HNRNPDL and SNRPC

Number of citations of the paper that reports this interaction (PubMedID 35271311)
106

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		HNRNPDL	SNRPC
Description		heterogeneous nuclear ribonucleoprotein D like	small nuclear ribonucleoprotein polypeptide C
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Spliceosomal Complex Cytoplasm Cytosol	Commitment Complex Nucleus Nucleoplasm Spliceosomal Complex U1 SnRNP Cajal Body U2-type Prespliceosome Ribonucleoprotein Complex
	Molecular Function	Nucleic Acid Binding DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding RNA Binding Protein Binding Poly(A) Binding Poly(G) Binding	Nucleic Acid Binding RNA Binding Single-stranded RNA Binding MRNA Binding Protein Binding Zinc Ion Binding U1 SnRNA Binding Pre-mRNA 5'-splice Site Binding Protein Homodimerization Activity Metal Ion Binding
	Biological Process	RNA Processing Regulation Of Gene Expression	Spliceosomal SnRNP Assembly MRNA 5'-splice Site Recognition MRNA Splicing, Via Spliceosome
Pathways		Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS			Appendicular lean mass ( 33097823) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) HDL cholesterol ( 25961943) Hip circumference adjusted for BMI ( 34021172) Low density lipoprotein cholesterol levels ( 32154731) Multisite chronic pain ( 33830993) Myocardial infarction ( 33532862) Obese vs. thin ( 30677029) Refractive error ( 32231278) Systemic lupus erythematosus ( 24871463)
Interacting Genes		10 interacting genes: CEBPA CSNK2A1 ERG HGS HMGA1 IL7R LRP1 NEIL3 OGT SNRPC	85 interacting genes: ACTMAP AGGF1 AKAP8L ANKRD10 ARHGAP9 BAG4 BCAS2 BOLL CPSF7 CREM CYSRT1 DAZAP2 DDX42 DMRTB1 ECM1 EWSR1 EXOSC8 EYA2 FAM168A FAM168B FHL3 FOXP1 FUBP1 GIGYF1 GOLGA2 HNRNPDL HNRNPF HNRNPH1 HNRNPH2 HNRNPUL1 HOXA1 HSD17B14 INTS11 JMJD7 KHDRBS3 KLF1 KRT31 KRTAP11-1 KRTAP13-2 KRTAP19-2 KRTAP19-5 KRTAP19-6 KRTAP21-2 KRTAP22-1 KRTAP6-2 KRTAP6-3 KRTAP7-1 KRTAP8-1 MAGED1 METTL27 MGAT5B MKRN3 NCAPH2 NCKIPSD ODAM PLA2G10 PRDM14 PRR20A PRR20B PRR20C PRR20D PRR20E PSMA3 QKI RAMAC RBFOX2 RBM11 RBM4 RBPMS RERE RFX6 RNF31 RUNX1 SEC23B SNRNP70 SPAG8 SS18L1 STH TENT5A TLE5 TRIB3 UFSP1 WDR77 WWOX WWP2
Entrez ID		9987	6631
HPRD ID		06185	04630
Ensembl ID		ENSG00000152795	ENSG00000124562
Uniprot IDs		A0A087WUK2 O14979	P09234 Q5TAL4
PDB IDs		7ZIR	2VRD 3CW1 4PJO 6ELD 6QX9 7VPX
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Catabolic Process Protein Localization To Vacuole DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Sin3-type Complex Vacuolar Transport Macroautophagy Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Base-excision Repair Positive Regulation Of Protein Catabolic Process Nucleoplasm Negative Regulation Of Translational Initiation Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Signal Transduction RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Autophagy Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Establishment Of Protein Localization To Vacuole Negative Regulation Of Proteasomal Protein Catabolic Process Protein Targeting To Vacuole Positive Regulation Of Transcytosis Alpha-2 Macroglobulin Receptor Activity Apolipoprotein Receptor Activity Protein Localization To Lysosome Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly MCM Complex Binding Receptor Internalization Regulation Of Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Protein Metabolic Process Regulation Of Gene Expression Chromatin DNA Binding Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Macromolecule Metabolic Process Regulation Of Proteolysis Response To Vitamin B2 C/EBP Complex Regulation Of Protein Metabolic Process Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Interleukin-7 Receptor Activity Positive Regulation Of Reverse Cholesterol Transport Regulation Of Transcytosis Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Cell Population Proliferation	Intermediate Filament Regulation Of RNA Splicing Nucleic Acid Binding Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing Regulation Of MRNA Metabolic Process RNA Binding MRNA Processing RNA Processing MRNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Protein Binding RNA Splicing Regulation Of Primary Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Alternative MRNA Splicing, Via Spliceosome Regulation Of Gene Expression MRNA Binding Regulation Of Macromolecule Metabolic Process Transcription Coactivator Activity Nucleus Nucleoplasm Identical Protein Binding Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Positive Regulation Of Metabolic Process Regulation Of DNA-templated Transcription Cytosol Regulation Of RNA Biosynthetic Process Positive Regulation Of Biosynthetic Process
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