TACR1

Description		tachykinin receptor 1
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GO Annotations	Cellular Component	Plasma Membrane Cell Surface Membrane Dendrite Sperm Flagellum Cell Body Postsynaptic Membrane Sperm Head Cell Periphery Sperm Midpiece
	Molecular Function	G Protein-coupled Receptor Activity Tachykinin Receptor Activity Protein Binding Substance P Receptor Activity
	Biological Process	Aggressive Behavior Positive Regulation Of Leukocyte Migration Angiotensin-mediated Drinking Behavior Inflammatory Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Tachykinin Receptor Signaling Pathway Learning Or Memory Long-term Memory Regulation Of Blood Pressure Associative Learning Detection Of Abiotic Stimulus Response To Hormone Response To Ozone Positive Regulation Of Epithelial Cell Migration Response To Auditory Stimulus Regulation Of Smooth Muscle Cell Migration Positive Regulation Of Synaptic Transmission, Cholinergic Positive Regulation Of Synaptic Transmission, GABAergic Response To Estradiol Response To Progesterone Response To Nicotine Operant Conditioning Sperm Ejaculation Eating Behavior Positive Regulation Of Vascular Permeability Response To Ethanol Positive Regulation Of Action Potential Positive Regulation Of Blood Pressure Positive Regulation Of Ossification Positive Regulation Of Vasoconstriction Positive Regulation Of Hormone Secretion Response To Pain Behavioral Response To Pain Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Stress Fiber Assembly Response To Electrical Stimulus Smooth Muscle Contraction Involved In Micturition Regulation Of Uterine Smooth Muscle Contraction Positive Regulation Of Uterine Smooth Muscle Contraction Positive Regulation Of Flagellated Sperm Motility
Pathways		Tachykinin receptors bind tachykinins G alpha (q) signalling events Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs		Tramadol Aprepitant Ketamine Vapreotide AV608 GW 597599 CP-122721 R673 SR 140333 Casopitant Netupitant Rolapitant Vestipitant Vofopitant Fosnetupitant
Diseases
GWAS		Bipolar disorder x sex interaction ( 34099189) Brain connectivity ( 23471985) Chronotype ( 30696823) Diisocyanate-induced asthma ( 25918132) Gout ( 32238385) Nonunion in individuals with fractures ( 30680360) Pursuit maintenance gain ( 29064472) Seborrheic dermatitis ( 29203360) Sexual dimorphism in anthropometric traits ( 23754948) Weight ( 28552196)
Interacting Genes		7 interacting genes: CCDC167 GPRASP1 GRK5 TAC1 TAC3 TAC4 TMEM147
Entrez ID		6869
HPRD ID		01208
Ensembl ID		ENSG00000115353
Uniprot IDs		P25103
PDB IDs		2KS9 2KSA 2KSB 6E59 6HLL 6HLO 6HLP 7P00 7P02 7RMG 7RMH 7RMI 8U26
Enriched GO Terms of Interacting Partners?		Tachykinin Receptor Signaling Pathway Substance K Receptor Binding Positive Regulation Of Flagellated Sperm Motility Positive Regulation Of Cilium Movement Regulation Of Flagellated Sperm Motility Substance P Receptor Binding Neuromedin K Receptor Binding Regulation Of Cilium Movement Positive Regulation Of Sensory Perception Of Pain Regulation Of Microtubule-based Movement Positive Regulation Of Reproductive Process Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Regulation Of Sensory Perception Of Pain Detection Of Temperature Stimulus Involved In Sensory Perception Regulation Of Blood Pressure Negative Regulation Of Systemic Arterial Blood Pressure Detection Of Temperature Stimulus Regulation Of Reproductive Process Regulation Of Microtubule-based Process G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Blood Pressure Neuropeptide Signaling Pathway G Protein-coupled Receptor Catabolic Process Regulation Of Nervous System Process Detection Of Abiotic Stimulus Receptor Ligand Activity Positive Regulation Of Cell Motility Positive Regulation Of Corticosterone Secretion Protein Localization To Nuclear Inner Membrane Negative Regulation Of Sensory Perception Of Pain Positive Regulation Of Locomotion Detection Of Stimulus Involved In Sensory Perception Beta-adrenergic Receptor Kinase Activity Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Insemination Response To Temperature Stimulus Regulation Of Corticosterone Secretion G Protein-coupled Receptor Kinase Activity Positive Regulation Of Synaptic Transmission, Cholinergic Positive Regulation Of Action Potential Multi-pass Transmembrane Protein Insertion Into ER Membrane Multi-pass Translocon Complex Detection Of Stimulus Antifungal Humoral Response Nuclear Membrane Negative Regulation Of Heart Rate Protein Localization To Nuclear Envelope Response To Yeast Regulation Of Cell Motility
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