CD69 and ATP6V0C

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CD69	ATP6V0C
Description		CD69 molecule	ATPase H+ transporting V0 subunit c
Image
GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Protein-containing Complex	Golgi Membrane Vacuolar Proton-transporting V-type ATPase, V0 Domain Lysosomal Membrane Plasma Membrane Focal Adhesion Endosome Membrane Membrane Clathrin-coated Vesicle Membrane Phagocytic Vesicle Membrane Synaptic Vesicle Membrane Cytoplasmic Vesicle Proton-transporting V-type ATPase Complex Proton-transporting Two-sector ATPase Complex, Proton-transporting Domain Proton-transporting V-type ATPase, V0 Domain Azurophil Granule Membrane Synapse Extracellular Exosome Tertiary Granule Membrane Bounding Membrane Of Organelle Ficolin-1-rich Granule Membrane
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding Carbohydrate Binding Identical Protein Binding Molecular Sequestering Activity	Protein Binding Proton Transmembrane Transporter Activity Ubiquitin Protein Ligase Binding Proton-transporting ATP Synthase Activity, Rotational Mechanism Proton-transporting ATPase Activity, Rotational Mechanism
	Biological Process	Sphingosine-1-phosphate Receptor Signaling Pathway Cellular Response To Xenobiotic Stimulus T Cell Migration Negative Regulation Of T-helper 17 Cell Lineage Commitment Negative Regulation Of T Cell Migration	Monoatomic Ion Transport Vacuolar Acidification Lysosomal Lumen Acidification Proton Motive Force-driven ATP Synthesis Regulation Of Macroautophagy Positive Regulation Of Wnt Signaling Pathway Endosomal Lumen Acidification Intracellular PH Reduction Golgi Lumen Acidification Synaptic Vesicle Lumen Acidification Proton Transmembrane Transport
Pathways			ROS and RNS production in phagocytes Neutrophil degranulation Insulin receptor recycling Transferrin endocytosis and recycling Amino acids regulate mTORC1 Ion channel transport Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy
Drugs			Tiludronic acid
Diseases
GWAS		Lymphocyte count ( 27863252 29403010 32888494) Lymphocyte percentage of white cells ( 27863252 32888494) Medication use (thyroid preparations) ( 31015401) Multiple sclerosis ( 24076602) Neutrophil percentage of white cells ( 27863252 32888494) Type 1 diabetes ( 19430480 25751624) White blood cell count ( 32888494)
Interacting Genes		14 interacting genes: ATP6V0C BRICD5 CLDN1 EBP MAL NINJ2 PMP22 RPRM SLC35B2 SMARCB1 STRIT1 TMEM190 TSPO2 UPK1B	54 interacting genes: AQP6 ARF6 ASGR2 CD53 CD69 CD79A CERS2 CLEC14A CLEC17A CLEC2D CLIC1 CPLX4 CREB3 DNAJC1 DRD2 EDA EDA2R ERBB2 ERGIC3 ERH EVI2A FAM210B FFAR2 GPR152 GPR25 GPR42 HSD17B13 HTR2C KLRC1 LMNA LRRC25 MARK3 MCEMP1 MDFI MSR1 NIPAL3 OPRM1 PDCD1LG2 PI16 PSMA3 RETREG3 SCN3B SLC35E3 SLC7A1 SMIM3 SPACA1 SSMEM1 STOM SUSD3 TMEM139 TMEM31 TMEM9 VSIR ZCCHC12
Entrez ID		969	527
HPRD ID		00119	00162
Ensembl ID		ENSG00000110848	ENSG00000185883
Uniprot IDs		Q07108 Q53ZX0	P27449
PDB IDs		1E87 1E8I 1FM5 3CCK 3HUP 8G94	6WLW 6WM2 6WM3 6WM4 7U4T 7UNF
Enriched GO Terms of Interacting Partners?		Membrane Protein Localization To Paranode Region Of Axon Cellular Developmental Process Protein Insertion Into Plasma Membrane Myelination Apical Plasma Membrane Axon Ensheathment Membrane Raft Polarization Hinge Region Between Urothelial Plaques Of Apical Plasma Membrane Membrane Destabilizing Activity Cholesterol Binding Compact Myelin Positive Regulation Of Glucose Mediated Signaling Pathway Germ Cell Nucleus Regulation Of Glucose Mediated Signaling Pathway Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Apical Plasma Membrane Urothelial Plaque Cellular Response To Butyrate Response To Butyrate Xenobiotic Transport Across Blood-nerve Barrier Cellular Response To Lead Ion Response To Interleukin-18 Establishment Of Blood-nerve Barrier Cholesterol Biosynthetic Process Via Lathosterol Cholesterol Biosynthetic Process Via Desmosterol C-8 Sterol Isomerase Activity Cholesterol-5,6-oxide Hydrolase Activity Steroid Delta-isomerase Activity Cholestenol Delta-isomerase Activity Inner Acrosomal Membrane 5-aminolevulinic Acid Import Across Plasma Membrane 5-aminolevulinic Acid Transmembrane Transporter Activity 3'-phosphoadenosine 5'-phosphosulfate Transport 5'-adenylyl Sulfate Transmembrane Transport 3'-phospho-5'-adenylyl Sulfate Transmembrane Transport 3'-phosphoadenosine 5'-phosphosulfate Transmembrane Transporter Activity Positive Regulation Of Calcium Ion Import Into Sarcoplasmic Reticulum Regulation Of Slow-twitch Skeletal Muscle Fiber Contraction Positive Regulation Of Cardiac Muscle Cell Contraction	Membrane Protein Binding Plasma Membrane Transmembrane Signaling Receptor Activity External Side Of Plasma Membrane Carbohydrate Binding G Protein-coupled Receptor Activity Fucose Binding Regulation Of Establishment Of Protein Localization Identical Protein Binding
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