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HIST1H4A and PHF8
Number of citations of the paper that reports this interaction (PMID
20622853
)
50
Data Source:
BioGRID
(enzymatic study)
HIST1H4A
PHF8
Gene Name
histone cluster 1, H4a
PHD finger protein 8
Image
Gene Ontology Annotations
Cellular Component
Nuclear Chromosome
Nucleosome
Extracellular Region
Nucleus
Nucleoplasm
Membrane
Protein Complex
Extracellular Vesicular Exosome
Nucleus
Nucleoplasm
Nucleolus
Nuclear Membrane
Molecular Function
DNA Binding
Protein Binding
Histone Demethylase Activity (H4-K20 Specific)
Poly(A) RNA Binding
Protein Heterodimerization Activity
Chromatin Binding
Iron Ion Binding
Protein Binding
Zinc Ion Binding
Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, 2-oxoglutarate As One Donor, And Incorporation Of One Atom Each Of Oxygen Into Both Donors
Histone Demethylase Activity
Histone Demethylase Activity (H3-K9 Specific)
Methylated Histone Binding
Histone Demethylase Activity (H4-K20 Specific)
Histone Demethylase Activity (H3-K36 Specific)
Histone Demethylase Activity (H3-K27 Specific)
Biological Process
Chromatin Silencing At RDNA
Mitotic Cell Cycle
Telomere Maintenance
Chromatin Organization
Nucleosome Assembly
DNA Replication-dependent Nucleosome Assembly
DNA Replication-independent Nucleosome Assembly
Gene Expression
DNA Methylation On Cytosine
CENP-A Containing Nucleosome Assembly
Histone H4-K20 Demethylation
Regulation Of Gene Expression, Epigenetic
Negative Regulation Of Megakaryocyte Differentiation
Negative Regulation Of Gene Expression, Epigenetic
G1/S Transition Of Mitotic Cell Cycle
Mitotic Cell Cycle
Chromatin Organization
Transcription, DNA-templated
Brain Development
Histone H3-K9 Demethylation
Histone H4-K20 Demethylation
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription From RNA Polymerase I Promoter
Oxidation-reduction Process
Negative Regulation Of Chromatin Silencing At RDNA
Histone H3-K36 Demethylation
Histone H3-K27 Demethylation
Pathways
RNA Polymerase I Chain Elongation
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
Mitotic Prophase
PKMTs methylate histone lysines
Regulatory RNA pathways
RNA Polymerase I Promoter Clearance
Deposition of new CENPA-containing nucleosomes at the centromere
HDMs demethylate histones
Cellular Senescence
Signaling by Wnt
HATs acetylate histones
M Phase
Amyloids
NoRC negatively regulates rRNA expression
Packaging Of Telomere Ends
Telomere Maintenance
Nucleosome assembly
RNF mutants show enhanced WNT signaling and proliferation
XAV939 inhibits tankyrase, stabilizing AXIN
DNA methylation
Transcriptional regulation by small RNAs
Meiotic recombination
DNA Damage/Telomere Stress Induced Senescence
Chromosome Maintenance
HDACs deacetylate histones
Chromatin organization
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
RNA Polymerase I Transcription
formation of the beta-catenin:TCF transactivating complex
Meiotic synapsis
Epigenetic regulation of gene expression
Senescence-Associated Secretory Phenotype (SASP)
Negative epigenetic regulation of rRNA expression
PRC2 methylates histones and DNA
Cell Cycle, Mitotic
RMTs methylate histone arginines
Chromatin modifying enzymes
Oxidative Stress Induced Senescence
TCF dependent signaling in response to WNT
RNA Polymerase I Promoter Opening
SIRT1 negatively regulates rRNA Expression
Signaling by WNT in cancer
Condensation of Prophase Chromosomes
Chromatin modifying enzymes
Chromatin organization
HDMs demethylate histones
Drugs
Diseases
GWAS
HIV-1 viral setpoint (
22174851
)
Bipolar disorder and schizophrenia (
21057379
)
Protein-Protein Interactions
73 interactors:
ANP32A
BAZ1B
BAZ2A
BLOC1S1
BRD2
CALCOCO1
CBX3
CDK1
CDK2
COPS2
CREBBP
CTDP1
DYRK1A
EID1
ELP3
EP300
ERCC6
GATAD2A
GATAD2B
HAT1
HDAC1
HDAC2
HDAC3
HDAC8
HIRIP3
HIST1H3A
HIST2H2AC
HIST2H2BE
HJURP
KAT2A
KAT2B
KAT5
KAT6A
KAT7
KAT8
KDM4A
KMT2A
L3MBTL2
MSL2
MSL3
NASP
NCOR1
NCOR2
NPM1
NR1H4
PAK1
PARP1
PARP10
PBRM1
PELP1
PHF20
PHF8
PRMT1
PRMT5
PRMT7
PRMT8
PTMA
RCC1
SETD7
SIRT7
SSRP1
SUV420H1
SUV420H2
TAF1
TAF1A
TAF1B
TBL1X
THAP7
TP53BP1
UBC
UBE2I
UCHL5
YY1
6 interactors:
APP
HIST1H3A
HIST1H4A
HIST3H3
POLR2A
RARA
Entrez ID
8359
23133
HPRD ID
04157
06599
Ensembl ID
ENSG00000196176
ENSG00000172943
Uniprot IDs
B2R4R0
P62805
O95327
Q9UPP1
PDB IDs
2BQZ
2CV5
2KWN
2KWO
2LVM
2QQS
2RNY
2RS9
3A6N
3AFA
3AN2
3AV1
3AV2
3AYW
3AZE
3AZF
3AZG
3AZH
3AZI
3AZJ
3AZK
3AZL
3AZM
3AZN
3CFS
3CFV
3F9W
3F9X
3F9Y
3F9Z
3NQJ
3NQU
3O36
3QZS
3QZT
3QZV
3R45
3UVW
3UVX
3UVY
3UW9
3W96
3W97
3W98
3W99
4GQB
4H9N
4H9O
4H9P
4H9Q
4H9R
4H9S
4HGA
2WWU
3K3N
3K3O
3KV4
4DO0
Enriched GO Terms of Interacting Partners
?
Chromatin Organization
Chromatin Modification
Chromosome Organization
Histone Modification
Transcription, DNA-templated
RNA Biosynthetic Process
Regulation Of RNA Metabolic Process
Regulation Of RNA Biosynthetic Process
Cellular Macromolecule Biosynthetic Process
Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Macromolecule Biosynthetic Process
Regulation Of Gene Expression
Regulation Of Nitrogen Compound Metabolic Process
Organelle Organization
RNA Metabolic Process
Gene Expression
Nucleobase-containing Compound Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Biosynthetic Process
Nitrogen Compound Metabolic Process
Peptidyl-lysine Modification
Regulation Of Metabolic Process
Peptidyl-lysine Acetylation
Peptidyl-amino Acid Modification
Protein Acetylation
Negative Regulation Of Transcription, DNA-templated
Negative Regulation Of Nucleic Acid-templated Transcription
Histone Acetylation
Negative Regulation Of RNA Biosynthetic Process
Internal Peptidyl-lysine Acetylation
Cellular Protein Modification Process
Internal Protein Amino Acid Acetylation
Negative Regulation Of Gene Expression
Cellular Metabolic Process
Negative Regulation Of Biosynthetic Process
Negative Regulation Of Cellular Metabolic Process
Positive Regulation Of Gene Expression
Histone H4 Acetylation
Cellular Protein Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Regulation Of Transcription From RNA Polymerase II Promoter
Positive Regulation Of Cellular Biosynthetic Process
Chromatin Remodeling
Chromatin Assembly Or Disassembly
Regulation Of Cellular Process
Positive Regulation Of Transcription, DNA-templated
Transcription From RNA Polymerase II Promoter
DNA Replication-dependent Nucleosome Assembly
DNA Methylation On Cytosine
Chromatin Silencing At RDNA
Negative Regulation Of Cell Differentiation
Chromatin Silencing
Nucleobase-containing Compound Metabolic Process
DNA Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Cellular Nitrogen Compound Metabolic Process
DNA Methylation
Negative Regulation Of Gene Expression, Epigenetic
Telomere Maintenance
Nitrogen Compound Metabolic Process
Negative Regulation Of Myeloid Cell Differentiation
DNA Modification
Sertoli Cell Fate Commitment
Regulation Of Cell Differentiation
Gene Silencing
Gene Expression
Nucleosome Assembly
Chromatin Assembly
Transcription, RNA-templated
Synaptic Growth At Neuromuscular Junction
Nucleosome Organization
Developmental Growth Involved In Morphogenesis
Chromatin Assembly Or Disassembly
Protein-DNA Complex Assembly
Collateral Sprouting In Absence Of Injury
Histone H4-K20 Demethylation
Transcription Initiation From RNA Polymerase II Promoter
Regulation Of Myeloid Cell Differentiation
Negative Regulation Of Cellular Metabolic Process
DNA Packaging
Chondroblast Differentiation
Regulation Of Transcription, DNA-templated
Intracellular Receptor Signaling Pathway
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of Gene Expression, Epigenetic
Negative Regulation Of Megakaryocyte Differentiation
Collateral Sprouting
Axon Midline Choice Point Recognition
Regulation Of RNA Metabolic Process
DNA-templated Transcription, Initiation
Smooth Endoplasmic Reticulum Calcium Ion Homeostasis
Chromosome Organization
Axon Choice Point Recognition
Regulation Of Binding
Negative Regulation Of Transcription, DNA-templated
Tagcloud
?
assaying
astrocytes
cd11b
cns
demethylases
demethylation
fcm
fixative
gfap
h3k27
jhdm1d
jmjd1c
jmjd2d
jmjd3
jmjd5
jumonji
lowest
messenger
microglia
multiparametric
mzbf
neun
optimized
profiled
simultaneously
sort
sorted
transcriptionally
utx
Tagcloud (Difference)
?
assaying
astrocytes
cd11b
cns
demethylases
demethylation
fcm
fixative
gfap
h3k27
jhdm1d
jmjd1c
jmjd2d
jmjd3
jmjd5
jumonji
lowest
messenger
microglia
multiparametric
mzbf
neun
optimized
profiled
simultaneously
sort
sorted
transcriptionally
utx
Tagcloud (Intersection)
?