HTR4 and ANO10

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		HTR4	ANO10
Description		5-hydroxytryptamine receptor 4	anoctamin 10
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GO Annotations	Cellular Component	Cytoplasm Endosome Plasma Membrane Endosome Membrane Membrane Dendrite Postsynapse Glutamatergic Synapse	Plasma Membrane Cilium Membrane
	Molecular Function	G Protein-coupled Receptor Activity G Protein-coupled Serotonin Receptor Activity Protein Binding Neurotransmitter Receptor Activity Serotonin Binding Serotonin Receptor Activity	Calcium-activated Cation Channel Activity Intracellularly Calcium-gated Chloride Channel Activity Chloride Channel Activity
	Biological Process	System Process Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating Serotonin Receptor Signaling Pathway Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Chemical Synaptic Transmission Maintenance Of Gastrointestinal Epithelium Regulation Of Appetite Mucus Secretion Large Intestinal Transit Regulation Of Postsynapse Assembly	Monoatomic Ion Transmembrane Transport Monoatomic Cation Transmembrane Transport Chloride Transmembrane Transport
Pathways		Serotonin receptors G alpha (s) signalling events	Stimuli-sensing channels Induction of Cell-Cell Fusion
Drugs		Dihydroergotamine Cisapride Paroxetine Ondansetron Ergoloid mesylate Tegaserod Metoclopramide Chlorprothixene Piboserod Renzapride Naronapride TD-2749 Ticalopride Prucalopride Cinitapride Setiptiline Dihydroergocornine Gilteritinib Velusetrag Tiapride Dihydroergocristine
Diseases			Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)
GWAS		Airflow obstruction ( 22837378) Chronic obstructive pulmonary disease ( 30804561 28166215) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Diastolic blood pressure ( 30578418) FEV1 ( 30804560) Hematocrit ( 32888494) Hemoglobin ( 32888494) Lung function (FEV1) ( 28166213) Lung function (FEV1/FVC) ( 28166213 30804560) Lung function (FVC) ( 30804560) Lung function (low FEV1 vs high FEV1) ( 26423011) Lung function in heavy smokers (low FEV1 vs high FEV1) ( 26423011) Medication use (adrenergics, inhalants) ( 31015401) Mood instability ( 31168069) Peak expiratory flow ( 30804560) Periodontal microbiota ( 22699663) Pulmonary function ( 20010835 20010834) Pulmonary function (smoking interaction) ( 23284291) Systolic blood pressure ( 30578418) Urinary sodium excretion ( 31409800)	A body shape index ( 34021172) Gastroesophageal reflux disease ( 31527586) Obesity-related traits ( 23251661) Primary central nervous system lymphoma ( 31102405) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		18 interacting genes: ADRB2 ANO10 CD81 CERS1 CLDN10 CLTB ELOVL5 GDF1 GGT7 GHITM GPR37 GPRIN2 MGLL SARAF SLC39A1 TMEFF2 TMEM230 TSPAN7	2 interacting genes: HTR4 SMARCA2
Entrez ID		3360	55129
HPRD ID		09074	07667
Ensembl ID		ENSG00000164270	ENSG00000160746
Uniprot IDs		A0A2D3FAF9 Q13639	Q9NW15
PDB IDs		5EM9 7XT8 7XT9 7XTA	5OC9 6R65 6R7X 6R7Y 6R7Z
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane	Large Intestinal Transit Adenylate Cyclase-activating Serotonin Receptor Signaling Pathway Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway G Protein-coupled Serotonin Receptor Activity Serotonin Receptor Activity Serotonin Receptor Signaling Pathway Mucus Secretion Serotonin Binding BBAF Complex Brahma Complex NBAF Complex Nucleosome Array Spacer Activity NpBAF Complex GBAF Complex Neurotransmitter Receptor Activity G Protein-coupled Serotonin Receptor Signaling Pathway Maintenance Of Gastrointestinal Epithelium Regulation Of Appetite
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