PSEN1 and RNF32 |
presenilin 1 |
ring finger protein 32 |
- Degradation of the extracellular matrix
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PSEN1 and TUBA1B |
presenilin 1 |
tubulin, alpha 1b |
- Degradation of the extracellular matrix
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- Transport of connexons to the plasma membrane
- Mitotic Prometaphase
- Organelle biogenesis and maintenance
- Axon guidance
- Hedgehog 'off' state
- Separation of Sister Chromatids
- Translocation of GLUT4 to the plasma membrane
- G2/M Transition
- L1CAM interactions
- Mitotic Anaphase
- Recycling pathway of L1
- Recruitment of NuMA to mitotic centrosomes
- Formation of tubulin folding intermediates by CCT/TriC
- Intraflagellar transport
- M Phase
- Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding
- Post-chaperonin tubulin folding pathway
- Gap junction trafficking and regulation
- MHC class II antigen presentation
- Recruitment of mitotic centrosome proteins and complexes
- Protein folding
- Gap junction assembly
- Gap junction trafficking
- Kinesins
- Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane
- Assembly of the primary cilium
- Factors involved in megakaryocyte development and platelet production
- Cell Cycle, Mitotic
- Resolution of Sister Chromatid Cohesion
- Chaperonin-mediated protein folding
- Signaling by Hedgehog
- Centrosome maturation
- Mitotic G2-G2/M phases
- Mitotic Metaphase and Anaphase
- Adaptive Immune System
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- Epothilone D
- Epothilone B
- 2-MERCAPTO-N-[1,2,3,10-TETRAMETHOXY-9-OXO-5,6,7,9-TETRAHYDRO-BENZO[A]HEPTALEN-7-YL]ACETAMIDE
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PSEN1 and RMDN3 |
presenilin 1 |
regulator of microtubule dynamics 3 |
- Degradation of the extracellular matrix
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PSEN1 and PRAM1 |
presenilin 1 |
PML-RARA regulated adaptor molecule 1 |
- Degradation of the extracellular matrix
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PSEN1 and BACE1 |
presenilin 1 |
beta-site APP-cleaving enzyme 1 |
- Degradation of the extracellular matrix
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- MMI-175
- N-[amino(imino)methyl]-2-(2,5-diphenyl-1H-pyrrol-1-yl)acetamide
- N-[(5R,14R)-5-AMINO-5,14-DIMETHYL-4-OXO-3-OXA-18-AZATRICYCLO[15.3.1.1~7,11~]DOCOSA-1(21),7(22),8,10,17,19-HEXAEN-19-YL]-N-METHYLMETHANESULFONAMIDE
- N-[amino(imino)methyl]-2-[2-(2-chlorophenyl)-4-(4-propoxyphenyl)-3-thienyl]acetamide
- 4-(4-FLUOROBENZYL)PIPERIDINE
- N-{2-methyl-5-[(6-phenylpyrimidin-4-yl)amino]phenyl}methanesulfonamide
- 6-[2-(1H-INDOL-6-YL)ETHYL]PYRIDIN-2-AMINE
- 6-[2-(3\'-METHOXYBIPHENYL-3-YL)ETHYL]PYRIDIN-2-AMINE
- N~3~-BENZYLPYRIDINE-2,3-DIAMINE
- N~3~-(3-PYRIDIN-3-YLBENZYL)PYRIDINE-2,3-DIAMINE
- N~3~-[3-(5-METHOXYPYRIDIN-3-YL)BENZYL]PYRIDINE-2,3-DIAMINE
- 4-(2-aminoethyl)-2-cyclohexylphenol
- 4-(2-aminoethyl)-2-ethylphenol
- 4-[(1S)-1-(3-fluoro-4-methoxyphenyl)-2-(2-methoxy-5-nitrophenyl)ethyl]-1H-imidazol-2-amine
- (6R)-2-amino-6-[2-(3\'-methoxybiphenyl-3-yl)ethyl]-3,6-dimethyl-5,6-dihydropyrimidin-4(3H)-one
- 2-amino-6-[2-(1H-indol-6-yl)ethyl]pyrimidin-4(3H)-one
- (2S)-1-(2,5-dimethylphenoxy)-3-morpholin-4-ylpropan-2-ol
- N-(1-benzylpiperidin-4-yl)-4-sulfanylbutanamide
- N-[1-(2,6-dimethoxybenzyl)piperidin-4-yl]-4-sulfanylbutanamide
- (2S)-4-(4-fluorobenzyl)-N-(2-sulfanylethyl)piperazine-2-carboxamide
- (2S)-4-(4-fluorobenzyl)-N-(3-sulfanylpropyl)piperazine-2-carboxamide
- N-[1-(5-bromo-2,3-dimethoxybenzyl)piperidin-4-yl]-4-sulfanylbutanamide
- (6S)-2-amino-6-(3\'-methoxybiphenyl-3-yl)-3,6-dimethyl-5,6-dihydropyrimidin-4(3H)-one
- N~3~-[3-(1H-INDOL-6-YL)BENZYL]PYRIDINE-2,3-DIAMINE
- N~3~-[5-(1H-INDOL-6-YL)-2-(PYRIDIN-2-YLMETHOXY)BENZYL]PYRIDINE-2,3-DIAMINE
- 3-(2-AMINO-6-BENZOYLQUINAZOLIN-3(4H)-YL)-N-CYCLOHEXYL-N-METHYLPROPANAMIDE
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PSEN1 and CIB1 |
presenilin 1 |
calcium and integrin binding 1 (calmyrin) |
- Degradation of the extracellular matrix
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PSEN1 and UBQLN1 |
presenilin 1 |
ubiquilin 1 |
- Degradation of the extracellular matrix
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PSEN1 and APH1A |
presenilin 1 |
APH1A gamma secretase subunit |
- Degradation of the extracellular matrix
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- Signaling by NOTCH1 HD Domain Mutants in Cancer
- Axon guidance
- Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
- Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
- Signaling by NOTCH2
- EPH-ephrin mediated repulsion of cells
- Signaling by NOTCH1
- EPH-Ephrin signaling
- Signaling by NOTCH1 in Cancer
- Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
- FBXW7 Mutants and NOTCH1 in Cancer
- Signaling by NOTCH4
- Regulated proteolysis of p75NTR
- Signalling by NGF
- Cell death signalling via NRAGE, NRIF and NADE
- Signaling by NOTCH
- p75 NTR receptor-mediated signalling
- Signaling by ERBB4
- NOTCH2 Activation and Transmission of Signal to the Nucleus
- Activated NOTCH1 Transmits Signal to the Nucleus
- Nuclear signaling by ERBB4
- NRIF signals cell death from the nucleus
- Signaling by NOTCH1 PEST Domain Mutants in Cancer
- Signaling by NOTCH3
- Constitutive Signaling by NOTCH1 PEST Domain Mutants
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PSEN1 and ICAM5 |
presenilin 1 |
intercellular adhesion molecule 5, telencephalin |
- Degradation of the extracellular matrix
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PSEN1 and APH1B |
presenilin 1 |
APH1B gamma secretase subunit |
- Degradation of the extracellular matrix
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- Signaling by NOTCH1 HD Domain Mutants in Cancer
- Axon guidance
- Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
- Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
- Signaling by NOTCH2
- EPH-ephrin mediated repulsion of cells
- Signaling by NOTCH1
- EPH-Ephrin signaling
- Signaling by NOTCH1 in Cancer
- Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
- FBXW7 Mutants and NOTCH1 in Cancer
- Signaling by NOTCH4
- Regulated proteolysis of p75NTR
- Signalling by NGF
- Cell death signalling via NRAGE, NRIF and NADE
- Signaling by NOTCH
- p75 NTR receptor-mediated signalling
- Signaling by ERBB4
- NOTCH2 Activation and Transmission of Signal to the Nucleus
- Activated NOTCH1 Transmits Signal to the Nucleus
- Nuclear signaling by ERBB4
- NRIF signals cell death from the nucleus
- Signaling by NOTCH1 PEST Domain Mutants in Cancer
- Signaling by NOTCH3
- Constitutive Signaling by NOTCH1 PEST Domain Mutants
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PSEN1 and PKP4 |
presenilin 1 |
plakophilin 4 |
- Degradation of the extracellular matrix
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PSEN1 and PSMB1 |
presenilin 1 |
proteasome (prosome, macropain) subunit, beta type, 1 |
- Degradation of the extracellular matrix
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- Hedgehog 'off' state
- misspliced GSK3beta mutants stabilize beta-catenin
- Hh ligand biogenesis disease
- T41 mutants of beta-catenin aren't phosphorylated
- Downstream signaling events of B Cell Receptor (BCR)
- Degradation of beta-catenin by the destruction complex
- Stabilization of p53
- S33 mutants of beta-catenin aren't phosphorylated
- AXIN mutants destabilize the destruction complex, activating WNT signaling
- Removal of licensing factors from origins
- Switching of origins to a post-replicative state
- Mitotic G1-G1/S phases
- Regulation of mRNA stability by proteins that bind AU-rich elements
- misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
- DNA Replication Pre-Initiation
- S45 mutants of beta-catenin aren't phosphorylated
- APC/C:Cdc20 mediated degradation of mitotic proteins
- Regulation of APC/C activators between G1/S and early anaphase
- SCF(Skp2)-mediated degradation of p27/p21
- deletions in the AMER1 gene destabilize the destruction complex
- Autodegradation of the E3 ubiquitin ligase COP1
- AMER1 mutants destabilize the destruction complex
- Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
- APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
- PCP/CE pathway
- Adaptive Immune System
- CDK-mediated phosphorylation and removal of Cdc6
- Hedgehog ligand biogenesis
- APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
- Separation of Sister Chromatids
- HIV Infection
- Ubiquitin-dependent degradation of Cyclin D
- APC truncation mutants have impaired AXIN binding
- Assembly of the pre-replicative complex
- Autodegradation of Cdh1 by Cdh1:APC/C
- p53-Dependent G1 DNA Damage Response
- S37 mutants of beta-catenin aren't phosphorylated
- XAV939 inhibits tankyrase, stabilizing AXIN
- p53-Independent DNA Damage Response
- p53-Independent G1/S DNA damage checkpoint
- G1/S DNA Damage Checkpoints
- Vpu mediated degradation of CD4
- Synthesis of DNA
- M/G1 Transition
- Ubiquitin-dependent degradation of Cyclin D1
- TCF dependent signaling in response to WNT
- SCF-beta-TrCP mediated degradation of Emi1
- degradation of AXIN
- Signaling by Hedgehog
- Regulation of mitotic cell cycle
- Degradation of GLI1 by the proteasome
- degradation of DVL
- Cell Cycle Checkpoints
- Signaling by WNT in cancer
- GLI3 is processed to GLI3R by the proteasome
- Regulation of Apoptosis
- Degradation of GLI2 by the proteasome
- Signaling by the B Cell Receptor (BCR)
- Vif-mediated degradation of APOBEC3G
- Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
- p53-Dependent G1/S DNA damage checkpoint
- truncated APC mutants destabilize the destruction complex
- TCF7L2 mutants don't bind CTBP
- Signaling by Wnt
- Cyclin E associated events during G1/S transition
- APC/C:Cdc20 mediated degradation of Securin
- AUF1 (hnRNP D0) destabilizes mRNA
- CDK-mediated phosphorylation and removal of Cdc6
- RNF mutants show enhanced WNT signaling and proliferation
- G1/S Transition
- truncations of AMER1 destabilize the destruction complex
- Processing-defective Hh variants abrogate ligand secretion
- Host Interactions of HIV factors
- phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex
- Regulation of activated PAK-2p34 by proteasome mediated degradation
- AXIN missense mutants destabilize the destruction complex
- S Phase
- APC/C-mediated degradation of cell cycle proteins
- Cyclin A:Cdk2-associated events at S phase entry
- SCF(Skp2)-mediated degradation of p27/p21
- Mitotic Metaphase and Anaphase
- Regulation of ornithine decarboxylase (ODC)
- Antigen processing: Ubiquitination & Proteasome degradation
- Orc1 removal from chromatin
- Mitotic Anaphase
- M Phase
- APC truncation mutants are not K63 polyubiquitinated
- Metabolism of amino acids and derivatives
- Hedgehog 'on' state
- Programmed Cell Death
- Class I MHC mediated antigen processing & presentation
- Regulation of DNA replication
- Cell Cycle, Mitotic
- beta-catenin independent WNT signaling
- Orc1 removal from chromatin
- Activation of NF-kappaB in B cells
- Asymmetric localization of PCP proteins
- deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling
- Cross-presentation of soluble exogenous antigens (endosomes)
- Antigen processing-Cross presentation
- CDT1 association with the CDC6:ORC:origin complex
- ER-Phagosome pathway
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PSEN1 and ITSN2 |
presenilin 1 |
intersectin 2 |
- Degradation of the extracellular matrix
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PSEN1 and RAB11A |
presenilin 1 |
RAB11A, member RAS oncogene family |
- Degradation of the extracellular matrix
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- Cargo trafficking to the periciliary membrane
- Organelle biogenesis and maintenance
- Vasopressin regulates renal water homeostasis via Aquaporins
- Translocation of GLUT4 to the plasma membrane
- VxPx cargo-targeting to cilium
- Assembly of the primary cilium
- Aquaporin-mediated transport
- Anchoring of the basal body to the plasma membrane
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PSEN1 and FBXL12 |
presenilin 1 |
F-box and leucine-rich repeat protein 12 |
- Degradation of the extracellular matrix
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PSEN1 and PSMA5 |
presenilin 1 |
proteasome (prosome, macropain) subunit, alpha type, 5 |
- Degradation of the extracellular matrix
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- Hedgehog 'off' state
- misspliced GSK3beta mutants stabilize beta-catenin
- Hh ligand biogenesis disease
- T41 mutants of beta-catenin aren't phosphorylated
- Downstream signaling events of B Cell Receptor (BCR)
- Degradation of beta-catenin by the destruction complex
- Stabilization of p53
- S33 mutants of beta-catenin aren't phosphorylated
- AXIN mutants destabilize the destruction complex, activating WNT signaling
- Removal of licensing factors from origins
- Switching of origins to a post-replicative state
- Mitotic G1-G1/S phases
- Regulation of mRNA stability by proteins that bind AU-rich elements
- misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
- DNA Replication Pre-Initiation
- S45 mutants of beta-catenin aren't phosphorylated
- APC/C:Cdc20 mediated degradation of mitotic proteins
- Regulation of APC/C activators between G1/S and early anaphase
- SCF(Skp2)-mediated degradation of p27/p21
- deletions in the AMER1 gene destabilize the destruction complex
- Autodegradation of the E3 ubiquitin ligase COP1
- AMER1 mutants destabilize the destruction complex
- Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
- APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
- PCP/CE pathway
- Adaptive Immune System
- CDK-mediated phosphorylation and removal of Cdc6
- Hedgehog ligand biogenesis
- APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
- Separation of Sister Chromatids
- HIV Infection
- Ubiquitin-dependent degradation of Cyclin D
- APC truncation mutants have impaired AXIN binding
- Assembly of the pre-replicative complex
- Autodegradation of Cdh1 by Cdh1:APC/C
- p53-Dependent G1 DNA Damage Response
- S37 mutants of beta-catenin aren't phosphorylated
- XAV939 inhibits tankyrase, stabilizing AXIN
- p53-Independent DNA Damage Response
- p53-Independent G1/S DNA damage checkpoint
- G1/S DNA Damage Checkpoints
- Vpu mediated degradation of CD4
- Synthesis of DNA
- M/G1 Transition
- Ubiquitin-dependent degradation of Cyclin D1
- TCF dependent signaling in response to WNT
- SCF-beta-TrCP mediated degradation of Emi1
- degradation of AXIN
- Signaling by Hedgehog
- Regulation of mitotic cell cycle
- Degradation of GLI1 by the proteasome
- degradation of DVL
- Cell Cycle Checkpoints
- Signaling by WNT in cancer
- GLI3 is processed to GLI3R by the proteasome
- Regulation of Apoptosis
- Degradation of GLI2 by the proteasome
- Signaling by the B Cell Receptor (BCR)
- Vif-mediated degradation of APOBEC3G
- Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
- p53-Dependent G1/S DNA damage checkpoint
- truncated APC mutants destabilize the destruction complex
- TCF7L2 mutants don't bind CTBP
- Signaling by Wnt
- Cyclin E associated events during G1/S transition
- APC/C:Cdc20 mediated degradation of Securin
- AUF1 (hnRNP D0) destabilizes mRNA
- CDK-mediated phosphorylation and removal of Cdc6
- RNF mutants show enhanced WNT signaling and proliferation
- G1/S Transition
- truncations of AMER1 destabilize the destruction complex
- Processing-defective Hh variants abrogate ligand secretion
- Host Interactions of HIV factors
- phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex
- Regulation of activated PAK-2p34 by proteasome mediated degradation
- AXIN missense mutants destabilize the destruction complex
- S Phase
- APC/C-mediated degradation of cell cycle proteins
- Cyclin A:Cdk2-associated events at S phase entry
- SCF(Skp2)-mediated degradation of p27/p21
- Mitotic Metaphase and Anaphase
- Regulation of ornithine decarboxylase (ODC)
- Antigen processing: Ubiquitination & Proteasome degradation
- Orc1 removal from chromatin
- Mitotic Anaphase
- M Phase
- APC truncation mutants are not K63 polyubiquitinated
- Metabolism of amino acids and derivatives
- Hedgehog 'on' state
- Programmed Cell Death
- Class I MHC mediated antigen processing & presentation
- Regulation of DNA replication
- Cell Cycle, Mitotic
- beta-catenin independent WNT signaling
- Orc1 removal from chromatin
- Activation of NF-kappaB in B cells
- Asymmetric localization of PCP proteins
- deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling
- Cross-presentation of soluble exogenous antigens (endosomes)
- Antigen processing-Cross presentation
- CDT1 association with the CDC6:ORC:origin complex
- ER-Phagosome pathway
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PSEN1 and KCNIP4 |
presenilin 1 |
Kv channel interacting protein 4 |
- Degradation of the extracellular matrix
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PSEN1 and PRDX2 |
presenilin 1 |
peroxiredoxin 2 |
- Degradation of the extracellular matrix
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- Detoxification of Reactive Oxygen Species
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- 3-Sulfinoalanine
- N-Carbamoyl-Alanine
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PSEN1 and SCAF11 |
presenilin 1 |
SR-related CTD-associated factor 11 |
- Degradation of the extracellular matrix
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PSEN1 and TDP2 |
presenilin 1 |
tyrosyl-DNA phosphodiesterase 2 |
- Degradation of the extracellular matrix
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