HTR4

Gene Name		5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Endosome Plasma Membrane Integral Component Of Plasma Membrane Membrane
	Molecular Function	Serotonin Receptor Activity
	Biological Process	G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Serotonin Receptor Signaling Pathway Synaptic Transmission Positive Regulation Of Cell Proliferation Regulation Of Appetite
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling G alpha (s) signalling events Class A/1 (Rhodopsin-like receptors) Amine ligand-binding receptors Metabolic disorders of biological oxidation enzymes GPCR ligand binding Serotonin receptors
Drugs		Cisapride Ondansetron Tegaserod Metoclopramide Cinitapride
Diseases
GWAS		Airflow obstruction ( 22837378) Periodontal microbiota ( 22699663) Pulmonary function ( 20010834 20010835) Pulmonary function (interaction) ( 23284291)
Protein-protein Interactions		1 interactors: ADRB2
Entrez ID		3360
HPRD ID		09074
Ensembl ID		ENSG00000164270
Uniprot IDs		Q13639
PDB IDs
Enriched GO Terms of Interacting Partners?		Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway By Arrestin Vasodilation By Norepinephrine-epinephrine Involved In Regulation Of Systemic Arterial Blood Pressure Heat Generation Diet Induced Thermogenesis Activation Of Transmembrane Receptor Protein Tyrosine Kinase Activity Negative Regulation Of Smooth Muscle Contraction Adrenergic Receptor Signaling Pathway Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway Response To Dietary Excess Negative Regulation Of Multicellular Organism Growth Negative Regulation Of Muscle Contraction Negative Regulation Of Systemic Arterial Blood Pressure Temperature Homeostasis Activation Of Adenylate Cyclase Activity Endosome To Lysosome Transport Vasodilation Bone Resorption Positive Regulation Of Adenylate Cyclase Activity Positive Regulation Of Bone Mineralization Positive Regulation Of Biomineral Tissue Development Brown Fat Cell Differentiation Lysosomal Transport Regulation Of Vasodilation Positive Regulation Of Lyase Activity Negative Regulation Of Blood Pressure Regulation Of Smooth Muscle Contraction Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Protein Binding Regulation Of Adenylate Cyclase Activity Response To Cold Bone Remodeling Positive Regulation Of CAMP Biosynthetic Process Regulation Of Cyclase Activity Regulation Of Sodium Ion Transport Positive Regulation Of CAMP Metabolic Process Regulation Of Bone Mineralization Regulation Of Blood Vessel Size Regulation Of Tube Size Vacuolar Transport Positive Regulation Of Cyclic Nucleotide Metabolic Process Negative Regulation Of Developmental Growth Regulation Of CAMP Biosynthetic Process Regulation Of Systemic Arterial Blood Pressure Positive Regulation Of Ossification Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Negative Regulation Of Binding Regulation Of Multicellular Organism Growth Regulation Of CAMP Metabolic Process Tissue Remodeling Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway
Tagcloud ?		56x10 58x10 adam19 allele ancestry associations causal conditioning consortium expiratory fev1 forced fvc gwas gwass harboring hit kernel minor nucleotide polymorphisms rs11168048 rs13155908 rs1422795 sentinel tagged uncertain underlie variants