ATP6V0C and ERH

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ATP6V0C	ERH
Description		ATPase H+ transporting V0 subunit c	ERH mRNA splicing and mitosis factor
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GO Annotations	Cellular Component	Golgi Membrane Vacuolar Proton-transporting V-type ATPase, V0 Domain Lysosomal Membrane Plasma Membrane Focal Adhesion Endosome Membrane Membrane Clathrin-coated Vesicle Membrane Phagocytic Vesicle Membrane Synaptic Vesicle Membrane Cytoplasmic Vesicle Proton-transporting V-type ATPase Complex Proton-transporting Two-sector ATPase Complex, Proton-transporting Domain Proton-transporting V-type ATPase, V0 Domain Azurophil Granule Membrane Synapse Extracellular Exosome Tertiary Granule Membrane Bounding Membrane Of Organelle Ficolin-1-rich Granule Membrane	Nucleus Midbody Methylosome
	Molecular Function	Protein Binding Proton Transmembrane Transporter Activity Ubiquitin Protein Ligase Binding Proton-transporting ATP Synthase Activity, Rotational Mechanism Proton-transporting ATPase Activity, Rotational Mechanism	RNA Binding Protein Binding Methyl-CpG Binding
	Biological Process	Monoatomic Ion Transport Vacuolar Acidification Lysosomal Lumen Acidification Proton Motive Force-driven ATP Synthesis Regulation Of Macroautophagy Positive Regulation Of Wnt Signaling Pathway Endosomal Lumen Acidification Intracellular PH Reduction Golgi Lumen Acidification Synaptic Vesicle Lumen Acidification Proton Transmembrane Transport	Nucleobase-containing Compound Metabolic Process Pyrimidine Nucleoside Metabolic Process
Pathways		ROS and RNS production in phagocytes Neutrophil degranulation Insulin receptor recycling Transferrin endocytosis and recycling Amino acids regulate mTORC1 Ion channel transport Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy
Drugs		Tiludronic acid
Diseases
GWAS			Lymphocyte percentage of white cells ( 32888494) Neutrophil percentage of white cells ( 32888494)
Interacting Genes		54 interacting genes: AQP6 ARF6 ASGR2 CD53 CD69 CD79A CERS2 CLEC14A CLEC17A CLEC2D CLIC1 CPLX4 CREB3 DNAJC1 DRD2 EDA EDA2R ERBB2 ERGIC3 ERH EVI2A FAM210B FFAR2 GPR152 GPR25 GPR42 HSD17B13 HTR2C KLRC1 LMNA LRRC25 MARK3 MCEMP1 MDFI MSR1 NIPAL3 OPRM1 PDCD1LG2 PI16 PSMA3 RETREG3 SCN3B SLC35E3 SLC7A1 SMIM3 SPACA1 SSMEM1 STOM SUSD3 TMEM139 TMEM31 TMEM9 VSIR ZCCHC12	26 interacting genes: APP ATP6V0C CENPH CIZ1 COPS6 CSNK2A1 CSNK2A2 CTDP1 CYSRT1 FNDC3B HSPA8 IFITM10 IGSF21 MED31 POLDIP3 PSMA6 RBM48 RPS6KA5 SETDB1 SH3GL2 TASOR2 TLE1 TP53 UNC119 UPRT WEE2-AS1
Entrez ID		527	2079
HPRD ID		00162	09026
Ensembl ID		ENSG00000185883	ENSG00000100632
Uniprot IDs		P27449	P84090
PDB IDs		6WLW 6WM2 6WM3 6WM4 7U4T 7UNF	1W9G 2NML 7CNC 7X39
Enriched GO Terms of Interacting Partners?		Membrane Protein Binding Plasma Membrane Transmembrane Signaling Receptor Activity External Side Of Plasma Membrane Carbohydrate Binding G Protein-coupled Receptor Activity Fucose Binding Regulation Of Establishment Of Protein Localization Identical Protein Binding	Regulation Of Protein Import Nucleoplasm Protein Kinase CK2 Complex Epigenetic Regulation Of Gene Expression Negative Regulation Of Gene Expression Regulation Of Macroautophagy Protein Targeting To Vacuole Involved In Autophagy
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