HTR4 and CLTB

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		HTR4	CLTB
Description		5-hydroxytryptamine receptor 4	clathrin light chain B
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endosome Plasma Membrane Endosome Membrane Membrane Dendrite Postsynapse Glutamatergic Synapse	Trans-Golgi Network Cytosol Plasma Membrane Clathrin-coated Pit Membrane Clathrin Coat Clathrin Vesicle Coat Clathrin Coat Of Trans-Golgi Network Vesicle Clathrin Coat Of Coated Pit Cytoplasmic Vesicle Membrane Synaptic Vesicle Membrane Cytoplasmic Vesicle Clathrin-coated Endocytic Vesicle Ciliary Membrane Presynaptic Endocytic Zone Membrane
	Molecular Function	G Protein-coupled Receptor Activity G Protein-coupled Serotonin Receptor Activity Protein Binding Neurotransmitter Receptor Activity Serotonin Binding Serotonin Receptor Activity	Structural Molecule Activity Protein Binding Clathrin Heavy Chain Binding Peptide Binding
	Biological Process	System Process Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating Serotonin Receptor Signaling Pathway Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Chemical Synaptic Transmission Maintenance Of Gastrointestinal Epithelium Regulation Of Appetite Mucus Secretion Large Intestinal Transit Regulation Of Postsynapse Assembly	Intracellular Protein Transport Vesicle-mediated Transport Synaptic Vesicle Endocytosis Clathrin-dependent Endocytosis
Pathways		Serotonin receptors G alpha (s) signalling events	Gap junction degradation Formation of annular gap junctions EPH-ephrin mediated repulsion of cells Lysosome Vesicle Biogenesis WNT5A-dependent internalization of FZD4 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs		Dihydroergotamine Cisapride Paroxetine Ondansetron Ergoloid mesylate Tegaserod Metoclopramide Chlorprothixene Piboserod Renzapride Naronapride TD-2749 Ticalopride Prucalopride Cinitapride Setiptiline Dihydroergocornine Gilteritinib Velusetrag Tiapride Dihydroergocristine
Diseases
GWAS		Airflow obstruction ( 22837378) Chronic obstructive pulmonary disease ( 30804561 28166215) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Diastolic blood pressure ( 30578418) FEV1 ( 30804560) Hematocrit ( 32888494) Hemoglobin ( 32888494) Lung function (FEV1) ( 28166213) Lung function (FEV1/FVC) ( 28166213 30804560) Lung function (FVC) ( 30804560) Lung function (low FEV1 vs high FEV1) ( 26423011) Lung function in heavy smokers (low FEV1 vs high FEV1) ( 26423011) Medication use (adrenergics, inhalants) ( 31015401) Mood instability ( 31168069) Peak expiratory flow ( 30804560) Periodontal microbiota ( 22699663) Pulmonary function ( 20010835 20010834) Pulmonary function (smoking interaction) ( 23284291) Systolic blood pressure ( 30578418) Urinary sodium excretion ( 31409800)	Obesity-related traits ( 23251661)
Interacting Genes		18 interacting genes: ADRB2 ANO10 CD81 CERS1 CLDN10 CLTB ELOVL5 GDF1 GGT7 GHITM GPR37 GPRIN2 MGLL SARAF SLC39A1 TMEFF2 TMEM230 TSPAN7	11 interacting genes: CALM1 CEBPA CLTC CSNK2A1 CSNK2A2 HIP1 HIP1R HTR4 MYO6 PQBP1 SNCA
Entrez ID		3360	1212
HPRD ID		09074	00352
Ensembl ID		ENSG00000164270	ENSG00000175416
Uniprot IDs		A0A2D3FAF9 Q13639	B4DTF9 P09497
PDB IDs		5EM9 7XT8 7XT9 7XTA
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane	Clathrin Light Chain Binding Endocytosis Clathrin-coated Vesicle Clathrin Coat Assembly Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Import Into Cell Protein Kinase CK2 Complex Positive Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Clathrin-coated Vesicle Membrane Positive Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Clathrin-coated Pit Postsynapse Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Vesicle-mediated Transport Protein-containing Complex Regulation Of Protein Catabolic Process Regulation Of Protein Stability Negative Regulation Of Protein Catabolic Process Clathrin Adaptor Activity Phospholipid Binding Actin Binding Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Clathrin-coated Endocytic Vesicle PcG Protein Complex Phosphatidylinositol-3,4-bisphosphate Binding Phosphatidylinositol-3,5-bisphosphate Binding Regulation Of Ubiquitin-dependent Protein Catabolic Process Receptor-mediated Endocytosis Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Cell Cortex Supramolecular Fiber Organization Positive Regulation Of ERBB Signaling Pathway Clathrin Binding Regulation Of Proteasomal Protein Catabolic Process Regulation Of Cellular Component Organization Actin Filament Binding Regulation Of Cell Cycle Presynaptic Endocytosis Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Stabilization Long-term Synaptic Potentiation Mitochondrion Organization Animal Organ Regeneration RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Regulation Of Macrophage Activation Actin Filament Organization Cortical Actin Cytoskeleton Large Intestinal Transit Minus-end Directed Microfilament Motor Activity Response To Desipramine
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