ADRA1A and SCN1B

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		ADRA1A	SCN1B
Description		adrenoceptor alpha 1A	sodium voltage-gated channel beta subunit 1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Caveola Membrane Nuclear Membrane	Voltage-gated Sodium Channel Complex Extracellular Region Plasma Membrane Intercalated Disc Membrane T-tubule Axon Node Of Ranvier Sodium Channel Complex Cell Projection Perikaryon
	Molecular Function	G Protein-coupled Receptor Activity Adrenergic Receptor Activity Alpha1-adrenergic Receptor Activity Protein Binding Protein Heterodimerization Activity	Protein Binding Sodium Channel Regulator Activity Sodium Channel Inhibitor Activity Transmembrane Transporter Binding
	Biological Process	MAPK Cascade Negative Regulation Of Heart Rate Involved In Baroreceptor Response To Increased Systemic Arterial Blood Pressure Norepinephrine-epinephrine Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure Positive Regulation Of Heart Rate By Epinephrine-norepinephrine Positive Regulation Of The Force Of Heart Contraction By Epinephrine-norepinephrine Apoptotic Process Regulation Of Muscle Contraction Smooth Muscle Contraction Signal Transduction G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Cell-cell Signaling Adult Heart Development Regulation Of Blood Pressure Negative Regulation Of Cell Population Proliferation Response To Xenobiotic Stimulus Response To Hormone Negative Regulation Of Autophagy Positive Regulation Of Cardiac Muscle Hypertrophy Regulation Of Vasoconstriction Positive Regulation Of Synaptic Transmission, GABAergic Organ Growth Intracellular Signal Transduction Positive Regulation Of MAPK Cascade Positive Regulation Of Action Potential Positive Regulation Of Vasoconstriction Positive Regulation Of Smooth Muscle Contraction Regulation Of Cardiac Muscle Contraction Positive Regulation Of Cardiac Muscle Contraction Cell Growth Involved In Cardiac Muscle Cell Development Positive Regulation Of ERK1 And ERK2 Cascade Adrenergic Receptor Signaling Pathway Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Phospholipase C-activating Adrenergic Receptor Signaling Pathway Pilomotor Reflex Neuron-glial Cell Signaling	Regulation Of Sodium Ion Transport Monoatomic Ion Transport Sodium Ion Transport Cell Adhesion Axon Guidance Positive Regulation Of Sodium Ion Transport Positive Regulation Of Neuron Projection Development Neuronal Action Potential Propagation Corticospinal Neuron Axon Guidance Neuron Projection Development Sodium Ion Transmembrane Transport Locomotion Membrane Depolarization Cardiac Muscle Contraction Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Regulation Of Atrial Cardiac Muscle Cell Membrane Depolarization Cardiac Conduction Cardiac Muscle Cell Action Potential Involved In Contraction Membrane Depolarization During Action Potential Membrane Depolarization During Cardiac Muscle Cell Action Potential Membrane Depolarization During Purkinje Myocyte Cell Action Potential Regulation Of Heart Rate By Cardiac Conduction Regulation Of Sodium Ion Transmembrane Transport Positive Regulation Of Voltage-gated Sodium Channel Activity
Pathways		Adrenoceptors G alpha (q) signalling events G alpha (12/13) signalling events	Interaction between L1 and Ankyrins Phase 0 - rapid depolarisation Sensory perception of sweet, bitter, and umami (glutamate) taste
Drugs		Amphetamine Midodrine Ranolazine Ziprasidone Cabergoline Ropinirole Dapiprazole Dihydroergotamine Amitriptyline Olanzapine Alfuzosin Alfuzosin Clozapine Norepinephrine Mirtazapine Phenylephrine Loxapine Promazine Prochlorperazine Dipivefrin Droperidol Prazosin Prazosin Imipramine Chlorpromazine Chlorpromazine Buspirone Haloperidol Nortriptyline Amoxapine Amoxapine Lamotrigine Clonidine Doxazosin Labetalol Metaraminol Nicardipine Trazodone Verapamil Epinephrine Thioridazine Phentolamine Ergotamine Tizanidine Nicergoline Tamsulosin Paroxetine Methoxamine Trimipramine Risperidone Epinastine Propiomazine Tolazoline Fenoldopam Trifluoperazine Dobutamine Pseudoephedrine Benzphetamine Flupentixol Quinidine Phenoxybenzamine Maprotiline Oxymetazoline Apraclonidine Ergoloid mesylate Promethazine Carvedilol Carvedilol Doxepin Nefazodone Desipramine Terazosin Escitalopram Pergolide Bromocriptine Quetiapine Aripiprazole Ergometrine Paliperidone Bevantolol Ephedrine Mephentermine Methotrimeprazine 4-Methoxyamphetamine Dextroamphetamine Phendimetrazine Acepromazine Thioproperazine Zuclopenthixol Dronedarone Iloperidone Lofexidine R450 Epicept NP-1 Cariprazine Sertindole Mianserin Pizotifen Silodosin Asenapine Ocaperidone Droxidopa Xylometazoline Isometheptene Naphazoline Tetryzoline Perospirone Indoramin Dosulepin Etoperidone Lorpiprazole Cirazoline Synephrine Arotinolol Moxisylyte Aranidipine Niguldipine Pipamperone Racepinephrine Dihydroergocornine DL-Methylephedrine Indigotindisulfonic acid Propiverine Tiapride Dihydroergocristine Aripiprazole lauroxil	Ranolazine Phenytoin Valproic acid Oxcarbazepine Cocaine Zonisamide Brivaracetam Dichlorobenzyl alcohol Fish oil
Diseases			Febrile seizures, including: Febrile convulsions; Generalized epilepsy with febrile seizure plus (GEFS+); Dravet syndrome/ Severe myoclonic epilepsy in infancy (SMEI) Brugada syndrome (BRS)
GWAS		Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Response to amphetamines ( 22952603) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858)	Metabolite levels ( 23823483) Serum albumin levels ( 23022100)
Interacting Genes		30 interacting genes: ABR ADGRA3 ADRA1B ADRA1D ANO8 ATP6AP2 BMP1 CD81 CXCR1 CXCR2 FAM241B FAM50B FLNC GDE1 GPR37 HHATL KIAA2013 KLHL22 MBOAT7 NOS1 NTNG2 PPP1R9B RGS2 SCN1B SGCB TBC1D20 TMEM234 TPCN2 UBR4 UGT8	6 interacting genes: ADRA1A ANK3 C5AR2 F2RL1 NFASC SCN2B
Entrez ID		148	6324
HPRD ID		00081	02581
Ensembl ID		ENSG00000120907	ENSG00000105711
Uniprot IDs		B0ZBD3 P35348	A0A1W2PR05 Q07699
PDB IDs		7YM8 7YMH 7YMJ 8HN1 8THK 8THL	6AGF 6J8G 6J8H 6J8I 6J8J 7W77 7W7F 7W9K 7W9L 7W9M 7W9P 7W9T 7XM9 7XMF 7XMG 7XVE 7XVF 8FHD 8G1A 8GZ1 8GZ2 8I5B 8I5G 8I5X 8I5Y 8J4F 8S9B 8S9C 8THG 8THH 8XMM 8XMN 8XMO
Enriched GO Terms of Interacting Partners?		Membrane Interleukin-8-mediated Signaling Pathway Interleukin-8 Receptor Activity Alpha1-adrenergic Receptor Activity Calcium-mediated Signaling Interleukin-8 Binding Neuron-glial Cell Signaling G Protein-coupled Receptor Activity Regulation Of Blood Circulation C-X-C Chemokine Receptor Activity Adrenergic Receptor Activity Plasma Membrane Positive Regulation Of Cytosolic Calcium Ion Concentration Receptor-mediated Endocytosis Dendritic Spine Membrane Receptor Internalization Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Regulation Of Heart Contraction Regulation Of Cardiac Muscle Contraction Dendritic Cell Chemotaxis Positive Regulation Of Sodium Ion Transmembrane Transport Intracellular Signaling Cassette Adrenergic Receptor Signaling Pathway Regulation Of Striated Muscle Contraction Intercellular Bridge Chemokine Receptor Activity C-C Chemokine Binding C-C Chemokine Receptor Activity Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Response To Immobilization Stress Dendritic Cell Migration Regulation Of MAPK Cascade Sarcolemma Muscle System Process Myoblast Fusion Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Macrophage Fusion Cell-cell Fusion Positive Regulation Of Adaptive Immune Memory Response CD4-positive, Alpha-beta T Cell Costimulation Syncytium Formation By Plasma Membrane Fusion Transmembrane Transporter Binding Sodium Channel Regulator Activity Regulation Of Membrane Repolarization Positive Regulation Of Sodium Ion Transport Response To Amphetamine Regulation Of Adenylate Cyclase-inhibiting Adrenergic Receptor Signaling Pathway Corticospinal Neuron Axon Guidance N-acylsphingosine Galactosyltransferase Activity	Node Of Ranvier Axon Initial Segment Positive Regulation Of Cytosolic Calcium Ion Concentration Sodium Channel Regulator Activity Positive Regulation Of Sodium Ion Transport T-tubule Regulation Of Membrane Depolarization Negative Regulation Of Heart Rate Involved In Baroreceptor Response To Increased Systemic Arterial Blood Pressure G Protein-coupled Receptor Activity Regulation Of Membrane Potential Plasma Membrane Axon Basal Plasma Membrane Regulation Of Sodium Ion Transport Positive Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium Positive Regulation Of Renin Secretion Into Blood Stream Response To Pyrethroid Positive Regulation Of The Force Of Heart Contraction By Epinephrine-norepinephrine Positive Regulation Of Heart Rate By Epinephrine-norepinephrine Regulation Of Biological Quality Phospholipase C-activating Adrenergic Receptor Signaling Pathway Regulation Of System Process Norepinephrine-epinephrine Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure Regulation Of Heart Rate Positive Regulation Of Membrane Depolarization During Cardiac Muscle Cell Action Potential Action Potential Maintenance Of Protein Location In Plasma Membrane Proteinase-activated Receptor Activity Regulation Of Interleukin-8 Production Positive Regulation Of Eosinophil Degranulation Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Pilomotor Reflex Alpha1-adrenergic Receptor Activity Positive Regulation Of The Force Of Heart Contraction By Chemical Signal Positive Regulation Of Cell Communication By Electrical Coupling Positive Regulation Of Glomerular Filtration Regulation Of Renin Secretion Into Blood Stream Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Complement Component C5a Receptor Activity Blood Vessel Diameter Maintenance Regulation Of Tube Size Regulation Of Interleukin-6 Production Positive Regulation Of Killing Of Cells Of Another Organism Voltage-gated Sodium Channel Activity Involved In Cardiac Muscle Cell Action Potential Complement Component C5a Signaling Pathway Regulation Of Blood Pressure G Protein-coupled Receptor Signaling Pathway Neuron-glial Cell Signaling Positive Regulation Of ERK1 And ERK2 Cascade
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