ATP6V0C and CERS2

Number of citations of the paper that reports this interaction (PMID 11543633)
7

Data Source:
HPRD (in vivo, in vitro, two hybrid)

		ATP6V0C	CERS2
Gene Name		ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c	ceramide synthase 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Lysosomal Membrane Focal Adhesion Endosome Membrane Integral Component Of Membrane Phagocytic Vesicle Membrane Proton-transporting V-type ATPase, V0 Domain Extracellular Vesicular Exosome	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane Nuclear Membrane
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Binding Proton-transporting ATP Synthase Activity, Rotational Mechanism Proton-transporting ATPase Activity, Rotational Mechanism	DNA Binding Protein Binding Sphingosine N-acyltransferase Activity
	Biological Process	Cellular Iron Ion Homeostasis Insulin Receptor Signaling Pathway ATP Hydrolysis Coupled Proton Transport Proton Transport Viral Process Positive Regulation Of Wnt Signaling Pathway Transferrin Transport Interaction With Host Transmembrane Transport Phagosome Maturation	Sphingolipid Metabolic Process Sphingolipid Biosynthetic Process Small Molecule Metabolic Process Ceramide Biosynthetic Process
Pathways		Phagosomal maturation (early endosomal stage) Iron uptake and transport Latent infection of Homo sapiens with Mycobacterium tuberculosis Transferrin endocytosis and recycling Insulin receptor recycling Signaling by Insulin receptor	Sphingolipid metabolism Metabolism of lipids and lipoproteins Sphingolipid de novo biosynthesis
Drugs
Diseases
GWAS			Rhegmatogenous retinal detachment ( 23585552)
Protein-Protein Interactions		8 interactors: ARF6 CERS2 CLIC1 EDA MARK3 MSR1 PSMA3 SMIM3	9 interactors: ASGR1 ASGR2 ATP6V0C HSP90AA1 PEX6 SLC19A2 SLC22A1 SLC39A1 TMBIM6
Entrez ID		527	29956
HPRD ID		00162	06080
Ensembl ID		ENSG00000185883	ENSG00000143418
Uniprot IDs		P27449	Q96G23
PDB IDs
Enriched GO Terms of Interacting Partners?			Transmembrane Transport Transport Drug Transmembrane Transport Drug Transport Intracellular Protein Transmembrane Transport Protein Transmembrane Transport Receptor-mediated Endocytosis Epinephrine Transport Response To Unfolded Protein Protein Import Into Peroxisome Matrix, Translocation Acetate Ester Transport Establishment Or Maintenance Of Transmembrane Electrochemical Gradient Regulation Of Protein Stability Protein Import Into Mitochondrial Outer Membrane Norepinephrine Transport Protein Import Endocytosis Thiamine Transmembrane Transport Thiamine Transport Thiamine-containing Compound Metabolic Process Ion Transport Folic Acid Transport Chemical Homeostasis Dopamine Transport Cation Transmembrane Transport Chaperone-mediated Protein Complex Assembly Protein Import Into Peroxisome Matrix Pyrimidine-containing Compound Transmembrane Transport Quaternary Ammonium Group Transport Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Establishment Of Protein Localization To Organelle Protein Refolding Vitamin Transmembrane Transport Cation Transport Zinc Ion Transmembrane Transport Cellular Metal Ion Homeostasis Monoamine Transport Protein Targeting To Peroxisome Establishment Of Protein Localization To Peroxisome Response To Stimulus Protein Targeting Ion Transmembrane Transport Nitric Oxide Metabolic Process Endoplasmic Reticulum Calcium Ion Homeostasis Cellular Cation Homeostasis Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Regulation Of Cellular Response To Heat Cellular Ion Homeostasis Reactive Nitrogen Species Metabolic Process Posttranscriptional Regulation Of Gene Expression See more
Tagcloud ?		a1 accumulate acidification alp autophagic autophagy bafilomycin critically dead flux iodide knockdown lamp lc3 lysosomal lysosome lysostracker neurite neuroblastoma neurodegenerative nucleofected propidium sensitized sh substrates sy5y synuclein vacuolar vesicular	17beta ceramide ceramides cers4 cers5 cers6 clarify constructs dimerization erbeta estradiol fos fulvestrant fumonisin gper1 investigating lengths luc luciferase mcf pathophysiological plasmids posttranscriptional processess promoters sphingolipid synthases utr
Tagcloud (Difference) ?		a1 accumulate acidification alp autophagic autophagy bafilomycin critically dead flux iodide knockdown lamp lc3 lysosomal lysosome lysostracker neurite neuroblastoma neurodegenerative nucleofected propidium sensitized sh substrates sy5y synuclein vacuolar vesicular	17beta ceramide ceramides cers4 cers5 cers6 clarify constructs dimerization erbeta estradiol fos fulvestrant fumonisin gper1 investigating lengths luc luciferase mcf pathophysiological plasmids posttranscriptional processess promoters sphingolipid synthases utr
Tagcloud (Intersection) ?