GPRIN2 and HTR4

Number of citations: 90 (PubMedID 28298427)
Data Source: BioGRID (affinity chromatography technology, imaging technique, two hybrid)

		GPRIN2	HTR4
Name		G protein regulated inducer of neurite outgrowth 2	5-hydroxytryptamine receptor 4
Structure		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane	Cytoplasm Endosome Plasma Membrane Endosome Membrane Membrane Dendrite Postsynapse Glutamatergic Synapse
	Molecular Function	Protein Binding	G Protein-coupled Receptor Activity G Protein-coupled Serotonin Receptor Activity Protein Binding Neurotransmitter Receptor Activity Serotonin Binding Serotonin Receptor Activity
	Biological Process	Neuron Projection Development	System Process Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating Serotonin Receptor Signaling Pathway Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Chemical Synaptic Transmission Maintenance Of Gastrointestinal Epithelium Regulation Of Appetite Mucus Secretion Large Intestinal Transit Regulation Of Postsynapse Assembly
Pathways		None	Serotonin receptors G alpha (s) signalling events
Drugs		None	Dihydroergotamine Cisapride Paroxetine Ondansetron Ergoloid mesylate Tegaserod Metoclopramide Chlorprothixene Piboserod Renzapride Naronapride TD-2749 Ticalopride Prucalopride Cinitapride Setiptiline Dihydroergocornine Gilteritinib Velusetrag Tiapride Dihydroergocristine
GWAS		No GWAS studies recorded	Airflow obstruction ( 22837378 ) Chronic obstructive pulmonary disease ( 30804561 28166215 ) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143 ) Diastolic blood pressure ( 30578418 ) FEV1 ( 30804560 ) Hematocrit ( 32888494 ) Hemoglobin ( 32888494 ) Lung function (FEV1) ( 28166213 ) Lung function (FEV1/FVC) ( 28166213 30804560 ) Lung function (FVC) ( 30804560 ) Lung function (low FEV1 vs high FEV1) ( 26423011 ) Lung function in heavy smokers (low FEV1 vs high FEV1) ( 26423011 ) Medication use (adrenergics, inhalants) ( 31015401 ) Mood instability ( 31168069 ) Peak expiratory flow ( 30804560 ) Periodontal microbiota ( 22699663 ) Pulmonary function ( 20010835 20010834 ) Pulmonary function (smoking interaction) ( 23284291 ) Systolic blood pressure ( 30578418 ) Urinary sodium excretion ( 31409800 )
Interacting Genes		27 interacting genes: ANKS1A BCAP31 CYSRT1 DYNLL1 DYNLL2 FRS3 HAPLN2 HTR4 KRTAP10-3 KRTAP10-5 KRTAP10-8 KRTAP12-1 KRTAP12-2 KRTAP12-4 KRTAP4-12 KRTAP4-7 LNP1 MDFI OTX1 PLSCR1 RHOU SFN SPRY2 TRIM55 TRIM63 TRIP13 YWHAE	18 interacting genes: ADRB2 ANO10 CD81 CERS1 CLDN10 CLTB ELOVL5 GDF1 GGT7 GHITM GPR37 GPRIN2 MGLL SARAF SLC39A1 TMEFF2 TMEM230 TSPAN7
Entrez ID		9721	3360
HPRD ID		13804	09074
Ensembl ID		ENSG00000204175	ENSG00000164270
Uniprot IDs		O60269	A0A2D3FAF9 Q13639
PDB IDs		Not available	5EM9 7XT8 7XT9 7XTA
GO Terms Enriched among Interactors		Intermediate Filament Keratin Filament Positive Regulation Of Establishment Of Protein Localization Phosphoserine Residue Binding Protein Sequestering Activity Positive Regulation Of Intracellular Transport Identical Protein Binding Regulation Of Establishment Of Protein Localization Scaffold Protein Binding Microtubule Protein Localization To Endoplasmic Reticulum Positive Regulation Of Protein Export From Nucleus Positive Regulation Of Intracellular Protein Transport	Membrane Endoplasmic Reticulum Membrane