TACR1 and TAC3

Number of citations of the paper that reports this interaction (PMID 12727971)
3

Data Source:
HPRD (in vitro)

		TACR1	TAC3
Gene Name		tachykinin receptor 1	tachykinin 3
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Dendrite Cell Body	Extracellular Region Extracellular Space Extracellular Vesicular Exosome
	Molecular Function	Tachykinin Receptor Activity Protein Binding Substance P Receptor Activity	Receptor Binding Protein Binding
	Biological Process	Aggressive Behavior Acute Inflammatory Response Positive Regulation Of Leukocyte Migration Angiotensin-mediated Drinking Behavior Inflammatory Response Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Tachykinin Receptor Signaling Pathway Long-term Memory Associative Learning Response To Heat Detection Of Abiotic Stimulus Response To Ozone Positive Regulation Of Epithelial Cell Migration Response To Auditory Stimulus Regulation Of Smooth Muscle Cell Migration Positive Regulation Of Synaptic Transmission, Cholinergic Positive Regulation Of Synaptic Transmission, GABAergic Response To Estradiol Response To Progesterone Response To Nicotine Operant Conditioning Positive Regulation Of Renal Sodium Excretion Sperm Ejaculation Eating Behavior Positive Regulation Of Vascular Permeability Response To Morphine Response To Ethanol Positive Regulation Of Action Potential Positive Regulation Of Blood Pressure Positive Regulation Of Ossification Positive Regulation Of Vasoconstriction Positive Regulation Of Saliva Secretion Positive Regulation Of Hormone Secretion Behavioral Response To Pain Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Stress Fiber Assembly Response To Electrical Stimulus Smooth Muscle Contraction Involved In Micturition Positive Regulation Of Uterine Smooth Muscle Contraction	Tachykinin Receptor Signaling Pathway Neuropeptide Signaling Pathway Female Pregnancy
Pathways		G alpha (q) signalling events G alpha (q) signalling events Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Tachykinin receptors bind tachykinins Gastrin-CREB signalling pathway via PKC and MAPK Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding	G alpha (q) signalling events G alpha (q) signalling events Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Tachykinin receptors bind tachykinins Gastrin-CREB signalling pathway via PKC and MAPK Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs		Aprepitant Ketamine Vapreotide
Diseases
GWAS		Brain connectivity ( 23471985)
Protein-Protein Interactions		5 interactors: GPRASP1 GRK5 TAC1 TAC3 TAC4	10 interactors: CCDC90B FEZ1 GPRASP1 IKBKAP PTN TACR1 TACR2 TACR3 UBC UBR1
Entrez ID		6869	6866
HPRD ID		01208	08877
Ensembl ID		ENSG00000115353	ENSG00000166863
Uniprot IDs		P25103	Q9UHF0
PDB IDs		2KS9 2KSA 2KSB	1P9F
Enriched GO Terms of Interacting Partners?		Tachykinin Receptor Signaling Pathway Positive Regulation Of Saliva Secretion Regulation Of Saliva Secretion Positive Regulation Of Digestive System Process G-protein Coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway G-protein Coupled Receptor Catabolic Process Positive Regulation Of Corticosterone Secretion Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of Blood Pressure Positive Regulation Of Synaptic Transmission, Cholinergic Regulation Of Corticosterone Secretion Regulation Of Synaptic Transmission, Cholinergic Cell Surface Receptor Signaling Pathway Blood Circulation Positive Regulation Of Secretion Positive Regulation Of Action Potential Negative Regulation Of Heart Rate Positive Regulation Of Renal Sodium Excretion Positive Regulation Of Synaptic Transmission, GABAergic Insemination Receptor Catabolic Process Regulation Of Renal Sodium Excretion Copulation Negative Regulation Of Heart Contraction Regulation Of Excretion Positive Regulation Of Acute Inflammatory Response Endosome To Lysosome Transport Regulation Of Secretion Regulation Of Synaptic Transmission, GABAergic Response To Pain Response To Morphine Positive Regulation Of Transport Positive Regulation Of Stress Fiber Assembly Lysosomal Transport Long-term Memory Signal Transduction Positive Regulation Of Actin Filament Bundle Assembly Mating Positive Regulation Of Lipid Transport Signaling Regulation Of Stress Fiber Assembly Termination Of G-protein Coupled Receptor Signaling Pathway Cell Communication Termination Of Signal Transduction Regulation Of Acute Inflammatory Response Regulation Of Heart Rate	Tachykinin Receptor Signaling Pathway Positive Regulation Of Uterine Smooth Muscle Contraction Positive Regulation Of Smooth Muscle Contraction Regulation Of Smooth Muscle Contraction Operant Conditioning Neuropeptide Signaling Pathway Positive Regulation Of Vascular Permeability Learning Regulation Of Muscle Contraction Regulation Of Vascular Permeability Positive Regulation Of Blood Pressure Response To Morphine Learning Or Memory Response To Electrical Stimulus Excretion Cognition Blood Circulation Smooth Muscle Contraction Cellular Response To Stimulus Positive Regulation Of Acetylcholine Secretion, Neurotransmission Response To Abiotic Stimulus Single-organism Behavior Response To Ammonium Ion Negative Regulation Of Signaling Cellular Response To Leucine G-protein Coupled Receptor Catabolic Process Positive Regulation Of Synaptic Transmission Response To Estradiol Intestine Smooth Muscle Contraction Negative Regulation Of Luteinizing Hormone Secretion Angiotensin-mediated Drinking Behavior Smooth Muscle Contraction Involved In Micturition Synaptic Transmission Behavior Response To Organic Substance Response To Stimulus Response To Alkaloid Regulation Of Acetylcholine Secretion, Neurotransmission Positive Regulation Of Synaptic Transmission, Cholinergic Positive Regulation Of Saliva Secretion Regulation Of Blood Pressure Regulation Of Cellular Process Prolactin Secretion Negative Regulation Of Gonadotropin Secretion Regulation Of Synaptic Transmission, Cholinergic Response To Leucine Regulation Of Saliva Secretion Micturition Response To Ozone Endosomal Transport
Tagcloud ?			bioinformatics cichlids dispersed fsh fxglm gonadotropin holds isoleucine lh luc neurokinin nh2 nkb nkbs nkf piscine pituitary possess possessing reproduction sre tac3r tac3ra tac3rb tachikinin tilapia tinkb tinkf valine
Tagcloud (Difference) ?			bioinformatics cichlids dispersed fsh fxglm gonadotropin holds isoleucine lh luc neurokinin nh2 nkb nkbs nkf piscine pituitary possess possessing reproduction sre tac3r tac3ra tac3rb tachikinin tilapia tinkb tinkf valine
Tagcloud (Intersection) ?