from the plasma membrane
- Tie2 Signaling
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- Cell surface interactions at the vascular wall
- Signaling by FGFR
- IRS-mediated signalling
- Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
- GPVI-mediated activation cascade
- Interleukin receptor SHC signaling
- Signaling by FGFR1 fusion mutants
- Constitutive Signaling by EGFRvIII
- PI3K Cascade
|
|
- Isoproterenol
- (1S,6BR,9AS,11R,11BR)-9A,11B-DIMETHYL-1-[(METHYLOXY)METHYL]-3,6,9-TRIOXO-1,6,6B,7,8,9,9A,10,11,11B-DECAHYDRO-3H-FURO[4,3,2-DE]INDENO[4,5-H][2]BENZOPYRAN-11-YL ACETATE
|
|
|
CLU and HSPD1 |
clusterin |
heat shock 60kDa protein 1 (chaperonin) |
- Response to elevated platelet cytosolic Ca2+
- Platelet degranulation
- Platelet activation, signaling and aggregation
|
- Mitochondrial protein import
|
|
|
|
|
CLU and TGFBR1 |
clusterin |
transforming growth factor, beta receptor 1 |
- Response to elevated platelet cytosolic Ca2+
- Platelet degranulation
- Platelet activation, signaling and aggregation
|
- Loss of Function of TGFBR2 in Cancer
- TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
- TGFBR2 MSI Frameshift Mutants in Cancer
- SMAD2/3 Phosphorylation Motif Mutants in Cancer
- Loss of Function of SMAD2/3 in Cancer
- TGFBR2 Kinase Domain Mutants in Cancer
- Downregulation of TGF-beta receptor signaling
- SMAD2/3 MH2 Domain Mutants in Cancer
- Loss of Function of SMAD4 in Cancer
- TGFBR1 KD Mutants in Cancer
- TGF-beta receptor signaling activates SMADs
- TGFBR1 LBD Mutants in Cancer
- Loss of Function of TGFBR1 in Cancer
- Signaling by TGF-beta Receptor Complex in Cancer
- Signaling by TGF-beta Receptor Complex
- SMAD4 MH2 Domain Mutants in Cancer
|
|
|
|
|
CLU and ELN |
clusterin |
elastin |
- Response to elevated platelet cytosolic Ca2+
- Platelet degranulation
- Platelet activation, signaling and aggregation
|
- Molecules associated with elastic fibres
- Elastic fibre formation
- Degradation of the extracellular matrix
|
|
|
|
|
CLU and TTR |
clusterin |
transthyretin |
- Response to elevated platelet cytosolic Ca2+
- Platelet degranulation
- Platelet activation, signaling and aggregation
|
- Amyloids
- Visual phototransduction
- The canonical retinoid cycle in rods (twilight vision)
- Retinoid cycle disease events
- Non-integrin membrane-ECM interactions
- Diseases associated with visual transduction
- Retinoid metabolism and transport
|
|
|
|
|