SYN3 and MORF4L2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SYN3	MORF4L2
Description		synapsin III	mortality factor 4 like 2
Image			No pdb structure
GO Annotations	Cellular Component	Synaptic Vesicle Postsynaptic Density Membrane Synaptic Vesicle Membrane Cytoplasmic Vesicle Synapse Extrinsic Component Of Synaptic Vesicle Membrane Glutamatergic Synapse	Nucleosome Nucleus Nucleoplasm Nucleolus Plasma Membrane NuA4 Histone Acetyltransferase Complex
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding	Protein Binding
	Biological Process	Chemical Synaptic Transmission Neurotransmitter Secretion Regulation Of Synaptic Transmission, GABAergic Modulation Of Chemical Synaptic Transmission Synapse Organization Synaptic Vesicle Clustering Synaptic Vesicle Cycle	DNA Repair Chromatin Organization Regulation Of DNA-templated Transcription DNA Damage Response Regulation Of Apoptotic Process Positive Regulation Of DNA-templated Transcription Regulation Of Cell Cycle Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Double-strand Break Repair
Pathways		Serotonin Neurotransmitter Release Cycle Dopamine Neurotransmitter Release Cycle	HATs acetylate histones
Drugs
Diseases
GWAS		Advanced age-related macular degeneration ( 26691988) Age-related macular degeneration ( 20385819) Alzheimer's disease progression score ( 29860282) Benign prostatic hyperplasia ( 30988330) Chronic obstructive pulmonary disease ( 30804561) Femoral neck bone mineral density and trunk fat mass adjusted by trunk lean mass ( 32239398) Heel bone mineral density ( 30598549) Height ( 20881960 21998595 25282103 25429064 31562340) Interleukin-6 levels ( 22205395) Intracranial aneurysm ( 29531279) Intraocular pressure ( 29785010 31959993 30054594 29617998) Metabolite levels ( 23823483) Refractive error ( 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Triglyceride levels ( 31170924) Trunk fat mass adjusted for trunk lean mass ( 32239398)	Lymphocyte percentage of white cells ( 32888494) Mean platelet volume ( 32888494)
Interacting Genes		8 interacting genes: C9orf72 MORF4L1 MORF4L2 NOS1AP PIAS2 SNCA SYN1 SYN2	54 interacting genes: AMOTL2 ARID3A BCL11A BEND7 BEX5 CAMK2B CDR2 CEP55 DDIT4L DISC1 DSCAM EVI5 FAM9B FBXO16 GOLGA2 GPBP1 GRAMD2B HDAC1 HMBOX1 HOMEZ HUNK IKZF1 KCTD1 KLHL3 L3MBTL3 LUZP4 LZTS2 MEOX2 MRFAP1 MRGBP MRPL12 NAB2 PHC2 PIBF1 PICK1 PNMA2 POU6F2 RB1 REL SIN3A SYN3 THAP1 TLE1 TLE5 TNIP1 TNNT2 TRIM41 TSN ZBTB10 ZBTB14 ZBTB26 ZBTB43 ZBTB7B ZNF48
Entrez ID		8224	9643
HPRD ID		04083	02326
Ensembl ID		ENSG00000185666	ENSG00000123562
Uniprot IDs		O14994 Q17R54 Q59EX7	Q15014
PDB IDs		2P0A
Enriched GO Terms of Interacting Partners?		Neurotransmitter Secretion Synaptic Vesicle Cycle Vesicle-mediated Transport In Synapse Neurotransmitter Transport Synaptic Vesicle Clustering Vesicle Localization Regulation Of Synaptic Vesicle Cycle Synaptic Vesicle Membrane Synaptic Vesicle Signal Release Regulation Of Exocytosis NuA4 Histone Acetyltransferase Complex Negative Regulation Of Exocytosis Presynapse Synapse Organization Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Chemical Synaptic Transmission Response To Desipramine Negative Regulation Of Norepinephrine Uptake Trans-synaptic Signaling Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Synaptic Signaling Synapse Positive Regulation Of DNA Recombination Axon Secretion By Cell Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Neurotransmitter Secretion Regulated Exocytosis Regulation Of Norepinephrine Uptake Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Organelle Localization Positive Regulation Of Hydrogen Peroxide Catabolic Process Cell Junction Organization Schaffer Collateral - CA1 Synapse Positive Regulation Of Double-strand Break Repair Negative Regulation Of Serotonin Uptake Transporter Regulator Activity Positive Regulation Of Monoatomic Ion Transmembrane Transport Positive Regulation Of Cation Transmembrane Transport Secretion Negative Regulation Of Chaperone-mediated Autophagy Vesicle-mediated Transport Nucleosome Positive Regulation Of Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential Positive Regulation Of Membrane Repolarization During Cardiac Muscle Cell Action Potential Negative Regulation Of Dopamine Metabolic Process Growth Cone	Identical Protein Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of RNA Metabolic Process DNA Binding Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Protein Binding Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Transcription Corepressor Activity Regulation Of Primary Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Gene Expression Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Nucleus Nucleoplasm Regulation Of Axon Extension RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity Importin-alpha Family Protein Binding Positive Regulation Of Cell Development Positive Regulation Of Neurogenesis Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Neurogenesis
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