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HIST1H4A and PBRM1
Number of citations of the paper that reports this interaction (PMID
20368734
)
7
Data Source:
BioGRID
(unspecified method)
HIST1H4A
PBRM1
Gene Name
histone cluster 1, H4a
polybromo 1
Image
Gene Ontology Annotations
Cellular Component
Nuclear Chromosome
Nucleosome
Extracellular Region
Nucleus
Nucleoplasm
Membrane
Protein Complex
Extracellular Vesicular Exosome
Nuclear Chromosome
Kinetochore
Molecular Function
DNA Binding
Protein Binding
Histone Demethylase Activity (H4-K20 Specific)
Poly(A) RNA Binding
Protein Heterodimerization Activity
DNA Binding
Chromatin Binding
Protein Binding
Biological Process
Chromatin Silencing At RDNA
Mitotic Cell Cycle
Telomere Maintenance
Chromatin Organization
Nucleosome Assembly
DNA Replication-dependent Nucleosome Assembly
DNA Replication-independent Nucleosome Assembly
Gene Expression
DNA Methylation On Cytosine
CENP-A Containing Nucleosome Assembly
Histone H4-K20 Demethylation
Regulation Of Gene Expression, Epigenetic
Negative Regulation Of Megakaryocyte Differentiation
Negative Regulation Of Gene Expression, Epigenetic
Placenta Development
Chromatin Remodeling
Transcription, DNA-templated
Regulation Of Transcription, DNA-templated
Mitotic Nuclear Division
Heart Development
Negative Regulation Of Cell Proliferation
Pathways
RNA Polymerase I Chain Elongation
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
Mitotic Prophase
PKMTs methylate histone lysines
Regulatory RNA pathways
RNA Polymerase I Promoter Clearance
Deposition of new CENPA-containing nucleosomes at the centromere
HDMs demethylate histones
Cellular Senescence
Signaling by Wnt
HATs acetylate histones
M Phase
Amyloids
NoRC negatively regulates rRNA expression
Packaging Of Telomere Ends
Telomere Maintenance
Nucleosome assembly
RNF mutants show enhanced WNT signaling and proliferation
XAV939 inhibits tankyrase, stabilizing AXIN
DNA methylation
Transcriptional regulation by small RNAs
Meiotic recombination
DNA Damage/Telomere Stress Induced Senescence
Chromosome Maintenance
HDACs deacetylate histones
Chromatin organization
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
RNA Polymerase I Transcription
formation of the beta-catenin:TCF transactivating complex
Meiotic synapsis
Epigenetic regulation of gene expression
Senescence-Associated Secretory Phenotype (SASP)
Negative epigenetic regulation of rRNA expression
PRC2 methylates histones and DNA
Cell Cycle, Mitotic
RMTs methylate histone arginines
Chromatin modifying enzymes
Oxidative Stress Induced Senescence
TCF dependent signaling in response to WNT
RNA Polymerase I Promoter Opening
SIRT1 negatively regulates rRNA Expression
Signaling by WNT in cancer
Condensation of Prophase Chromosomes
Chromatin modifying enzymes
Chromatin organization
RMTs methylate histone arginines
Drugs
Diseases
GWAS
HIV-1 viral setpoint (
22174851
)
Bipolar disorder (
21926972
)
Bipolar disorder (mood-incongruent) (
23092984
)
Major mood disorders (
20081856
)
Protein-Protein Interactions
73 interactors:
ANP32A
BAZ1B
BAZ2A
BLOC1S1
BRD2
CALCOCO1
CBX3
CDK1
CDK2
COPS2
CREBBP
CTDP1
DYRK1A
EID1
ELP3
EP300
ERCC6
GATAD2A
GATAD2B
HAT1
HDAC1
HDAC2
HDAC3
HDAC8
HIRIP3
HIST1H3A
HIST2H2AC
HIST2H2BE
HJURP
KAT2A
KAT2B
KAT5
KAT6A
KAT7
KAT8
KDM4A
KMT2A
L3MBTL2
MSL2
MSL3
NASP
NCOR1
NCOR2
NPM1
NR1H4
PAK1
PARP1
PARP10
PBRM1
PELP1
PHF20
PHF8
PRMT1
PRMT5
PRMT7
PRMT8
PTMA
RCC1
SETD7
SIRT7
SSRP1
SUV420H1
SUV420H2
TAF1
TAF1A
TAF1B
TBL1X
THAP7
TP53BP1
UBC
UBE2I
UCHL5
YY1
9 interactors:
APP
HIST1H3A
HIST1H4A
HIST2H2AC
HIST2H2BE
PTS
SMARCA4
ZDHHC17
ZNF512B
Entrez ID
8359
55193
HPRD ID
04157
07302
Ensembl ID
ENSG00000196176
ENSG00000163939
Uniprot IDs
B2R4R0
P62805
Q86U86
PDB IDs
2BQZ
2CV5
2KWN
2KWO
2LVM
2QQS
2RNY
2RS9
3A6N
3AFA
3AN2
3AV1
3AV2
3AYW
3AZE
3AZF
3AZG
3AZH
3AZI
3AZJ
3AZK
3AZL
3AZM
3AZN
3CFS
3CFV
3F9W
3F9X
3F9Y
3F9Z
3NQJ
3NQU
3O36
3QZS
3QZT
3QZV
3R45
3UVW
3UVX
3UVY
3UW9
3W96
3W97
3W98
3W99
4GQB
4H9N
4H9O
4H9P
4H9Q
4H9R
4H9S
4HGA
2KTB
3G0J
3HMF
3IU5
3IU6
3K2J
3LJW
3MB4
3TLP
Enriched GO Terms of Interacting Partners
?
Chromatin Organization
Chromatin Modification
Chromosome Organization
Histone Modification
Transcription, DNA-templated
RNA Biosynthetic Process
Regulation Of RNA Metabolic Process
Regulation Of RNA Biosynthetic Process
Cellular Macromolecule Biosynthetic Process
Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Macromolecule Biosynthetic Process
Regulation Of Gene Expression
Regulation Of Nitrogen Compound Metabolic Process
Organelle Organization
RNA Metabolic Process
Gene Expression
Nucleobase-containing Compound Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Biosynthetic Process
Nitrogen Compound Metabolic Process
Peptidyl-lysine Modification
Regulation Of Metabolic Process
Peptidyl-lysine Acetylation
Peptidyl-amino Acid Modification
Protein Acetylation
Negative Regulation Of Transcription, DNA-templated
Negative Regulation Of Nucleic Acid-templated Transcription
Histone Acetylation
Negative Regulation Of RNA Biosynthetic Process
Internal Peptidyl-lysine Acetylation
Cellular Protein Modification Process
Internal Protein Amino Acid Acetylation
Negative Regulation Of Gene Expression
Cellular Metabolic Process
Negative Regulation Of Biosynthetic Process
Negative Regulation Of Cellular Metabolic Process
Positive Regulation Of Gene Expression
Histone H4 Acetylation
Cellular Protein Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Regulation Of Transcription From RNA Polymerase II Promoter
Positive Regulation Of Cellular Biosynthetic Process
Chromatin Remodeling
Chromatin Assembly Or Disassembly
Regulation Of Cellular Process
Positive Regulation Of Transcription, DNA-templated
Transcription From RNA Polymerase II Promoter
DNA Methylation On Cytosine
Nucleosome Organization
Chromatin Assembly Or Disassembly
Chromatin Silencing
DNA Methylation
Negative Regulation Of Gene Expression, Epigenetic
DNA Modification
DNA Replication-dependent Nucleosome Assembly
Gene Silencing
Nucleosome Assembly
Chromatin Assembly
Chromatin Silencing At RDNA
Protein-DNA Complex Assembly
DNA Packaging
Regulation Of Gene Expression, Epigenetic
Chromatin Organization
DNA Conformation Change
ATP-dependent Chromatin Remodeling
Chromosome Organization
Methylation
Negative Regulation Of Transcription From RNA Polymerase II Promoter During Mitosis
Synaptic Growth At Neuromuscular Junction
Collateral Sprouting In Absence Of Injury
Histone H4-K20 Demethylation
Cellular Macromolecular Complex Assembly
DNA Methylation On Cytosine Within A CG Sequence
Negative Regulation Of Megakaryocyte Differentiation
Collateral Sprouting
Axon Midline Choice Point Recognition
Chromatin Remodeling
Negative Regulation Of Cell Differentiation
Smooth Endoplasmic Reticulum Calcium Ion Homeostasis
Definitive Erythrocyte Differentiation
Aortic Smooth Muscle Cell Differentiation
Axon Choice Point Recognition
Tetrahydrobiopterin Biosynthetic Process
Glial Cell Fate Determination
Methylation-dependent Chromatin Silencing
Regulation Of Mitotic Cell Cycle Phase Transition
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Regulation Of Cell Cycle Phase Transition
Negative Regulation Of Hematopoietic Progenitor Cell Differentiation
Neuron Remodeling
Cellular Component Assembly
Positive Regulation By Host Of Viral Transcription
Cellular Nitrogen Compound Metabolic Process
Regulation Of Binding
Central Nervous System Development
Developmental Growth
Tagcloud
?
1000x
abstracted
arid1a
bap1
cca
cdkn2a
cholangiocarcinoma
entities
extrahepatic
fbxw7
fgfr
gas
hiseq
hotspot
idh1
illumina
indolent
intrahepatic
introns
kras
mcl1
ngs
pgm
presentations
radiologic
sequencer
smad4
targetable
worse
Tagcloud (Difference)
?
1000x
abstracted
arid1a
bap1
cca
cdkn2a
cholangiocarcinoma
entities
extrahepatic
fbxw7
fgfr
gas
hiseq
hotspot
idh1
illumina
indolent
intrahepatic
introns
kras
mcl1
ngs
pgm
presentations
radiologic
sequencer
smad4
targetable
worse
Tagcloud (Intersection)
?