HTR4 and GGT7

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		HTR4	GGT7
Description		5-hydroxytryptamine receptor 4	gamma-glutamyltransferase 7
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endosome Plasma Membrane Endosome Membrane Membrane Dendrite Postsynapse Glutamatergic Synapse	Plasma Membrane Membrane
	Molecular Function	G Protein-coupled Receptor Activity G Protein-coupled Serotonin Receptor Activity Protein Binding Neurotransmitter Receptor Activity Serotonin Binding Serotonin Receptor Activity	Protein Binding Transferase Activity Acyltransferase Activity Hydrolase Activity Glutathione Hydrolase Activity Leukotriene C4 Gamma-glutamyl Transferase Activity
	Biological Process	System Process Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating Serotonin Receptor Signaling Pathway Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Chemical Synaptic Transmission Maintenance Of Gastrointestinal Epithelium Regulation Of Appetite Mucus Secretion Large Intestinal Transit Regulation Of Postsynapse Assembly	Glutathione Metabolic Process Glutathione Biosynthetic Process Glutathione Catabolic Process Leukotriene D4 Biosynthetic Process Negative Regulation Of Response To Oxidative Stress
Pathways		Serotonin receptors G alpha (s) signalling events	Glutathione synthesis and recycling Aflatoxin activation and detoxification Paracetamol ADME
Drugs		Dihydroergotamine Cisapride Paroxetine Ondansetron Ergoloid mesylate Tegaserod Metoclopramide Chlorprothixene Piboserod Renzapride Naronapride TD-2749 Ticalopride Prucalopride Cinitapride Setiptiline Dihydroergocornine Gilteritinib Velusetrag Tiapride Dihydroergocristine
Diseases
GWAS		Airflow obstruction ( 22837378) Chronic obstructive pulmonary disease ( 30804561 28166215) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Diastolic blood pressure ( 30578418) FEV1 ( 30804560) Hematocrit ( 32888494) Hemoglobin ( 32888494) Lung function (FEV1) ( 28166213) Lung function (FEV1/FVC) ( 28166213 30804560) Lung function (FVC) ( 30804560) Lung function (low FEV1 vs high FEV1) ( 26423011) Lung function in heavy smokers (low FEV1 vs high FEV1) ( 26423011) Medication use (adrenergics, inhalants) ( 31015401) Mood instability ( 31168069) Peak expiratory flow ( 30804560) Periodontal microbiota ( 22699663) Pulmonary function ( 20010835 20010834) Pulmonary function (smoking interaction) ( 23284291) Systolic blood pressure ( 30578418) Urinary sodium excretion ( 31409800)	Bipolar disorder ( 31043756) Coronary artery disease ( 29212778) Estimated glomerular filtration rate ( 31451708) Fish- and plant-related diet ( 32066663) Hip circumference adjusted for BMI ( 34021172) Reticulocyte fraction of red cells ( 32888494) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		18 interacting genes: ADRB2 ANO10 CD81 CERS1 CLDN10 CLTB ELOVL5 GDF1 GGT7 GHITM GPR37 GPRIN2 MGLL SARAF SLC39A1 TMEFF2 TMEM230 TSPAN7	12 interacting genes: CLDN19 CMTM7 CYB561 GPR25 HTR4 LNPEP MALL MTNR1B SLC35A4 TLCD3A TMEM242 TSPO2
Entrez ID		3360	2686
HPRD ID		09074	07488
Ensembl ID		ENSG00000164270	ENSG00000131067
Uniprot IDs		A0A2D3FAF9 Q13639	A0PJJ9 Q9UJ14
PDB IDs		5EM9 7XT8 7XT9 7XTA
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane	Membrane G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Large Intestinal Transit Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-independent 5-aminolevulinic Acid Import Across Plasma Membrane 5-aminolevulinic Acid Transmembrane Transporter Activity
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