SCNN1A and HECW1 |
sodium channel, non voltage gated 1 alpha subunit |
HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1 |
- Ion channel transport
- Stimuli-sensing channels
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- misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
- TCF dependent signaling in response to WNT
- RNF mutants show enhanced WNT signaling and proliferation
- XAV939 inhibits tankyrase, stabilizing AXIN
- degradation of DVL
- Signaling by Wnt
- Signaling by WNT in cancer
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SMARCA4 and STK11 |
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 |
serine/threonine kinase 11 |
- Chromatin modifying enzymes
- Chromatin organization
- misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
- TCF dependent signaling in response to WNT
- RNF mutants show enhanced WNT signaling and proliferation
- formation of the beta-catenin:TCF transactivating complex
- XAV939 inhibits tankyrase, stabilizing AXIN
- Signaling by Wnt
- Signaling by WNT in cancer
- RMTs methylate histone arginines
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- Insulin receptor signalling cascade
- Integration of energy metabolism
- IRS-mediated signalling
- Regulation of AMPK activity via LKB1
- mTOR signalling
- IRS-related events
- mTOR signalling
- IGF1R signaling cascade
- IRS-related events triggered by IGF1R
- IRS-mediated signalling
- Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
- Energy dependent regulation of mTOR by LKB1-AMPK
- AMPK inhibits chREBP transcriptional activation activity
- PKB-mediated events
- PI3K Cascade
- PKB-mediated events
- PI3K Cascade
- Signaling by Insulin receptor
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STK11 and CDC37 |
serine/threonine kinase 11 |
cell division cycle 37 |
- Insulin receptor signalling cascade
- Integration of energy metabolism
- IRS-mediated signalling
- Regulation of AMPK activity via LKB1
- mTOR signalling
- IRS-related events
- mTOR signalling
- IGF1R signaling cascade
- IRS-related events triggered by IGF1R
- IRS-mediated signalling
- Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
- Energy dependent regulation of mTOR by LKB1-AMPK
- AMPK inhibits chREBP transcriptional activation activity
- PKB-mediated events
- PI3K Cascade
- PKB-mediated events
- PI3K Cascade
- Signaling by Insulin receptor
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- Signaling by ERBB2
- Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
- Signaling by EGFR in Cancer
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- Signaling by EGFRvIII in Cancer
- Constitutive Signaling by EGFRvIII
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STK11 and CAB39 |
serine/threonine kinase 11 |
calcium binding protein 39 |
- Insulin receptor signalling cascade
- Integration of energy metabolism
- IRS-mediated signalling
- Regulation of AMPK activity via LKB1
- mTOR signalling
- IRS-related events
- mTOR signalling
- IGF1R signaling cascade
- IRS-related events triggered by IGF1R
- IRS-mediated signalling
- Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
- Energy dependent regulation of mTOR by LKB1-AMPK
- AMPK inhibits chREBP transcriptional activation activity
- PKB-mediated events
- PI3K Cascade
- PKB-mediated events
- PI3K Cascade
- Signaling by Insulin receptor
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- Insulin receptor signalling cascade
- IRS-mediated signalling
- Regulation of AMPK activity via LKB1
- mTOR signalling
- IRS-related events
- mTOR signalling
- IGF1R signaling cascade
- IRS-related events triggered by IGF1R
- IRS-mediated signalling
- Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
- Energy dependent regulation of mTOR by LKB1-AMPK
- PKB-mediated events
- PI3K Cascade
- PKB-mediated events
- PI3K Cascade
- Signaling by Insulin receptor
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STK11 and STRADB |
serine/threonine kinase 11 |
STE20-related kinase adaptor beta |
- Insulin receptor signalling cascade
- Integration of energy metabolism
- IRS-mediated signalling
- Regulation of AMPK activity via LKB1
- mTOR signalling
- IRS-related events
- mTOR signalling
- IGF1R signaling cascade
- IRS-related events triggered by IGF1R
- IRS-mediated signalling
- Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
- Energy dependent regulation of mTOR by LKB1-AMPK
- AMPK inhibits chREBP transcriptional activation activity
- PKB-mediated events
- PI3K Cascade
- PKB-mediated events
- PI3K Cascade
- Signaling by Insulin receptor
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- Insulin receptor signalling cascade
- IRS-mediated signalling
- Regulation of AMPK activity via LKB1
- mTOR signalling
- IRS-related events
- mTOR signalling
- IGF1R signaling cascade
- IRS-related events triggered by IGF1R
- IRS-mediated signalling
- Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
- Energy dependent regulation of mTOR by LKB1-AMPK
- PKB-mediated events
- PI3K Cascade
- PKB-mediated events
- PI3K Cascade
- Signaling by Insulin receptor
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STK11 and UBE2D2 |
serine/threonine kinase 11 |
ubiquitin-conjugating enzyme E2D 2 |
- Insulin receptor signalling cascade
- Integration of energy metabolism
- IRS-mediated signalling
- Regulation of AMPK activity via LKB1
- mTOR signalling
- IRS-related events
- mTOR signalling
- IGF1R signaling cascade
- IRS-related events triggered by IGF1R
- IRS-mediated signalling
- Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
- Energy dependent regulation of mTOR by LKB1-AMPK
- AMPK inhibits chREBP transcriptional activation activity
- PKB-mediated events
- PI3K Cascade
- PKB-mediated events
- PI3K Cascade
- Signaling by Insulin receptor
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- Cellular response to hypoxia
- Regulation of Hypoxia-inducible Factor (HIF) by oxygen
- Antigen processing: Ubiquitination & Proteasome degradation
- Negative regulators of RIG-I/MDA5 signaling
- Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
- IKK complex recruitment mediated by RIP1
- TRIF-mediated TLR3/TLR4 signaling
- MyD88-independent cascade
- Activated TLR4 signalling
- RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
- Toll-Like Receptors Cascades
- Toll Like Receptor 4 (TLR4) Cascade
- Toll Like Receptor 3 (TLR3) Cascade
- Class I MHC mediated antigen processing & presentation
- Innate Immune System
- Adaptive Immune System
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STK11 and RPS6KA5 |
serine/threonine kinase 11 |
ribosomal protein S6 kinase, 90kDa, polypeptide 5 |
- Insulin receptor signalling cascade
- Integration of energy metabolism
- IRS-mediated signalling
- Regulation of AMPK activity via LKB1
- mTOR signalling
- IRS-related events
- mTOR signalling
- IGF1R signaling cascade
- IRS-related events triggered by IGF1R
- IRS-mediated signalling
- Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
- Energy dependent regulation of mTOR by LKB1-AMPK
- AMPK inhibits chREBP transcriptional activation activity
- PKB-mediated events
- PI3K Cascade
- PKB-mediated events
- PI3K Cascade
- Signaling by Insulin receptor
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- CREB phosphorylation
- Axon guidance
- Toll Like Receptor 7/8 (TLR7/8) Cascade
- CREB phosphorylation
- L1CAM interactions
- Recycling pathway of L1
- Toll Like Receptor TLR6:TLR2 Cascade
- Toll Like Receptor TLR1:TLR2 Cascade
- Activated TLR4 signalling
- MyD88 cascade initiated on plasma membrane
- Toll Like Receptor 5 (TLR5) Cascade
- MyD88 dependent cascade initiated on endosome
- MyD88:Mal cascade initiated on plasma membrane
- TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
- NCAM signaling for neurite out-growth
- Toll Like Receptor 9 (TLR9) Cascade
- ERK/MAPK targets
- Innate Immune System
- Signalling by NGF
- MAP kinase activation in TLR cascade
- TRIF-mediated TLR3/TLR4 signaling
- NGF signalling via TRKA from the plasma membrane
- MyD88-independent cascade
- Toll Like Receptor 2 (TLR2) Cascade
- Toll-Like Receptors Cascades
- Toll Like Receptor 10 (TLR10) Cascade
- Toll Like Receptor 4 (TLR4) Cascade
- ERK/MAPK targets
- Toll Like Receptor 3 (TLR3) Cascade
- MAPK targets/ Nuclear events mediated by MAP kinases
- Nuclear Events (kinase and transcription factor activation)
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STK11 and MOB4 |
serine/threonine kinase 11 |
MOB family member 4, phocein |
- Insulin receptor signalling cascade
- Integration of energy metabolism
- IRS-mediated signalling
- Regulation of AMPK activity via LKB1
- mTOR signalling
- IRS-related events
- mTOR signalling
- IGF1R signaling cascade
- IRS-related events triggered by IGF1R
- IRS-mediated signalling
- Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
- Energy dependent regulation of mTOR by LKB1-AMPK
- AMPK inhibits chREBP transcriptional activation activity
- PKB-mediated events
- PI3K Cascade
- PKB-mediated events
- PI3K Cascade
- Signaling by Insulin receptor
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STK11 and MAPRE1 |
serine/threonine kinase 11 |
microtubule-associated protein, RP/EB family, member 1 |
- Insulin receptor signalling cascade
- Integration of energy metabolism
- IRS-mediated signalling
- Regulation of AMPK activity via LKB1
- mTOR signalling
- IRS-related events
- mTOR signalling
- IGF1R signaling cascade
- IRS-related events triggered by IGF1R
- IRS-mediated signalling
- Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
- Energy dependent regulation of mTOR by LKB1-AMPK
- AMPK inhibits chREBP transcriptional activation activity
- PKB-mediated events
- PI3K Cascade
- PKB-mediated events
- PI3K Cascade
- Signaling by Insulin receptor
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- Mitotic Prometaphase
- Organelle biogenesis and maintenance
- Separation of Sister Chromatids
- Assembly of the primary cilium
- G2/M Transition
- Mitotic Anaphase
- Regulation of PLK1 Activity at G2/M Transition
- Anchoring of the basal body to the plasma membrane
- M Phase
- Cell Cycle, Mitotic
- Loss of proteins required for interphase microtubule organization from the centrosome
- Resolution of Sister Chromatid Cohesion
- Loss of Nlp from mitotic centrosomes
- Centrosome maturation
- Mitotic G2-G2/M phases
- Mitotic Metaphase and Anaphase
- Recruitment of mitotic centrosome proteins and complexes
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STK11 and STRADA |
serine/threonine kinase 11 |
STE20-related kinase adaptor alpha |
- Insulin receptor signalling cascade
- Integration of energy metabolism
- IRS-mediated signalling
- Regulation of AMPK activity via LKB1
- mTOR signalling
- IRS-related events
- mTOR signalling
- IGF1R signaling cascade
- IRS-related events triggered by IGF1R
- IRS-mediated signalling
- Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
- Energy dependent regulation of mTOR by LKB1-AMPK
- AMPK inhibits chREBP transcriptional activation activity
- PKB-mediated events
- PI3K Cascade
- PKB-mediated events
- PI3K Cascade
- Signaling by Insulin receptor
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- Insulin receptor signalling cascade
- IRS-mediated signalling
- Regulation of AMPK activity via LKB1
- mTOR signalling
- IRS-related events
- mTOR signalling
- IGF1R signaling cascade
- IRS-related events triggered by IGF1R
- IRS-mediated signalling
- Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
- Energy dependent regulation of mTOR by LKB1-AMPK
- PKB-mediated events
- PI3K Cascade
- PKB-mediated events
- PI3K Cascade
- Signaling by Insulin receptor
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STK11 and TNIP2 |
serine/threonine kinase 11 |
TNFAIP3 interacting protein 2 |
- Insulin receptor signalling cascade
- Integration of energy metabolism
- IRS-mediated signalling
- Regulation of AMPK activity via LKB1
- mTOR signalling
- IRS-related events
- mTOR signalling
- IGF1R signaling cascade
- IRS-related events triggered by IGF1R
- IRS-mediated signalling
- Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
- Energy dependent regulation of mTOR by LKB1-AMPK
- AMPK inhibits chREBP transcriptional activation activity
- PKB-mediated events
- PI3K Cascade
- PKB-mediated events
- PI3K Cascade
- Signaling by Insulin receptor
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- Signaling by Interleukins
- Cytokine Signaling in Immune system
- Interleukin-1 signaling
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STK11 and MARK4 |
serine/threonine kinase 11 |
MAP/microtubule affinity-regulating kinase 4 |
- Insulin receptor signalling cascade
- Integration of energy metabolism
- IRS-mediated signalling
- Regulation of AMPK activity via LKB1
- mTOR signalling
- IRS-related events
- mTOR signalling
- IGF1R signaling cascade
- IRS-related events triggered by IGF1R
- IRS-mediated signalling
- Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
- Energy dependent regulation of mTOR by LKB1-AMPK
- AMPK inhibits chREBP transcriptional activation activity
- PKB-mediated events
- PI3K Cascade
- PKB-mediated events
- PI3K Cascade
- Signaling by Insulin receptor
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- Organelle biogenesis and maintenance
- Assembly of the primary cilium
- Anchoring of the basal body to the plasma membrane
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STK11 and SPDEF |
serine/threonine kinase 11 |
SAM pointed domain containing ETS transcription factor |
- Insulin receptor signalling cascade
- Integration of energy metabolism
- IRS-mediated signalling
- Regulation of AMPK activity via LKB1
- mTOR signalling
- IRS-related events
- mTOR signalling
- IGF1R signaling cascade
- IRS-related events triggered by IGF1R
- IRS-mediated signalling
- Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
- Energy dependent regulation of mTOR by LKB1-AMPK
- AMPK inhibits chREBP transcriptional activation activity
- PKB-mediated events
- PI3K Cascade
- PKB-mediated events
- PI3K Cascade
- Signaling by Insulin receptor
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STK11 and SNRK |
serine/threonine kinase 11 |
SNF related kinase |
- Insulin receptor signalling cascade
- Integration of energy metabolism
- IRS-mediated signalling
- Regulation of AMPK activity via LKB1
- mTOR signalling
- IRS-related events
- mTOR signalling
- IGF1R signaling cascade
- IRS-related events triggered by IGF1R
- IRS-mediated signalling
- Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
- Energy dependent regulation of mTOR by LKB1-AMPK
- AMPK inhibits chREBP transcriptional activation activity
- PKB-mediated events
- PI3K Cascade
- PKB-mediated events
- PI3K Cascade
- Signaling by Insulin receptor
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STK11 and SIK1 |
serine/threonine kinase 11 |
salt-inducible kinase 1 |
- Insulin receptor signalling cascade
- Integration of energy metabolism
- IRS-mediated signalling
- Regulation of AMPK activity via LKB1
- mTOR signalling
- IRS-related events
- mTOR signalling
- IGF1R signaling cascade
- IRS-related events triggered by IGF1R
- IRS-mediated signalling
- Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
- Energy dependent regulation of mTOR by LKB1-AMPK
- AMPK inhibits chREBP transcriptional activation activity
- PKB-mediated events
- PI3K Cascade
- PKB-mediated events
- PI3K Cascade
- Signaling by Insulin receptor
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STK11 and PARD3 |
serine/threonine kinase 11 |
par-3 family cell polarity regulator |
- Insulin receptor signalling cascade
- Integration of energy metabolism
- IRS-mediated signalling
- Regulation of AMPK activity via LKB1
- mTOR signalling
- IRS-related events
- mTOR signalling
- IGF1R signaling cascade
- IRS-related events triggered by IGF1R
- IRS-mediated signalling
- Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
- Energy dependent regulation of mTOR by LKB1-AMPK
- AMPK inhibits chREBP transcriptional activation activity
- PKB-mediated events
- PI3K Cascade
- PKB-mediated events
- PI3K Cascade
- Signaling by Insulin receptor
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- Loss of Function of TGFBR2 in Cancer
- Cell junction organization
- TGFBR2 MSI Frameshift Mutants in Cancer
- TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
- SMAD2/3 Phosphorylation Motif Mutants in Cancer
- Tight junction interactions
- Loss of Function of SMAD2/3 in Cancer
- TGFBR2 Kinase Domain Mutants in Cancer
- SMAD2/3 MH2 Domain Mutants in Cancer
- Loss of Function of SMAD4 in Cancer
- TGFBR1 KD Mutants in Cancer
- TGFBR1 LBD Mutants in Cancer
- Loss of Function of TGFBR1 in Cancer
- Cell-cell junction organization
- Signaling by TGF-beta Receptor Complex
- Signaling by TGF-beta Receptor Complex in Cancer
- SMAD4 MH2 Domain Mutants in Cancer
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STK11 and STK11IP |
serine/threonine kinase 11 |
serine/threonine kinase 11 interacting protein |
- Insulin receptor signalling cascade
- Integration of energy metabolism
- IRS-mediated signalling
- Regulation of AMPK activity via LKB1
- mTOR signalling
- IRS-related events
- mTOR signalling
- IGF1R signaling cascade
- IRS-related events triggered by IGF1R
- IRS-mediated signalling
- Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
- Energy dependent regulation of mTOR by LKB1-AMPK
- AMPK inhibits chREBP transcriptional activation activity
- PKB-mediated events
- PI3K Cascade
- PKB-mediated events
- PI3K Cascade
- Signaling by Insulin receptor
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STK11 and SIRT1 |
serine/threonine kinase 11 |
sirtuin 1 |
- Insulin receptor signalling cascade
- Integration of energy metabolism
- IRS-mediated signalling
- Regulation of AMPK activity via LKB1
- mTOR signalling
- IRS-related events
- mTOR signalling
- IGF1R signaling cascade
- IRS-related events triggered by IGF1R
- IRS-mediated signalling
- Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
- Energy dependent regulation of mTOR by LKB1-AMPK
- AMPK inhibits chREBP transcriptional activation activity
- PKB-mediated events
- PI3K Cascade
- PKB-mediated events
- PI3K Cascade
- Signaling by Insulin receptor
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- Epigenetic regulation of gene expression
- Negative epigenetic regulation of rRNA expression
- SIRT1 negatively regulates rRNA Expression
- Cellular response to heat stress
- Regulation of HSF1-mediated heat shock response
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STK24 and LRRK2 |
serine/threonine kinase 24 |
leucine-rich repeat kinase 2 |
- Apoptotic cleavage of cellular proteins
- Programmed Cell Death
- Apoptotic execution phase
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TNFRSF11A and GAB2 |
tumor necrosis factor receptor superfamily, member 11a, NFKB activator |
GRB2-associated binding protein 2 |
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- Signaling by GPCR
- Signaling by FGFR in disease
- G-protein beta:gamma signalling
- Cytokine Signaling in Immune system
- Role of LAT2/NTAL/LAB on calcium mobilization
- Signaling by SCF-KIT
- Signaling by Interleukins
- GPCR downstream signaling
- Interleukin receptor SHC signaling
- G beta:gamma signalling through PI3Kgamma
- Signaling by FGFR1 mutants
- Interleukin receptor SHC signaling
- Fc epsilon receptor (FCERI) signaling
- Signaling by FGFR mutants
- GPVI-mediated activation cascade
- Interleukin-2 signaling
- Signaling by FGFR1 fusion mutants
- Platelet activation, signaling and aggregation
- Interleukin-3, 5 and GM-CSF signaling
- Innate Immune System
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