GPRIN2 and ARHGAP22

Data Source: HiPPIP (Novel)

		GPRIN2	ARHGAP22
Name		G protein regulated inducer of neurite outgrowth 2	Rho GTPase activating protein 22
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane	Nucleus Cytoplasm Cytosol Focal Adhesion Glutamatergic Synapse
	Molecular Function	Protein Binding	GTPase Activator Activity Protein Binding
	Biological Process	Neuron Projection Development	Angiogenesis Signal Transduction Cell Differentiation Regulation Of Small GTPase Mediated Signal Transduction Negative Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Postsynapse Organization
Pathways		None	RHOA GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle
GWAS		No GWAS studies recorded	Conduct disorder ( 20585324 ) Daytime sleep phenotypes ( 27126917 ) Diabetic retinopathy ( 21310492 ) Femur bone mineral density x serum urate levels interaction ( 34046847 ) Macular thickness ( 30535121 ) Refractive error ( 32231278 ) Self-employment ( 23593239 ) Systolic blood pressure ( 31134134 ) Systolic blood pressure (education interaction) ( 31134134 )
Novel Interactors		3 novel interactors: ARHGAP22 MAPK8 WDFY4	5 novel interactors: ALG11 GPRIN2 MAPK8 PTPN20 ZNF488
Interacting Genes		27 interacting genes: ANKS1A BCAP31 CYSRT1 DYNLL1 DYNLL2 FRS3 HAPLN2 HTR4 KRTAP10-3 KRTAP10-5 KRTAP10-8 KRTAP12-1 KRTAP12-2 KRTAP12-4 KRTAP4-12 KRTAP4-7 LNP1 MDFI OTX1 PLSCR1 RHOU SFN SPRY2 TRIM55 TRIM63 TRIP13 YWHAE	8 interacting genes: CACNA1A CCNDBP1 CDC42 DEF6 FXR1 IL1RAPL1 RAC1 RHOA
Entrez ID		9721	58504
HPRD ID		13804	12476
Ensembl ID		ENSG00000204175	ENSG00000128805
Uniprot IDs		O60269	A0A2X0SFC0 Q7Z5H3
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Intermediate Filament Keratin Filament Positive Regulation Of Establishment Of Protein Localization Phosphoserine Residue Binding Protein Sequestering Activity Positive Regulation Of Intracellular Transport Identical Protein Binding Regulation Of Establishment Of Protein Localization Scaffold Protein Binding Microtubule Protein Localization To Endoplasmic Reticulum Positive Regulation Of Protein Export From Nucleus Positive Regulation Of Intracellular Protein Transport	Positive Regulation Of Stress Fiber Assembly Wnt Signaling Pathway, Planar Cell Polarity Pathway Membrane Invagination Non-canonical Wnt Signaling Pathway Positive Regulation Of Actin Filament Bundle Assembly Cell Projection G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Dendrite G Protein Activity Postsynapse Positive Regulation Of Cellular Component Biogenesis Thioesterase Binding Cytoplasmic Ribonucleoprotein Granule Glutamatergic Synapse Regulation Of Stress Fiber Assembly Regulation Of Synapse Organization Establishment Of Epithelial Cell Apical/basal Polarity GTP-dependent Protein Binding Establishment Of Apical/basal Cell Polarity Establishment Of Monopolar Cell Polarity Establishment Or Maintenance Of Monopolar Cell Polarity Polarized Epithelial Cell Differentiation Regulation Of Postsynapse Organization Positive Regulation Of Lamellipodium Assembly Positive Regulation Of Rho Protein Signal Transduction Cerebral Cortex Cell Migration Establishment Of Epithelial Cell Polarity Establishment Or Maintenance Of Cell Polarity Regulation Of Protein-containing Complex Assembly Phagocytosis, Engulfment Regulation Of Cell Development Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Cell Development Cell-cell Junction Organization Positive Regulation Of Lamellipodium Organization Positive Regulation Of Cytoskeleton Organization Regulation Of Lamellipodium Assembly Positive Regulation Of Dendritic Spine Development Positive Regulation Of Protein-containing Complex Assembly Telencephalon Cell Migration Semaphorin-plexin Signaling Pathway Positive Regulation Of Cytokinesis Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Substantia Nigra Development Substrate Adhesion-dependent Cell Spreading Regulation Of Cell-substrate Adhesion Forebrain Cell Migration Positive Regulation Of Neurogenesis Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Establishment Or Maintenance Of Apical/basal Cell Polarity