ADRA1A and GDE1

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		ADRA1A	GDE1
Description		adrenoceptor alpha 1A	glycerophosphodiester phosphodiesterase 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Caveola Membrane Nuclear Membrane	Plasma Membrane Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle
	Molecular Function	G Protein-coupled Receptor Activity Adrenergic Receptor Activity Alpha1-adrenergic Receptor Activity Protein Binding Protein Heterodimerization Activity	Phosphatidylcholine Lysophospholipase Activity Protein Binding Phosphoric Diester Hydrolase Activity Glycerophosphodiester Phosphodiesterase Activity Hydrolase Activity Metal Ion Binding Glycerophosphoinositol Glycerophosphodiesterase Activity
	Biological Process	MAPK Cascade Negative Regulation Of Heart Rate Involved In Baroreceptor Response To Increased Systemic Arterial Blood Pressure Norepinephrine-epinephrine Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure Positive Regulation Of Heart Rate By Epinephrine-norepinephrine Positive Regulation Of The Force Of Heart Contraction By Epinephrine-norepinephrine Apoptotic Process Regulation Of Muscle Contraction Smooth Muscle Contraction Signal Transduction G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Cell-cell Signaling Adult Heart Development Regulation Of Blood Pressure Negative Regulation Of Cell Population Proliferation Response To Xenobiotic Stimulus Response To Hormone Negative Regulation Of Autophagy Positive Regulation Of Cardiac Muscle Hypertrophy Regulation Of Vasoconstriction Positive Regulation Of Synaptic Transmission, GABAergic Organ Growth Intracellular Signal Transduction Positive Regulation Of MAPK Cascade Positive Regulation Of Action Potential Positive Regulation Of Vasoconstriction Positive Regulation Of Smooth Muscle Contraction Regulation Of Cardiac Muscle Contraction Positive Regulation Of Cardiac Muscle Contraction Cell Growth Involved In Cardiac Muscle Cell Development Positive Regulation Of ERK1 And ERK2 Cascade Adrenergic Receptor Signaling Pathway Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Phospholipase C-activating Adrenergic Receptor Signaling Pathway Pilomotor Reflex Neuron-glial Cell Signaling	Ethanolamine Metabolic Process Lipid Metabolic Process Phospholipid Metabolic Process Glycerophospholipid Catabolic Process N-acylethanolamine Metabolic Process
Pathways		Adrenoceptors G alpha (q) signalling events G alpha (12/13) signalling events	Glycerophospholipid catabolism
Drugs		Amphetamine Midodrine Ranolazine Ziprasidone Cabergoline Ropinirole Dapiprazole Dihydroergotamine Amitriptyline Olanzapine Alfuzosin Alfuzosin Clozapine Norepinephrine Mirtazapine Phenylephrine Loxapine Promazine Prochlorperazine Dipivefrin Droperidol Prazosin Prazosin Imipramine Chlorpromazine Chlorpromazine Buspirone Haloperidol Nortriptyline Amoxapine Amoxapine Lamotrigine Clonidine Doxazosin Labetalol Metaraminol Nicardipine Trazodone Verapamil Epinephrine Thioridazine Phentolamine Ergotamine Tizanidine Nicergoline Tamsulosin Paroxetine Methoxamine Trimipramine Risperidone Epinastine Propiomazine Tolazoline Fenoldopam Trifluoperazine Dobutamine Pseudoephedrine Benzphetamine Flupentixol Quinidine Phenoxybenzamine Maprotiline Oxymetazoline Apraclonidine Ergoloid mesylate Promethazine Carvedilol Carvedilol Doxepin Nefazodone Desipramine Terazosin Escitalopram Pergolide Bromocriptine Quetiapine Aripiprazole Ergometrine Paliperidone Bevantolol Ephedrine Mephentermine Methotrimeprazine 4-Methoxyamphetamine Dextroamphetamine Phendimetrazine Acepromazine Thioproperazine Zuclopenthixol Dronedarone Iloperidone Lofexidine R450 Epicept NP-1 Cariprazine Sertindole Mianserin Pizotifen Silodosin Asenapine Ocaperidone Droxidopa Xylometazoline Isometheptene Naphazoline Tetryzoline Perospirone Indoramin Dosulepin Etoperidone Lorpiprazole Cirazoline Synephrine Arotinolol Moxisylyte Aranidipine Niguldipine Pipamperone Racepinephrine Dihydroergocornine DL-Methylephedrine Indigotindisulfonic acid Propiverine Tiapride Dihydroergocristine Aripiprazole lauroxil
Diseases
GWAS		Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Response to amphetamines ( 22952603) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858)
Interacting Genes		30 interacting genes: ABR ADGRA3 ADRA1B ADRA1D ANO8 ATP6AP2 BMP1 CD81 CXCR1 CXCR2 FAM241B FAM50B FLNC GDE1 GPR37 HHATL KIAA2013 KLHL22 MBOAT7 NOS1 NTNG2 PPP1R9B RGS2 SCN1B SGCB TBC1D20 TMEM234 TPCN2 UBR4 UGT8	7 interacting genes: ADRA1A CLGN RGS1 RGS16 RGS19 RGS2 SLC10A1
Entrez ID		148	51573
HPRD ID		00081	12070
Ensembl ID		ENSG00000120907	ENSG00000006007
Uniprot IDs		B0ZBD3 P35348	Q9NZC3
PDB IDs		7YM8 7YMH 7YMJ 8HN1 8THK 8THL
Enriched GO Terms of Interacting Partners?		Membrane Interleukin-8-mediated Signaling Pathway Interleukin-8 Receptor Activity Alpha1-adrenergic Receptor Activity Calcium-mediated Signaling Interleukin-8 Binding Neuron-glial Cell Signaling G Protein-coupled Receptor Activity Regulation Of Blood Circulation C-X-C Chemokine Receptor Activity Adrenergic Receptor Activity Plasma Membrane Positive Regulation Of Cytosolic Calcium Ion Concentration Receptor-mediated Endocytosis Dendritic Spine Membrane Receptor Internalization Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Regulation Of Heart Contraction Regulation Of Cardiac Muscle Contraction Dendritic Cell Chemotaxis Positive Regulation Of Sodium Ion Transmembrane Transport Intracellular Signaling Cassette Adrenergic Receptor Signaling Pathway Regulation Of Striated Muscle Contraction Intercellular Bridge Chemokine Receptor Activity C-C Chemokine Binding C-C Chemokine Receptor Activity Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Response To Immobilization Stress Dendritic Cell Migration Regulation Of MAPK Cascade Sarcolemma Muscle System Process Myoblast Fusion Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Macrophage Fusion Cell-cell Fusion Positive Regulation Of Adaptive Immune Memory Response CD4-positive, Alpha-beta T Cell Costimulation Syncytium Formation By Plasma Membrane Fusion Transmembrane Transporter Binding Sodium Channel Regulator Activity Regulation Of Membrane Repolarization Positive Regulation Of Sodium Ion Transport Response To Amphetamine Regulation Of Adenylate Cyclase-inhibiting Adrenergic Receptor Signaling Pathway Corticospinal Neuron Axon Guidance N-acylsphingosine Galactosyltransferase Activity	G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cardiac Muscle Contraction GTPase Activity Positive Regulation Of Striated Muscle Contraction G-protein Alpha-subunit Binding Calmodulin Binding Positive Regulation Of Heart Contraction GTPase Activator Activity Positive Regulation Of Muscle Contraction Regulation Of Smooth Muscle Contraction Negative Regulation Of Heart Rate Involved In Baroreceptor Response To Increased Systemic Arterial Blood Pressure Regulation Of Cardiac Muscle Hypertrophy Regulation Of Adenylate Cyclase-inhibiting Adrenergic Receptor Signaling Pathway Regulation Of Cardiac Muscle Contraction Positive Regulation Of GTPase Activity Positive Regulation Of The Force Of Heart Contraction By Epinephrine-norepinephrine Positive Regulation Of Heart Rate By Epinephrine-norepinephrine Phospholipase C-activating Adrenergic Receptor Signaling Pathway Norepinephrine-epinephrine Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure Regulation Of Striated Muscle Contraction Cytoplasmic Side Of Plasma Membrane Negative Regulation Of Glycine Import Across Plasma Membrane Positive Regulation Of Hydrolase Activity Response To Ethanol Pilomotor Reflex Alpha1-adrenergic Receptor Activity Positive Regulation Of The Force Of Heart Contraction By Chemical Signal Negative Regulation Of Signal Transduction Regulation Of GTPase Activity Membrane Leukotriene Signaling Pathway Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase Inhibitor Activity Plasma Membrane Regulation Of Muscle Contraction Neuron-glial Cell Signaling Bile Acid:sodium Symporter Activity Regulation Of The Force Of Heart Contraction By Chemical Signal Relaxation Of Vascular Associated Smooth Muscle Regulation Of Signal Transduction Regulation Of Heart Contraction Positive Regulation Of Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Relaxation Of Smooth Muscle Cell Growth Involved In Cardiac Muscle Cell Development Positive Regulation Of Action Potential Adrenergic Receptor Activity Bile Acid Transmembrane Transporter Activity Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway
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