HTR4

Name	5-hydroxytryptamine receptor 4
Structure
Interactors	18 interactors: ADRB2 ANO10 CD81 CERS1 CLDN10 CLTB ELOVL5 GDF1 GGT7 GHITM GPR37 GPRIN2 MGLL SARAF SLC39A1 TMEFF2 TMEM230 TSPAN7
GO Annotations	Cellular Component	Cytoplasm Endosome Plasma Membrane Endosome Membrane Membrane Dendrite Postsynapse Glutamatergic Synapse
	Molecular Function	G Protein-coupled Receptor Activity G Protein-coupled Serotonin Receptor Activity Protein Binding Neurotransmitter Receptor Activity Serotonin Binding Serotonin Receptor Activity
	Biological Process	System Process Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating Serotonin Receptor Signaling Pathway Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Chemical Synaptic Transmission Maintenance Of Gastrointestinal Epithelium Regulation Of Appetite Mucus Secretion Large Intestinal Transit Regulation Of Postsynapse Assembly
Pathways	Serotonin receptors G alpha (s) signalling events
Drugs	Dihydroergotamine Cisapride Paroxetine Ondansetron Ergoloid mesylate Tegaserod Metoclopramide Chlorprothixene Piboserod Renzapride Naronapride TD-2749 Ticalopride Prucalopride Cinitapride Setiptiline Dihydroergocornine Gilteritinib Velusetrag Tiapride Dihydroergocristine
GWAS	Airflow obstruction ( 22837378 ) Chronic obstructive pulmonary disease ( 30804561 28166215 ) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143 ) Diastolic blood pressure ( 30578418 ) FEV1 ( 30804560 ) Hematocrit ( 32888494 ) Hemoglobin ( 32888494 ) Lung function (FEV1) ( 28166213 ) Lung function (FEV1/FVC) ( 28166213 30804560 ) Lung function (FVC) ( 30804560 ) Lung function (low FEV1 vs high FEV1) ( 26423011 ) Lung function in heavy smokers (low FEV1 vs high FEV1) ( 26423011 ) Medication use (adrenergics, inhalants) ( 31015401 ) Mood instability ( 31168069 ) Peak expiratory flow ( 30804560 ) Periodontal microbiota ( 22699663 ) Pulmonary function ( 20010835 20010834 ) Pulmonary function (smoking interaction) ( 23284291 ) Systolic blood pressure ( 30578418 ) Urinary sodium excretion ( 31409800 )
Entrez ID	3360
HPRD ID	09074
Ensembl ID	ENSG00000164270
Uniprot IDs	A0A2D3FAF9 Q13639
PDB IDs	5EM9 7XT8 7XT9 7XTA
GO Terms Enriched among Interactors ?	Membrane Endoplasmic Reticulum Membrane