TBKBP1 and CBX1

		TBKBP1	CBX1
Description		TBK1 binding protein 1	chromobox 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Serine/threonine Protein Kinase Complex	Chromosome, Centromeric Region Chromosome, Telomeric Region Chromatin Heterochromatin Female Pronucleus Male Pronucleus Nucleus Nucleoplasm Pericentric Heterochromatin Spindle Chromocenter Nuclear Body Site Of DNA Damage
	Molecular Function	Protein Binding Zinc Ion Binding Metal Ion Binding	Chromatin Binding Protein Binding Enzyme Binding Identical Protein Binding Histone Methyltransferase Binding
	Biological Process	Immune System Process Innate Immune Response Defense Response To Virus Type I Interferon-mediated Signaling Pathway	DNA Damage Response Heterochromatin Formation Negative Regulation Of DNA-templated Transcription
Pathways			HCMV Early Events
Drugs
Diseases
GWAS		Ankylosing spondylitis ( 21743469 23749187) Asthma ( 31619474) Asthma (childhood onset) ( 31036433) Body mass index ( 26426971 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index in physically inactive individuals ( 28448500) Human herpes virus 7 U14 antibody levels ( 33204752) Mean corpuscular hemoglobin ( 32888494) Multiple sclerosis ( 22190364) Very long-chain saturated fatty acid levels (fatty acid 20:0) ( 25378659)	Aspartate aminotransferase levels ( 33547301) Body mass index ( 20935630 26426971) Caffeine consumption from coffee ( 33287642) Caffeine consumption from coffee or tea ( 33287642) Generalized epilepsy ( 22949513)
Interacting Genes		6 interacting genes: AGO2 APBA3 CTNND2 IRAK1 KLHL2 TUBB	34 interacting genes: ABI3BP ARL5A ATXN7L2 BAHD1 BARD1 BRCA1 CBX3 CBX5 CHAF1A DNMT1 DNMT3A DNMT3B EMSY H1-4 H3-4 H3C1 H3C3 HECW2 HSPB1 KLF11 LNX1 LRIF1 NR2F6 PCNA PIM1 RPL12 SP100 SUV39H1 TRIM24 TRIM28 UCHL1 VHL VTN ZNF280C
Entrez ID		9755	10951
HPRD ID		12239	05149
Ensembl ID		ENSG00000198933	ENSG00000108468
Uniprot IDs		A7MCY6	P83916 Q6IBN6
PDB IDs			2FMM 3F2U 3Q6S 5T1G 6D07 6D08
Enriched GO Terms of Interacting Partners?			Chromatin Organization Heterochromatin Chromatin Remodeling Epigenetic Regulation Of Gene Expression Heterochromatin Formation Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process DNA (cytosine-5-)-methyltransferase Activity Nucleoplasm Chromatin Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Euchromatin Chromo Shadow Domain Binding Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Epigenetic Programming Of Gene Expression Negative Regulation Of Biosynthetic Process Ubiquitin-protein Transferase Activity Chromosome Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Chromosome, Telomeric Region Regulation Of Primary Metabolic Process DNA Damage Response Nucleosome Assembly Histone H2AK127 Ubiquitin Ligase Activity Nucleus Histone H2AK129 Ubiquitin Ligase Activity Regulation Of Macromolecule Metabolic Process BRCA1-BARD1 Complex Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Regulation Of Metabolic Process Nucleosome Organization DNA Binding Cellular Response To Stress DNA-methyltransferase Activity BRCA1-B Complex Cellular Response To Bisphenol A Structural Constituent Of Chromatin Pericentric Heterochromatin Post-translational Protein Modification Protein-DNA Complex Assembly
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