ATP6V0C and SSMEM1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ATP6V0C	SSMEM1
Description		ATPase H+ transporting V0 subunit c	serine rich single-pass membrane protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Vacuolar Proton-transporting V-type ATPase, V0 Domain Lysosomal Membrane Plasma Membrane Focal Adhesion Endosome Membrane Membrane Clathrin-coated Vesicle Membrane Phagocytic Vesicle Membrane Synaptic Vesicle Membrane Cytoplasmic Vesicle Proton-transporting V-type ATPase Complex Proton-transporting Two-sector ATPase Complex, Proton-transporting Domain Proton-transporting V-type ATPase, V0 Domain Azurophil Granule Membrane Synapse Extracellular Exosome Tertiary Granule Membrane Bounding Membrane Of Organelle Ficolin-1-rich Granule Membrane	Membrane
	Molecular Function	Protein Binding Proton Transmembrane Transporter Activity Ubiquitin Protein Ligase Binding Proton-transporting ATP Synthase Activity, Rotational Mechanism Proton-transporting ATPase Activity, Rotational Mechanism	Protein Binding
	Biological Process	Monoatomic Ion Transport Vacuolar Acidification Lysosomal Lumen Acidification Proton Motive Force-driven ATP Synthesis Regulation Of Macroautophagy Positive Regulation Of Wnt Signaling Pathway Endosomal Lumen Acidification Intracellular PH Reduction Golgi Lumen Acidification Synaptic Vesicle Lumen Acidification Proton Transmembrane Transport
Pathways		ROS and RNS production in phagocytes Neutrophil degranulation Insulin receptor recycling Transferrin endocytosis and recycling Amino acids regulate mTORC1 Ion channel transport Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy
Drugs		Tiludronic acid
Diseases
GWAS			Neurological blood protein biomarker levels ( 31320639)
Interacting Genes		54 interacting genes: AQP6 ARF6 ASGR2 CD53 CD69 CD79A CERS2 CLEC14A CLEC17A CLEC2D CLIC1 CPLX4 CREB3 DNAJC1 DRD2 EDA EDA2R ERBB2 ERGIC3 ERH EVI2A FAM210B FFAR2 GPR152 GPR25 GPR42 HSD17B13 HTR2C KLRC1 LMNA LRRC25 MARK3 MCEMP1 MDFI MSR1 NIPAL3 OPRM1 PDCD1LG2 PI16 PSMA3 RETREG3 SCN3B SLC35E3 SLC7A1 SMIM3 SPACA1 SSMEM1 STOM SUSD3 TMEM139 TMEM31 TMEM9 VSIR ZCCHC12	99 interacting genes: ALG3 APOA2 AQP1 AQP10 AQP3 ARLN ATP6V0C BET1 BLCAP C11orf24 C1QL4 C5 CCL4L2 CDIPT CDS2 CLRN2 CMTM7 CSGALNACT2 CTSA CXCL16 CXCL9 CYB561 CYBC1 DEFB103A DEFB103B DEFB121 EFNA5 EMD ERG28 ERMP1 FAM3C FATE1 FDPS FPR2 GJB2 GPHB5 GPR151 HMOX2 JAGN1 LAT LEPROTL1 LHFPL5 LNPEP MARCHF2 MCRS1 MFSD12 MFSD6 MIP MMD2 MS4A13 NINJ2 NIPAL4 NRM PGAP2 PLPP1 PLPP4 PLPP6 PLPPR2 RHD RTP2 RUSF1 S1PR5 SERP1 SLC35A1 SLC35E3 SLC35H1 SLC38A1 SLC38A7 SLC39A2 SLC39A9 SLC41A1 SLC41A2 SLC61A1 STX8 TAP1 TAS2R10 TLCD1 TM6SF2 TMEM128 TMEM14A TMEM14C TMEM203 TMEM218 TMEM222 TMEM239 TMEM243 TMEM45A TMEM60 TMEM86A TMEM86B TMEM97 TMPPE TNF TRARG1 UNC93B1 UPK1B VAMP4 YIPF6 ZFPL1
Entrez ID		527	136263
HPRD ID		00162	14060
Ensembl ID		ENSG00000185883	ENSG00000165120
Uniprot IDs		P27449	A0A3B3ISA2 Q8WWF3
PDB IDs		6WLW 6WM2 6WM3 6WM4 7U4T 7UNF
Enriched GO Terms of Interacting Partners?		Membrane Protein Binding Plasma Membrane Transmembrane Signaling Receptor Activity External Side Of Plasma Membrane Carbohydrate Binding G Protein-coupled Receptor Activity Fucose Binding Regulation Of Establishment Of Protein Localization Identical Protein Binding	Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Protein Binding Water Channel Activity Phosphatidate Phosphatase Activity Transmembrane Transport Glycerol Transmembrane Transport Carbohydrate Transport Water Transport Polyol Transmembrane Transport Phospholipid Metabolic Process Alkenylglycerophosphocholine Hydrolase Activity Fluid Transport Phospholipid Dephosphorylation Plasma Membrane Channel Activity Geranyl Diphosphate Metabolic Process Positive Regulation Of Neutrophil Activation Diacylglycerol Diphosphate Phosphatase Activity Magnesium Ion Transmembrane Transport Magnesium Ion Transmembrane Transporter Activity Magnesium Ion Transport Carbohydrate Transmembrane Transport Amide Transport Glycerol Channel Activity Lipid Phosphatase Activity Renal Water Absorption One-carbon Compound Transport Urea Transmembrane Transporter Activity Farnesyl Diphosphate Metabolic Process Gap Junction-mediated Intercellular Transport Sphingosine-1-phosphate Phosphatase Activity CCR6 Chemokine Receptor Binding Antigen Processing And Presentation Of Peptide Antigen Response To Bacterium Chemotaxis Lysophosphatidic Acid Phosphatase Activity Inorganic Cation Transmembrane Transporter Activity Renal Water Transport Neutrophil Differentiation Glutamine Transport L-glutamine Transmembrane Transporter Activity Locomotion Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Ammonium Channel Activity Urea Transmembrane Transport Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane
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