FGF21 and KLB

Number of citations of the paper that reports this interaction (PubMedID 19059246)
0

Data Source:
HPRD (in vitro)

		FGF21	KLB
Description		fibroblast growth factor 21	klotho beta
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm	Plasma Membrane Membrane
	Molecular Function	Fibroblast Growth Factor Receptor Binding Protein Binding Growth Factor Activity	Hydrolase Activity, Hydrolyzing O-glycosyl Compounds Fibroblast Growth Factor Receptor Binding Protein Binding Fibroblast Growth Factor Binding
	Biological Process	Signal Transduction Cell-cell Signaling Positive Regulation Of Cell Population Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Low-density Lipoprotein Particle Clearance Neurogenesis Regulation Of Cell Migration Positive Regulation Of MAPK Cascade Positive Regulation Of D-glucose Import Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of MAPKKK Cascade By Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Cold-induced Thermogenesis	Carbohydrate Metabolic Process Positive Regulation Of Cell Population Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of MAPKKK Cascade By Fibroblast Growth Factor Receptor Signaling Pathway
Pathways		Cellular hexose transport Assembly of active LPL and LIPC lipase complexes	PI3K Cascade PIP3 activates AKT signaling betaKlotho-mediated ligand binding Constitutive Signaling by Aberrant PI3K in Cancer Phospholipase C-mediated cascade; FGFR4 FRS-mediated FGFR4 signaling SHC-mediated cascade:FGFR4 PI-3K cascade:FGFR4 Negative regulation of FGFR4 signaling RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Drugs
Diseases
GWAS		Bipolar disorder ( 21926972) Breakfast cereal skipping frequency ( 31190057) Breakfast skipping ( 31190057) Cooked vegetable consumption ( 32066663) Dietary macronutrient intake ( 23372041 23636237 29988085) Fish- and plant-related diet ( 32066663) Fruit consumption ( 32066663) Meat-related diet ( 32066663) Non-oily fish consumption ( 32066663) Oily fish consumption ( 32066663) Pancreas volume ( 34128465) Pork consumption ( 32066663) Processed meat consumption ( 32066663) Relative carbohydrate intake ( 32393786) Relative protein intake ( 32393786) Relative sugar intake ( 32393786) Resting metabolic rate ( 28476931) Retinal vascular caliber ( 21060863) Triglyceride levels ( 32154731 32203549) Triglycerides ( 30275531) Urinary sodium excretion ( 31409800)	Alcohol consumption ( 28937693 27911795 31358974) Alcohol consumption (drinks per week) ( 28485404 31959922 30643258 30679032) Alcohol consumption (heavy vs. light/non-drinkers) ( 31998841) Alcohol consumption in current drinkers ( 28937693) Alcohol use disorder (consumption score) ( 33861876 30940813 30336701) Alcohol use disorder (dependence and problematic use scores) ( 30336701) Alcohol use disorder (total score) ( 30336701) Asthma ( 30929738) Asthma (adult onset) ( 30929738) Bitter alcoholic beverage consumption ( 31046077) Blood urea nitrogen levels ( 31152163) Problematic alcohol use ( 32451486) Pulse pressure ( 30578418) Urate levels ( 31578528)
Interacting Genes		9 interacting genes: CDC25A CDH7 KLB MAPK7 NEDD4 SGTA SGTB TNS2 YPEL3	2 interacting genes: FGF21 FGFR1
Entrez ID		26291	152831
HPRD ID		09447	14097
Ensembl ID		ENSG00000105550	ENSG00000134962
Uniprot IDs		Q9NSA1	B4DYH5 Q86Z14
PDB IDs		5VAQ 6M6E 6M6F	5VAK 5VAN 5VAQ 5WI9 6NFJ
Enriched GO Terms of Interacting Partners?		TRC Complex Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Protein Targeting Establishment Of Protein Localization To Endoplasmic Reticulum Protein Targeting To ER Establishment Of Protein Localization To Organelle Formation Of Structure Involved In A Symbiotic Process Protein Targeting To Membrane	Positive Regulation Of MAPKKK Cascade By Fibroblast Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Neurogenesis Positive Regulation Of Mitotic Cell Cycle DNA Replication Positive Regulation Of Parathyroid Hormone Secretion Fibroblast Growth Factor Receptor Signaling Pathway Involved In Orbitofrontal Cortex Development Receptor-receptor Interaction Ventricular Zone Neuroblast Division Regulation Of Mitotic Cell Cycle DNA Replication Diphosphate Metabolic Process Regulation Of Branching Involved In Salivary Gland Morphogenesis By Mesenchymal-epithelial Signaling Orbitofrontal Cortex Development Negative Regulation Of Fibroblast Growth Factor Production Positive Regulation Of Phospholipase Activity Regulation Of Lateral Mesodermal Cell Fate Specification Vitamin D3 Metabolic Process Lung-associated Mesenchyme Development Regulation Of Branching Involved In Salivary Gland Morphogenesis Outer Ear Morphogenesis Positive Regulation Of Lipase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Mesodermal Cell Differentiation Mesenchymal-epithelial Cell Signaling Positive Regulation Of MAPK Cascade Cementum Mineralization Fibroblast Growth Factor Receptor Activity Auditory Receptor Cell Development Paraxial Mesoderm Development Response To Sodium Phosphate Positive Regulation Of Nuclear Cell Cycle DNA Replication Regulation Of Phosphate Transport Forebrain Neuroblast Division Forebrain Ventricular Zone Progenitor Cell Division Salivary Gland Morphogenesis Branching Involved In Salivary Gland Morphogenesis Cell-cell Signaling Cell Communication Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Nuclear Cell Cycle DNA Replication Vitamin D Metabolic Process Inner Ear Receptor Cell Development Ear Development Regulation Of MAPK Cascade Signaling Positive Regulation Of Endothelial Cell Chemotaxis Positive Regulation Of DNA-templated DNA Replication Regulation Of Postsynaptic Density Assembly Middle Ear Morphogenesis Tooth Mineralization Positive Regulation Of Transport
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