OPRD1 and CTXN3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		OPRD1	CTXN3
Description		opioid receptor delta 1	cortexin 3
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Synaptic Vesicle Membrane Vesicle Dendrite Membrane Presynaptic Membrane Neuron Projection Axon Terminus Postsynaptic Membrane Spine Apparatus Postsynaptic Density Membrane Neuronal Dense Core Vesicle	Membrane
	Molecular Function	G Protein-coupled Receptor Activity G Protein-coupled Opioid Receptor Activity Protein Binding G Protein-coupled Peptide Receptor Activity Receptor Serine/threonine Kinase Binding G Protein-coupled Enkephalin Receptor Activity Neuropeptide Binding	Protein Binding
	Biological Process	Immune Response Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Adult Locomotory Behavior Negative Regulation Of Gene Expression Negative Regulation Of Protein-containing Complex Assembly Response To Nicotine G Protein-coupled Opioid Receptor Signaling Pathway Eating Behavior Response To Ethanol Regulation Of Mitochondrial Membrane Potential Regulation Of Calcium Ion Transport Cellular Response To Growth Factor Stimulus Cellular Response To Hypoxia Cellular Response To Toxic Substance
Pathways		Peptide ligand-binding receptors G alpha (i) signalling events Interleukin-4 and Interleukin-13 signaling
Drugs		Tramadol Morphine Codeine Amitriptyline Hydromorphone Methadone Oxycodone Dextromethorphan Butorphanol Dextropropoxyphene Naltrexone Sufentanil Fentanyl Loperamide Nalbuphine Levorphanol Remifentanil Buprenorphine Hydrocodone Diphenoxylate Naloxone Oxymorphone Ketamine Aripiprazole 3-Methylthiofentanyl Dimethylthiambutene Diamorphine Etorphine Carfentanil Diprenorphine Dihydromorphine 3-Methylfentanyl ADL5859 Tapentadol Nalmefene Alvimopan Amisulpride Morphine glucuronide Ketobemidone Cannabidiol Butyrfentanyl Pholcodine Eluxadoline Opium Naldemedine Samidorphan Metenkefalin Medical Cannabis Nabiximols Loxicodegol
Diseases
GWAS		Tourette syndrome ( 30818990)	Brain imaging in schizophrenia (dorsolateral prefrontal cortex interaction) ( 19023125) Plasma amyloid beta peptide concentrations (ABx-42) ( 24535457)
Interacting Genes		22 interacting genes: ADRB2 ARRB1 ARRB2 CTXN3 GNA15 GNAI1 GNAI2 GNAO1 GNAZ GPRASP1 GRK2 KLHL3 OPRK1 OPRM1 PRKCA PRKCD PRKCE RPRM SLC12A7 SLC13A4 SMAGP TMEM237	59 interacting genes: ADGRG3 AQP6 AQP9 ATP1B3 BIK BTN2A1 CD300E CD53 CD79A CERS4 CLDN14 CLEC17A CLEC7A CLRN1 COQ9 CPLX4 CREB3L1 CTLA4 EDA ERGIC3 FAM209A FFAR3 FUT7 GJA8 GJB1 GJB5 GPR152 GPR42 GPR61 IFNLR1 KASH5 KIR3DL3 KLRC1 LAPTM4B LDLRAD1 LHFPL5 LSMEM2 MFF MGST2 MTIF3 NCAPH2 OPRD1 OPRM1 PACC1 PLPP5 PVR SCN3B SLC10A2 SPACA1 STOM TLCD4 TM4SF19 TMEM106C TMEM167B TMEM179B TMEM31 TMPRSS2 TMX2 TSPAN12
Entrez ID		4985	613212
HPRD ID		01308	18888
Ensembl ID		ENSG00000116329	ENSG00000205279
Uniprot IDs		P41143	Q4LDR2
PDB IDs		4N6H 4RWA 4RWD 6PT2 6PT3 8F7S 8Y45
Enriched GO Terms of Interacting Partners?		G Protein-coupled Receptor Binding Guanyl Nucleotide Binding Negative Regulation Of G Protein-coupled Receptor Signaling Pathway G-protein Beta/gamma-subunit Complex Binding Heterotrimeric G-protein Complex Regulation Of G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway G Protein-coupled Serotonin Receptor Binding Postsynaptic Signal Transduction Regulation Of Transport Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway G Protein-coupled Acetylcholine Receptor Signaling Pathway Regulation Of Secretion By Cell Negative Regulation Of Secretion By Cell Desensitization Of G Protein-coupled Receptor Signaling Pathway Regulation Of Secretion Positive Regulation Of MAPK Cascade Negative Regulation Of Cell Communication Regulation Of MAPK Cascade Negative Regulation Of Signaling Negative Adaptation Of Signaling Pathway Negative Regulation Of Secretion Plasma Membrane G Protein-coupled Receptor Signaling Pathway Regulation Of System Process Acetylcholine Receptor Signaling Pathway Regulation Of Muscle System Process Negative Regulation Of Transport Regulation Of Hormone Secretion Regulation Of Protein Secretion Regulation Of Protein Transport Diacylglycerol-dependent Serine/threonine Kinase Activity Regulation Of Cell Communication Regulation Of Signaling Angiotensin Receptor Binding Negative Regulation Of Hormone Secretion Regulation Of Insulin Secretion Positive Regulation Of Superoxide Anion Generation Negative Regulation Of Protein Secretion G Protein-coupled Serotonin Receptor Signaling Pathway Regulation Of Superoxide Anion Generation Regulation Of Biological Quality Regulation Of Establishment Of Protein Localization Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Peptide Hormone Secretion System Process Regulation Of Superoxide Metabolic Process Enzyme Binding Adenylate Cyclase Inhibitor Activity Adenylate Cyclase Regulator Activity	Membrane Plasma Membrane Protein Binding PH-gated Chloride Channel Activity Connexin Complex Gap Junction Channel Activity Gap Junction Immune Response-activating Cell Surface Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway G Protein-coupled Opioid Receptor Activity G Protein-coupled Receptor Activity Immune Response-regulating Cell Surface Receptor Signaling Pathway G Protein-coupled Opioid Receptor Signaling Pathway Immune System Process Immune Response-regulating Signaling Pathway
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