ETV4 and STK11

Number of citations of the paper that reports this interaction (PMID 16912160)
14

Data Source:
BioGRID (enzymatic study)

		ETV4	STK11
Gene Name		ets variant 4	serine/threonine kinase 11
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleolus	Nucleus Cytoplasm Mitochondrion Cytosol Membrane TCR Signalosome Extracellular Vesicular Exosome
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Protein Binding	Magnesium Ion Binding P53 Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding LRR Domain Binding Protein Kinase Activator Activity Protein Complex Binding
	Biological Process	Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Motor Neuron Axon Guidance Cell Differentiation Negative Regulation Of Mammary Gland Epithelial Cell Proliferation Positive Regulation Of Transcription From RNA Polymerase II Promoter Stem Cell Differentiation Branching Involved In Mammary Gland Duct Morphogenesis Regulation Of Branching Involved In Mammary Gland Duct Morphogenesis	Regulation Of Cell Growth Tissue Homeostasis Vasculature Development Energy Reserve Metabolic Process Protein Phosphorylation Autophagy Cellular Response To DNA Damage Stimulus Cell Cycle Arrest Spermatid Development Axonogenesis Negative Regulation Of Cell Proliferation Insulin Receptor Signaling Pathway Response To Ionizing Radiation Establishment Of Cell Polarity Regulation Of Wnt Signaling Pathway Negative Regulation Of Cell Growth Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Activation Of Protein Kinase Activity Response To Glucagon Response To Lipid TCR Signalosome Assembly Regulation Of Fatty Acid Biosynthetic Process Glucose Homeostasis Anoikis Small Molecule Metabolic Process Positive Thymic T Cell Selection Positive Regulation Of Gluconeogenesis Protein Autophosphorylation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Axonogenesis T Cell Receptor Signaling Pathway Protein Heterooligomerization Golgi Localization Regulation Of Protein Kinase B Signaling Canonical Wnt Signaling Pathway Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Cellular Response To UV-B Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator
Pathways			Insulin receptor signalling cascade Integration of energy metabolism IRS-mediated signalling Regulation of AMPK activity via LKB1 mTOR signalling IRS-related events mTOR signalling IGF1R signaling cascade IRS-related events triggered by IGF1R IRS-mediated signalling Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) Energy dependent regulation of mTOR by LKB1-AMPK AMPK inhibits chREBP transcriptional activation activity PKB-mediated events PI3K Cascade PKB-mediated events PI3K Cascade Signaling by Insulin receptor
Drugs
Diseases
GWAS			Alzheimer's disease ( 22005930)
Protein-Protein Interactions		11 interactors: APP ATXN1 EP300 HOXD4 HTT JUN SAE1 SRF STK11 SUMO1 UBA2	29 interactors: APP ATM CAB39 CDC37 ETV4 MAPRE1 MARK1 MARK2 MARK4 MOB4 PARD3 PRKAA1 PRKAA2 PRKACA PTEN RPS6KA3 RPS6KA5 RPS6KB1 SIK1 SIRT1 SMARCA4 SNRK SPDEF STK11IP STRADA STRADB TNIP2 TP53 UBE2D2
Entrez ID		2118	6794
HPRD ID		02833	03740
Ensembl ID		ENSG00000175832	ENSG00000118046
Uniprot IDs		P43268	Q15831
PDB IDs			2WTK
Enriched GO Terms of Interacting Partners?		Learning Positive Regulation Of Metabolic Process Associative Learning Learning Or Memory Cognition Response To Abiotic Stimulus Protein Sumoylation SMT3-dependent Protein Catabolic Process Response To Radiation Single-organism Behavior Regulation Of Cell Cycle Visual Learning Regulation Of Metabolic Process Visual Behavior Behavior Peptidyl-lysine Modification Regulation Of Binding Positive Regulation By Host Of Viral Transcription Positive Thymic T Cell Selection Regulation Of Signaling Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Response To Light Stimulus Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Neuron Development Apoptotic Process Thymic T Cell Selection Programmed Cell Death Positive Regulation Of Transcription From RNA Polymerase II Promoter Protein Localization To Nucleus Circadian Rhythm Cell Death Death Regulation Of Signal Transduction Developmental Process Positive T Cell Selection Cellular Response To Organic Substance Regulation Of Neuron Differentiation Neuron Differentiation Cellular Metabolic Process Post-translational Protein Modification Neurological System Process Interaction With Symbiont Organ Development Regulation Of Growth Locomotory Behavior Immune System Process T Cell Selection Negative Regulation Of Cell Proliferation	Regulation Of Cell Cycle Protein Phosphorylation Cell Cycle Cellular Protein Modification Process Phosphorylation Positive Regulation Of Cellular Metabolic Process Regulation Of Protein Phosphorylation Regulation Of Cellular Protein Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Cellular Protein Metabolic Process Cell Cycle Arrest Regulation Of Protein Metabolic Process Intracellular Signal Transduction Regulation Of Cell Death Histone Phosphorylation Regulation Of Mitotic Cell Cycle Cell Cycle Process Regulation Of Phosphorylation Negative Regulation Of Cell Cycle Positive Regulation Of Cellular Protein Metabolic Process Phosphate-containing Compound Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Apoptotic Process Positive Regulation Of Metabolic Process Regulation Of Cellular Ketone Metabolic Process Regulation Of Phosphorus Metabolic Process Positive Regulation Of Protein Metabolic Process Histone-serine Phosphorylation Cellular Response To Organic Substance Regulation Of Protein Kinase Activity Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Kinase Activity Insulin Receptor Signaling Pathway Protein Metabolic Process Cell Differentiation Signaling Response To Insulin Response To Peptide Hormone Cell Communication Response To External Stimulus Positive Regulation Of Protein Modification Process Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Cellular Response To Peptide Hormone Stimulus Response To Peptide Cellular Response To Peptide Positive Regulation Of Protein Phosphorylation Negative Regulation Of Cell Death Regulation Of Signal Transduction
Tagcloud ?		array ccl7 developing distant downregulated ets itga7 kiss1 luminal lymphovascular messenger metastasis mmp2 mmp7 nr4a3 overexpressed overexpression predictor probability ribonucleic shorter sstr timp3 tissue tnbc triple upregulated variant verify	alleles atm brca1 brca2 brip1 cdh1 chek2 confer contributing contributive fashion hereditary influences lifetime offers otherwise palb2 penetrance penetrant personal polygenic predisposing predisposition quite snp suggestive suspicion unlikely venue
Tagcloud (Difference) ?		array ccl7 developing distant downregulated ets itga7 kiss1 luminal lymphovascular messenger metastasis mmp2 mmp7 nr4a3 overexpressed overexpression predictor probability ribonucleic shorter sstr timp3 tissue tnbc triple upregulated variant verify	alleles atm brca1 brca2 brip1 cdh1 chek2 confer contributing contributive fashion hereditary influences lifetime offers otherwise palb2 penetrance penetrant personal polygenic predisposing predisposition quite snp suggestive suspicion unlikely venue
Tagcloud (Intersection) ?