OPRD1 and GNAI2

Number of citations of the paper that reports this interaction (PubMedID 1671672)
0

Data Source:
HPRD (in vivo)

		OPRD1	GNAI2
Description		opioid receptor delta 1	G protein subunit alpha i2
Image
GO Annotations	Cellular Component	Plasma Membrane Membrane Synaptic Vesicle Membrane Vesicle Dendrite Membrane Presynaptic Membrane Neuron Projection Axon Terminus Postsynaptic Membrane Spine Apparatus Postsynaptic Density Membrane Neuronal Dense Core Vesicle	Nucleoplasm Cytoplasm Centrosome Cytosol Heterotrimeric G-protein Complex Cytoskeleton Plasma Membrane Membrane Dendrite Midbody Ciliary Basal Body Cell Body Extracellular Exosome Hippocampal Mossy Fiber To CA3 Synapse Neuronal Dense Core Vesicle Extracellular Vesicle
	Molecular Function	G Protein-coupled Receptor Activity G Protein-coupled Opioid Receptor Activity Protein Binding G Protein-coupled Peptide Receptor Activity Receptor Serine/threonine Kinase Binding G Protein-coupled Enkephalin Receptor Activity Neuropeptide Binding	Nucleotide Binding G Protein-coupled Receptor Binding GTPase Activity Protein Binding GTP Binding Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding Metal Ion Binding
	Biological Process	Immune Response Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Adult Locomotory Behavior Negative Regulation Of Gene Expression Negative Regulation Of Protein-containing Complex Assembly Response To Nicotine G Protein-coupled Opioid Receptor Signaling Pathway Eating Behavior Response To Ethanol Regulation Of Mitochondrial Membrane Potential Regulation Of Calcium Ion Transport Cellular Response To Growth Factor Stimulus Cellular Response To Hypoxia Cellular Response To Toxic Substance	G Protein-coupled Adenosine Receptor Signaling Pathway Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity G Protein-coupled Acetylcholine Receptor Signaling Pathway Gamma-aminobutyric Acid Signaling Pathway Response To Nutrient Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Positive Regulation Of Cell Migration Positive Regulation Of Superoxide Anion Generation Positive Regulation Of Urine Volume Negative Regulation Of Calcium Ion-dependent Exocytosis Modulation Of Chemical Synaptic Transmission Negative Regulation Of Synaptic Transmission Cell Division Regulation Of Calcium Ion Transport Positive Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Neural Precursor Cell Proliferation Negative Regulation Of Apoptotic Signaling Pathway
Pathways		Peptide ligand-binding receptors G alpha (i) signalling events Interleukin-4 and Interleukin-13 signaling	Adenylate cyclase inhibitory pathway Adenylate cyclase inhibitory pathway ADP signalling through P2Y purinoceptor 12 Adrenaline,noradrenaline inhibits insulin secretion Adrenaline,noradrenaline inhibits insulin secretion G alpha (s) signalling events G alpha (i) signalling events G alpha (i) signalling events G alpha (z) signalling events Regulation of insulin secretion Extra-nuclear estrogen signaling GPER1 signaling ADORA2B mediated anti-inflammatory cytokines production
Drugs		Tramadol Morphine Codeine Amitriptyline Hydromorphone Methadone Oxycodone Dextromethorphan Butorphanol Dextropropoxyphene Naltrexone Sufentanil Fentanyl Loperamide Nalbuphine Levorphanol Remifentanil Buprenorphine Hydrocodone Diphenoxylate Naloxone Oxymorphone Ketamine Aripiprazole 3-Methylthiofentanyl Dimethylthiambutene Diamorphine Etorphine Carfentanil Diprenorphine Dihydromorphine 3-Methylfentanyl ADL5859 Tapentadol Nalmefene Alvimopan Amisulpride Morphine glucuronide Ketobemidone Cannabidiol Butyrfentanyl Pholcodine Eluxadoline Opium Naldemedine Samidorphan Metenkefalin Medical Cannabis Nabiximols Loxicodegol
Diseases			Adrenal carcinoma
GWAS		Tourette syndrome ( 30818990)	Body mass index ( 26426971) Body size at age 10 ( 32376654) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Caffeine consumption from tea ( 33287642) Cortical surface area (MOSTest) ( 32665545) Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 32888494) Morning person ( 30696823) Sleep duration (short sleep) ( 30846698) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		22 interacting genes: ADRB2 ARRB1 ARRB2 CTXN3 GNA15 GNAI1 GNAI2 GNAO1 GNAZ GPRASP1 GRK2 KLHL3 OPRK1 OPRM1 PRKCA PRKCD PRKCE RPRM SLC12A7 SLC13A4 SMAGP TMEM237	66 interacting genes: ADCY1 ADORA1 ADRA2A ADRA2B ADRB2 AGTR2 C5AR1 CAV1 CCR5 CHRM1 CNR1 CRYAA CXCL8 CXCR1 CXCR2 DRD2 EDNRA EGFR EYA1 EYA2 F2R FPR1 GNB2 GNB4 GPSM2 GPSM3 IGF1R ITCH KRT31 KRT40 KRTAP10-8 LHB LHCGR LPAR3 LTB4R MDFI MRGPRX1 MTNR1A MTNR1B NGB NOTCH2NLA NPM1 NUCB1 OPRD1 OPRM1 P2RY12 PCP2 PLSCR1 PTEN PTPRU RASD1 RGS12 RGS14 RGS16 RGS18 RGS19 RGS20 RGS4 RGS5 RIC8A TBXA2R TNFAIP3 TRIP6 TSHR TTC1 TUBA4A
Entrez ID		4985	2771
HPRD ID		01308	00764
Ensembl ID		ENSG00000116329	ENSG00000114353
Uniprot IDs		P41143	B3KP24 B3KX51 P04899
PDB IDs		4N6H 4RWA 4RWD 6PT2 6PT3 8F7S 8Y45	6D9H 7F8V 7LD3 7LD4 7WV9 7WVV 7WVW 7WVX 7WVY 7XXI 7YJ4 7YK6 7YK7 8K6M 8K6N 8K6O 8KGG 8THK 8THL 8Y45 8ZSJ 8ZSP 8ZSS 8ZSV
Enriched GO Terms of Interacting Partners?		G Protein-coupled Receptor Binding Guanyl Nucleotide Binding Negative Regulation Of G Protein-coupled Receptor Signaling Pathway G-protein Beta/gamma-subunit Complex Binding Heterotrimeric G-protein Complex Regulation Of G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway G Protein-coupled Serotonin Receptor Binding Postsynaptic Signal Transduction Regulation Of Transport Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway G Protein-coupled Acetylcholine Receptor Signaling Pathway Regulation Of Secretion By Cell Negative Regulation Of Secretion By Cell Desensitization Of G Protein-coupled Receptor Signaling Pathway Regulation Of Secretion Positive Regulation Of MAPK Cascade Negative Regulation Of Cell Communication Regulation Of MAPK Cascade Negative Regulation Of Signaling Negative Adaptation Of Signaling Pathway Negative Regulation Of Secretion Plasma Membrane G Protein-coupled Receptor Signaling Pathway Regulation Of System Process Acetylcholine Receptor Signaling Pathway Regulation Of Muscle System Process Negative Regulation Of Transport Regulation Of Hormone Secretion Regulation Of Protein Secretion Regulation Of Protein Transport Diacylglycerol-dependent Serine/threonine Kinase Activity Regulation Of Cell Communication Regulation Of Signaling Angiotensin Receptor Binding Negative Regulation Of Hormone Secretion Regulation Of Insulin Secretion Positive Regulation Of Superoxide Anion Generation Negative Regulation Of Protein Secretion G Protein-coupled Serotonin Receptor Signaling Pathway Regulation Of Superoxide Anion Generation Regulation Of Biological Quality Regulation Of Establishment Of Protein Localization Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Peptide Hormone Secretion System Process Regulation Of Superoxide Metabolic Process Enzyme Binding Adenylate Cyclase Inhibitor Activity Adenylate Cyclase Regulator Activity	G Protein-coupled Receptor Signaling Pathway Signal Transduction G Protein-coupled Receptor Activity Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Plasma Membrane G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger G-protein Alpha-subunit Binding Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of Cell Communication Negative Regulation Of Signaling Positive Regulation Of Cytosolic Calcium Ion Concentration Inflammatory Response Regulation Of Monoatomic Ion Transport Regulation Of Biological Quality Negative Regulation Of Signal Transduction Blood Vessel Diameter Maintenance Regulation Of Tube Size Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of MAPK Cascade Intracellular Signaling Cassette Cell Surface Receptor Signaling Pathway System Process Signaling Regulation Of Blood Circulation Cell Communication Positive Regulation Of Cell Communication Regulation Of Metal Ion Transport Positive Regulation Of MAPK Cascade Positive Regulation Of Signaling Nervous System Process Positive Regulation Of Monoatomic Ion Transport GTPase Regulator Activity Response To Stress Cell-cell Signaling Vascular Process In Circulatory System Negative Regulation Of Transport Positive Regulation Of Signal Transduction Regulation Of Locomotion Regulation Of Smooth Muscle Contraction Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Cell Migration Regulation Of Vasoconstriction Regulation Of System Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Blood Pressure Regulation Of Intracellular Signal Transduction
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