FGF21

Description		fibroblast growth factor 21
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm
	Molecular Function	Fibroblast Growth Factor Receptor Binding Protein Binding Growth Factor Activity
	Biological Process	Signal Transduction Cell-cell Signaling Positive Regulation Of Cell Population Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Low-density Lipoprotein Particle Clearance Neurogenesis Regulation Of Cell Migration Positive Regulation Of MAPK Cascade Positive Regulation Of D-glucose Import Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of MAPKKK Cascade By Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Cold-induced Thermogenesis
Pathways		Cellular hexose transport Assembly of active LPL and LIPC lipase complexes
Drugs
Diseases
GWAS		Bipolar disorder ( 21926972) Breakfast cereal skipping frequency ( 31190057) Breakfast skipping ( 31190057) Cooked vegetable consumption ( 32066663) Dietary macronutrient intake ( 23372041 23636237 29988085) Fish- and plant-related diet ( 32066663) Fruit consumption ( 32066663) Meat-related diet ( 32066663) Non-oily fish consumption ( 32066663) Oily fish consumption ( 32066663) Pancreas volume ( 34128465) Pork consumption ( 32066663) Processed meat consumption ( 32066663) Relative carbohydrate intake ( 32393786) Relative protein intake ( 32393786) Relative sugar intake ( 32393786) Resting metabolic rate ( 28476931) Retinal vascular caliber ( 21060863) Triglyceride levels ( 32154731 32203549) Triglycerides ( 30275531) Urinary sodium excretion ( 31409800)
Interacting Genes		9 interacting genes: CDC25A CDH7 KLB MAPK7 NEDD4 SGTA SGTB TNS2 YPEL3
Entrez ID		26291
HPRD ID		09447
Ensembl ID		ENSG00000105550
Uniprot IDs		Q9NSA1
PDB IDs		5VAQ 6M6E 6M6F
Enriched GO Terms of Interacting Partners?		TRC Complex Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Protein Targeting Establishment Of Protein Localization To Endoplasmic Reticulum Protein Targeting To ER Establishment Of Protein Localization To Organelle Formation Of Structure Involved In A Symbiotic Process Protein Targeting To Membrane
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