ATP6V0C and DNAJC1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ATP6V0C	DNAJC1
Description		ATPase H+ transporting V0 subunit c	DnaJ heat shock protein family (Hsp40) member C1
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GO Annotations	Cellular Component	Golgi Membrane Vacuolar Proton-transporting V-type ATPase, V0 Domain Lysosomal Membrane Plasma Membrane Focal Adhesion Endosome Membrane Membrane Clathrin-coated Vesicle Membrane Phagocytic Vesicle Membrane Synaptic Vesicle Membrane Cytoplasmic Vesicle Proton-transporting V-type ATPase Complex Proton-transporting Two-sector ATPase Complex, Proton-transporting Domain Proton-transporting V-type ATPase, V0 Domain Azurophil Granule Membrane Synapse Extracellular Exosome Tertiary Granule Membrane Bounding Membrane Of Organelle Ficolin-1-rich Granule Membrane	Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Endomembrane System Membrane Nuclear Membrane
	Molecular Function	Protein Binding Proton Transmembrane Transporter Activity Ubiquitin Protein Ligase Binding Proton-transporting ATP Synthase Activity, Rotational Mechanism Proton-transporting ATPase Activity, Rotational Mechanism	ATPase Activator Activity DNA Binding Protein Binding Protein-folding Chaperone Binding
	Biological Process	Monoatomic Ion Transport Vacuolar Acidification Lysosomal Lumen Acidification Proton Motive Force-driven ATP Synthesis Regulation Of Macroautophagy Positive Regulation Of Wnt Signaling Pathway Endosomal Lumen Acidification Intracellular PH Reduction Golgi Lumen Acidification Synaptic Vesicle Lumen Acidification Proton Transmembrane Transport	Regulation Of Translation Protein Folding Negative Regulation Of Proteolysis Regulation Of Protein Secretion Regulation Of Protein Metabolic Process
Pathways		ROS and RNS production in phagocytes Neutrophil degranulation Insulin receptor recycling Transferrin endocytosis and recycling Amino acids regulate mTORC1 Ion channel transport Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy
Drugs		Tiludronic acid
Diseases
GWAS			Aspartate aminotransferase levels ( 33339817) Benign prostatic hyperplasia and lower urinary tract symptoms ( 30410027) Brain morphology (MOSTest) ( 32665545) Breast cancer ( 23535729 29059683) Breast cancer, ovarian cancer or prostate cancer (pleiotropy) ( 27432226) Essential hypertension (time to event) ( 32589924) Fish- and plant-related diet ( 32066663) Fruit consumption ( 32066663) Oily fish consumption ( 32066663) Ovarian cancer ( 23535730) Pork consumption ( 32066663) Raw vegetable consumption ( 32066663) Subcutaneous adipose tissue ( 26480920) Urinary albumin-to-creatinine ratio ( 31511532)
Interacting Genes		54 interacting genes: AQP6 ARF6 ASGR2 CD53 CD69 CD79A CERS2 CLEC14A CLEC17A CLEC2D CLIC1 CPLX4 CREB3 DNAJC1 DRD2 EDA EDA2R ERBB2 ERGIC3 ERH EVI2A FAM210B FFAR2 GPR152 GPR25 GPR42 HSD17B13 HTR2C KLRC1 LMNA LRRC25 MARK3 MCEMP1 MDFI MSR1 NIPAL3 OPRM1 PDCD1LG2 PI16 PSMA3 RETREG3 SCN3B SLC35E3 SLC7A1 SMIM3 SPACA1 SSMEM1 STOM SUSD3 TMEM139 TMEM31 TMEM9 VSIR ZCCHC12	12 interacting genes: ABHD16A AGTRAP ATP6V0C CFTR CMTM7 CYP4F2 HSPA5 ITIH4 PLP2 SERPINA3 TMEM201 TNFRSF10C
Entrez ID		527	64215
HPRD ID		00162	09922
Ensembl ID		ENSG00000185883	ENSG00000136770
Uniprot IDs		P27449	Q96KC8
PDB IDs		6WLW 6WM2 6WM3 6WM4 7U4T 7UNF	2CQQ 2CQR
Enriched GO Terms of Interacting Partners?		Membrane Protein Binding Plasma Membrane Transmembrane Signaling Receptor Activity External Side Of Plasma Membrane Carbohydrate Binding G Protein-coupled Receptor Activity Fucose Binding Regulation Of Establishment Of Protein Localization Identical Protein Binding	Multicellular Organismal-level Water Homeostasis Peptidase Inhibitor Activity Acute-phase Response Serine-type Endopeptidase Inhibitor Activity Acute Inflammatory Response Regulation Of Cellular PH Regulation Of PH Regulation Of Intracellular PH Membrane Protein-folding Chaperone Binding Endoplasmic Reticulum Endoplasmic Reticulum Membrane Positive Regulation Of Anion Channel Activity Positive Regulation Of Enamel Mineralization Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Multicellular Organismal-level Chemical Homeostasis Positive Regulation Of Monoatomic Anion Transport Cerebellum Structural Organization Regulation Of ATF6-mediated Unfolded Protein Response Regulation Of Protein Folding In Endoplasmic Reticulum Phosphatidylserine Catabolic Process Fatty Acid Derivative Metabolic Process Prostaglandin Catabolic Process Alpha-tocopherol Omega-hydroxylase Activity Negative Regulation Of Icosanoid Secretion Leukotriene B4 Catabolic Process 20-hydroxy-leukotriene B4 Omega Oxidase Activity Alkane 1-monooxygenase Activity 20-aldehyde-leukotriene B4 20-monooxygenase Activity Leukotriene B4 Metabolic Process Arachidonate Omega-hydroxylase Activity Leukotriene-B4 20-monooxygenase Activity Pressure Natriuresis Angiotensin Type II Receptor Activity B-1a B Cell Differentiation B-1 B Cell Differentiation Nuclear Migration Along Microtubule Blood Microparticle Proton-transporting Two-sector ATPase Complex, Proton-transporting Domain Transepithelial Water Transport Monoacylglycerol Catabolic Process Vitamin E Metabolic Process Menaquinone Catabolic Process TRAIL Binding Multicellular Organismal-level Homeostasis Monoatomic Ion Homeostasis Monoatomic Cation Homeostasis Positive Regulation Of Tooth Mineralization
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