SDHAF4 and UPK1B

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SDHAF4	UPK1B
Description		succinate dehydrogenase complex assembly factor 4	uroplakin 1B
Image			No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix	Membrane Apical Plasma Membrane Extracellular Exosome Apical Plasma Membrane Urothelial Plaque
	Molecular Function	Protein Binding Enzyme Activator Activity Protein Folding Chaperone	Structural Molecule Activity Protein Binding
	Biological Process	Tricarboxylic Acid Cycle Protein Folding Mitochondrial Respiratory Chain Complex II Assembly Innate Immune Response Cellular Respiration	Response To Bacterium Epithelial Cell Differentiation
Pathways		Maturation of TCA enzymes and regulation of TCA cycle
Drugs
Diseases
GWAS			Gemcitabine-induced early high-grade neutropenia in pancreatic cancer ( 30889042)
Interacting Genes		3 interacting genes: CD81 CYB5B UPK1B	59 interacting genes: BCL2L13 BEST2 BIK BNIP2 CATSPERH CD53 CD69 CD79A CERS4 CLDN7 CYB5R3 DAGLA EDAR ERGIC3 FAM209A FFAR2 FKBP7 FNDC9 GJA8 GJB1 GPR161 GPR37L1 GPX8 ISLR2 ITGB2 KASH5 KCNJ6 KIR2DL3 KLRC1 LMNA MFF MS4A4A NEMP1 PDZK1IP1 PIK3IP1 PLPP4 RHCG SAR1A SDHAF4 SHISA4 SIT1 SLC10A1 SLC10A2 SLC16A2 SLC18A1 SLC35H1 SLC39A2 SPINT1 SSMEM1 STX1A SYT9 TMEM139 TMEM237 TMEM45B TMEM54 TMEM91 TMUB2 UPK3A VSIG1
Entrez ID		135154	7348
HPRD ID		12888	03853
Ensembl ID		ENSG00000154079	ENSG00000114638
Uniprot IDs		Q5VUM1	O75841
PDB IDs		8DYD 8DYE
Enriched GO Terms of Interacting Partners?		Macrophage Fusion Positive Regulation Of Adaptive Immune Memory Response CD4-positive, Alpha-beta T Cell Costimulation Positive Regulation Of T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Myoblast Fusion Involved In Skeletal Muscle Regeneration Apical Plasma Membrane Urothelial Plaque Nitric-oxide Synthase Complex MHC Class II Protein Binding Humoral Immune Response Mediated By Circulating Immunoglobulin Osteoclast Fusion Nitrite Reductase (NO-forming) Activity Positive Regulation Of Protein Catabolic Process In The Vacuole Positive Regulation Of T-helper 2 Cell Cytokine Production Positive Regulation Of B Cell Receptor Signaling Pathway Positive Regulation Of CD4-positive, Alpha-beta T Cell Proliferation Tetraspanin-enriched Microdomain Positive Regulation Of Protein Exit From Endoplasmic Reticulum Transferrin Receptor Binding Positive Regulation Of Receptor Clustering Positive Regulation Of Inflammatory Response To Antigenic Stimulus Immunological Synapse Formation Regulation Of Receptor Clustering Positive Regulation Of Type 2 Immune Response Positive Regulation Of T Cell Receptor Signaling Pathway Regulation Of CD4-positive, Alpha-beta T Cell Proliferation Regulation Of Protein Exit From Endoplasmic Reticulum Nitric Oxide Biosynthetic Process Regulation Of B Cell Receptor Signaling Pathway Positive Regulation Of Alpha-beta T Cell Proliferation MHC Class II Protein Complex Binding Positive Regulation Of Antigen Receptor-mediated Signaling Pathway Myoblast Fusion Positive Regulation Of T Cell Cytokine Production Cellular Response To Low-density Lipoprotein Particle Stimulus Nitric Oxide Metabolic Process Reactive Nitrogen Species Metabolic Process Regulation Of Type 2 Immune Response Cell-cell Fusion Syncytium Formation By Plasma Membrane Fusion Cellular Response To Lipoprotein Particle Stimulus Syncytium Formation Immunoglobulin Mediated Immune Response Regulation Of T Cell Cytokine Production T Cell Costimulation B Cell Mediated Immunity Immunological Synapse Positive Regulation Of B Cell Proliferation Regulation Of Macrophage Migration Positive Regulation Of CD4-positive, Alpha-beta T Cell Activation Cholesterol Binding	Membrane Protein Binding Plasma Membrane Bile Acid:sodium Symporter Activity
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