ATP6V0C and EVI2A

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		ATP6V0C	EVI2A
Name		ATPase H+ transporting V0 subunit c	ecotropic viral integration site 2A
Structure			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Vacuolar Proton-transporting V-type ATPase, V0 Domain Lysosomal Membrane Plasma Membrane Focal Adhesion Endosome Membrane Membrane Clathrin-coated Vesicle Membrane Phagocytic Vesicle Membrane Synaptic Vesicle Membrane Cytoplasmic Vesicle Proton-transporting V-type ATPase Complex Proton-transporting Two-sector ATPase Complex, Proton-transporting Domain Proton-transporting V-type ATPase, V0 Domain Azurophil Granule Membrane Synapse Extracellular Exosome Tertiary Granule Membrane Bounding Membrane Of Organelle Ficolin-1-rich Granule Membrane	Golgi Apparatus Cytosol Plasma Membrane Cilium Membrane
	Molecular Function	Protein Binding Proton Transmembrane Transporter Activity Ubiquitin Protein Ligase Binding Proton-transporting ATP Synthase Activity, Rotational Mechanism Proton-transporting ATPase Activity, Rotational Mechanism	Transmembrane Signaling Receptor Activity Protein Binding
	Biological Process	Monoatomic Ion Transport Vacuolar Acidification Lysosomal Lumen Acidification Proton Motive Force-driven ATP Synthesis Regulation Of Macroautophagy Positive Regulation Of Wnt Signaling Pathway Endosomal Lumen Acidification Intracellular PH Reduction Golgi Lumen Acidification Synaptic Vesicle Lumen Acidification Proton Transmembrane Transport	None
Pathways		ROS and RNS production in phagocytes Neutrophil degranulation Insulin receptor recycling Transferrin endocytosis and recycling Amino acids regulate mTORC1 Ion channel transport Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy	None
Drugs		Tiludronic acid	None
GWAS		No GWAS studies recorded	Brain morphology (MOSTest) ( 32665545 ) Endometrial cancer ( 30093612 ) Endometrial cancer (endometrioid histology) ( 30093612 )
Novel Interactors		None recorded	2 novel interactors: CRYBA1 DVL3
Interacting Genes		54 interacting genes: AQP6 ARF6 ASGR2 CD53 CD69 CD79A CERS2 CLEC14A CLEC17A CLEC2D CLIC1 CPLX4 CREB3 DNAJC1 DRD2 EDA EDA2R ERBB2 ERGIC3 ERH EVI2A FAM210B FFAR2 GPR152 GPR25 GPR42 HSD17B13 HTR2C KLRC1 LMNA LRRC25 MARK3 MCEMP1 MDFI MSR1 NIPAL3 OPRM1 PDCD1LG2 PI16 PSMA3 RETREG3 SCN3B SLC35E3 SLC7A1 SMIM3 SPACA1 SSMEM1 STOM SUSD3 TMEM139 TMEM31 TMEM9 VSIR ZCCHC12	10 interacting genes: APP ATP6V0C MAL MALL PLP2 PLPP4 RNF114 RORC RTP2 UBIAD1
Entrez ID		527	2123
HPRD ID		00162	08866
Ensembl ID		ENSG00000185883	ENSG00000126860
Uniprot IDs		P27449	P22794
PDB IDs		6WLW 6WM2 6WM3 6WM4 7U4T 7UNF	Not available
GO Terms Enriched among Interactors		Membrane Protein Binding Plasma Membrane Transmembrane Signaling Receptor Activity External Side Of Plasma Membrane Carbohydrate Binding G Protein-coupled Receptor Activity Fucose Binding Regulation Of Establishment Of Protein Localization Identical Protein Binding	Structural Constituent Of Myelin Sheath