Wiki-Pi
Answer Survey
Home
About
Help
Advanced Search
HIST1H4A and HDAC3
Number of citations of the paper that reports this interaction (PMID
15832170
)
26
Data Source:
BioGRID
(enzymatic study)
HIST1H4A
HDAC3
Gene Name
histone cluster 1, H4a
histone deacetylase 3
Image
Gene Ontology Annotations
Cellular Component
Nuclear Chromosome
Nucleosome
Extracellular Region
Nucleus
Nucleoplasm
Membrane
Protein Complex
Extracellular Vesicular Exosome
Histone Deacetylase Complex
Nucleus
Nucleoplasm
Cytoplasm
Golgi Apparatus
Spindle Microtubule
Plasma Membrane
Transcriptional Repressor Complex
Molecular Function
DNA Binding
Protein Binding
Histone Demethylase Activity (H4-K20 Specific)
Poly(A) RNA Binding
Protein Heterodimerization Activity
Chromatin Binding
Transcription Corepressor Activity
Histone Deacetylase Activity
Protein Binding
Transcription Factor Binding
Enzyme Binding
Cyclin Binding
Chromatin DNA Binding
NAD-dependent Histone Deacetylase Activity (H3-K14 Specific)
Protein Deacetylase Activity
Histone Deacetylase Binding
NAD-dependent Histone Deacetylase Activity (H3-K9 Specific)
NAD-dependent Histone Deacetylase Activity (H4-K16 Specific)
NAD-dependent Histone Deacetylase Activity (H3-K18 Specific)
Biological Process
Chromatin Silencing At RDNA
Mitotic Cell Cycle
Telomere Maintenance
Chromatin Organization
Nucleosome Assembly
DNA Replication-dependent Nucleosome Assembly
DNA Replication-independent Nucleosome Assembly
Gene Expression
DNA Methylation On Cytosine
CENP-A Containing Nucleosome Assembly
Histone H4-K20 Demethylation
Regulation Of Gene Expression, Epigenetic
Negative Regulation Of Megakaryocyte Differentiation
Negative Regulation Of Gene Expression, Epigenetic
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Positive Regulation Of Protein Phosphorylation
Chromatin Organization
Transcription, DNA-templated
Protein Deacetylation
Notch Signaling Pathway
Regulation Of Mitotic Cell Cycle
Circadian Rhythm
Negative Regulation Of Myotube Differentiation
Chromatin Modification
Regulation Of Protein Stability
Positive Regulation Of TOR Signaling
Circadian Regulation Of Gene Expression
Regulation Of Multicellular Organism Growth
Positive Regulation Of Transcription Factor Import Into Nucleus
Negative Regulation Of Apoptotic Process
Cellular Lipid Metabolic Process
Small Molecule Metabolic Process
Negative Regulation Of Cell Cycle
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Negative Regulation Of JNK Cascade
Neurotrophin TRK Receptor Signaling Pathway
Spindle Assembly
Histone H3-K9 Modification
Histone H3 Deacetylation
Histone H4 Deacetylation
Cellular Response To Fluid Shear Stress
Pathways
RNA Polymerase I Chain Elongation
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
Mitotic Prophase
PKMTs methylate histone lysines
Regulatory RNA pathways
RNA Polymerase I Promoter Clearance
Deposition of new CENPA-containing nucleosomes at the centromere
HDMs demethylate histones
Cellular Senescence
Signaling by Wnt
HATs acetylate histones
M Phase
Amyloids
NoRC negatively regulates rRNA expression
Packaging Of Telomere Ends
Telomere Maintenance
Nucleosome assembly
RNF mutants show enhanced WNT signaling and proliferation
XAV939 inhibits tankyrase, stabilizing AXIN
DNA methylation
Transcriptional regulation by small RNAs
Meiotic recombination
DNA Damage/Telomere Stress Induced Senescence
Chromosome Maintenance
HDACs deacetylate histones
Chromatin organization
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
RNA Polymerase I Transcription
formation of the beta-catenin:TCF transactivating complex
Meiotic synapsis
Epigenetic regulation of gene expression
Senescence-Associated Secretory Phenotype (SASP)
Negative epigenetic regulation of rRNA expression
PRC2 methylates histones and DNA
Cell Cycle, Mitotic
RMTs methylate histone arginines
Chromatin modifying enzymes
Oxidative Stress Induced Senescence
TCF dependent signaling in response to WNT
RNA Polymerase I Promoter Opening
SIRT1 negatively regulates rRNA Expression
Signaling by WNT in cancer
Condensation of Prophase Chromosomes
Signaling by NOTCH1 HD Domain Mutants in Cancer
PPARA activates gene expression
Organelle biogenesis and maintenance
Metabolism of lipids and lipoproteins
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
RORA activates circadian gene expression
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
Signaling by NOTCH1
Transcriptional regulation of white adipocyte differentiation
Signaling by NOTCH1 in Cancer
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
FBXW7 Mutants and NOTCH1 in Cancer
Signalling by NGF
Fatty acid, triacylglycerol, and ketone body metabolism
Chromatin organization
p75NTR negatively regulates cell cycle via SC1
HDACs deacetylate histones
Signaling by NOTCH
p75 NTR receptor-mediated signalling
REV-ERBA represses gene expression
Mitochondrial biogenesis
NOTCH1 Intracellular Domain Regulates Transcription
Chromatin modifying enzymes
Signaling by NOTCH1 PEST Domain Mutants in Cancer
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Transcriptional activation of mitochondrial biogenesis
Constitutive Signaling by NOTCH1 PEST Domain Mutants
BMAL1:CLOCK,NPAS2 activates circadian gene expression
Drugs
Diseases
GWAS
HIV-1 viral setpoint (
22174851
)
Protein-Protein Interactions
73 interactors:
ANP32A
BAZ1B
BAZ2A
BLOC1S1
BRD2
CALCOCO1
CBX3
CDK1
CDK2
COPS2
CREBBP
CTDP1
DYRK1A
EID1
ELP3
EP300
ERCC6
GATAD2A
GATAD2B
HAT1
HDAC1
HDAC2
HDAC3
HDAC8
HIRIP3
HIST1H3A
HIST2H2AC
HIST2H2BE
HJURP
KAT2A
KAT2B
KAT5
KAT6A
KAT7
KAT8
KDM4A
KMT2A
L3MBTL2
MSL2
MSL3
NASP
NCOR1
NCOR2
NPM1
NR1H4
PAK1
PARP1
PARP10
PBRM1
PELP1
PHF20
PHF8
PRMT1
PRMT5
PRMT7
PRMT8
PTMA
RCC1
SETD7
SIRT7
SSRP1
SUV420H1
SUV420H2
TAF1
TAF1A
TAF1B
TBL1X
THAP7
TP53BP1
UBC
UBE2I
UCHL5
YY1
96 interactors:
ANKRD11
ANKRD12
AR
ARID4A
ATF3
BCL3
BCOR
BRINP1
BRMS1
CBFA2T3
CCND1
CCT5
CEBPD
CORO2A
CREB3
CREBBP
CSNK2A1
CTBP1
DAXX
DHX30
EED
EP300
EWSR1
GATA1
GATA2
GCM1
GPS2
GTF2I
GTF2IRD1
HDAC1
HDAC10
HDAC4
HDAC5
HDAC7
HDAC9
HIF1AN
HIST1H4A
HNF4A
HR
HSPA4
HSPA8
IL16
JUN
KLF6
LCOR
MAPK11
MAPK14
MBD1
NACC1
NCOR1
NCOR2
NFKBIA
NR0B2
NR2C1
NR2E3
NRIP1
PARP1
PHB2
PIAS2
PML
PPARD
PPARG
PPP4C
PPP4R1
PRKDC
RARA
RB1
RBBP4
RELA
RUNX1
RUNX1T1
RUNX2
RXRA
SMYD1
SRC
SREBF2
SRY
STAT3
SUV39H1
SYK
TAB2
TBL1X
TBL1XR1
THAP11
THAP7
THRA
THRB
TMPO
TNFRSF14
TP53
TXNIP
VHL
WISP2
XPO1
YY1
ZBTB16
Entrez ID
8359
8841
HPRD ID
04157
08950
Ensembl ID
ENSG00000196176
ENSG00000171720
Uniprot IDs
B2R4R0
P62805
O15379
PDB IDs
2BQZ
2CV5
2KWN
2KWO
2LVM
2QQS
2RNY
2RS9
3A6N
3AFA
3AN2
3AV1
3AV2
3AYW
3AZE
3AZF
3AZG
3AZH
3AZI
3AZJ
3AZK
3AZL
3AZM
3AZN
3CFS
3CFV
3F9W
3F9X
3F9Y
3F9Z
3NQJ
3NQU
3O36
3QZS
3QZT
3QZV
3R45
3UVW
3UVX
3UVY
3UW9
3W96
3W97
3W98
3W99
4GQB
4H9N
4H9O
4H9P
4H9Q
4H9R
4H9S
4HGA
4A69
Enriched GO Terms of Interacting Partners
?
Chromatin Organization
Chromatin Modification
Chromosome Organization
Histone Modification
Transcription, DNA-templated
RNA Biosynthetic Process
Regulation Of RNA Metabolic Process
Regulation Of RNA Biosynthetic Process
Cellular Macromolecule Biosynthetic Process
Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Macromolecule Biosynthetic Process
Regulation Of Gene Expression
Regulation Of Nitrogen Compound Metabolic Process
Organelle Organization
RNA Metabolic Process
Gene Expression
Nucleobase-containing Compound Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Biosynthetic Process
Nitrogen Compound Metabolic Process
Peptidyl-lysine Modification
Regulation Of Metabolic Process
Peptidyl-lysine Acetylation
Peptidyl-amino Acid Modification
Protein Acetylation
Negative Regulation Of Transcription, DNA-templated
Negative Regulation Of Nucleic Acid-templated Transcription
Histone Acetylation
Negative Regulation Of RNA Biosynthetic Process
Internal Peptidyl-lysine Acetylation
Cellular Protein Modification Process
Internal Protein Amino Acid Acetylation
Negative Regulation Of Gene Expression
Cellular Metabolic Process
Negative Regulation Of Biosynthetic Process
Negative Regulation Of Cellular Metabolic Process
Positive Regulation Of Gene Expression
Histone H4 Acetylation
Cellular Protein Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Regulation Of Transcription From RNA Polymerase II Promoter
Positive Regulation Of Cellular Biosynthetic Process
Chromatin Remodeling
Chromatin Assembly Or Disassembly
Regulation Of Cellular Process
Positive Regulation Of Transcription, DNA-templated
Transcription From RNA Polymerase II Promoter
Negative Regulation Of Transcription, DNA-templated
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Transcription, DNA-templated
RNA Biosynthetic Process
Negative Regulation Of Gene Expression
Negative Regulation Of Biosynthetic Process
Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of RNA Metabolic Process
Regulation Of Nitrogen Compound Metabolic Process
Gene Expression
RNA Metabolic Process
Regulation Of Gene Expression
Negative Regulation Of Cellular Metabolic Process
Regulation Of Transcription From RNA Polymerase II Promoter
Cellular Macromolecule Biosynthetic Process
Macromolecule Biosynthetic Process
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Nucleobase-containing Compound Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Regulation Of Metabolic Process
Biosynthetic Process
Nitrogen Compound Metabolic Process
Positive Regulation Of Gene Expression
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Cellular Metabolic Process
Transcription From RNA Polymerase II Promoter
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Cellular Biosynthetic Process
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Positive Regulation Of Metabolic Process
Intracellular Receptor Signaling Pathway
Regulation Of Cellular Process
Cellular Metabolic Process
Transcription Initiation From RNA Polymerase II Promoter
Response To Organic Substance
Organ Development
Chromatin Organization
Cellular Response To Organic Substance
Cell Differentiation
Hemopoiesis
DNA-templated Transcription, Initiation
Chromosome Organization
Developmental Process
Immune System Development
Cellular Response To Stimulus
Tagcloud
?
acetylation
acetyltransferases
atf2
chip
d54mg
deacetylase
erythematosus
favoring
gcn5
globally
h4
h4ac
h4k12
h4k16
h4k5
h4k8
hdac11
imbalance
irf1
k12
k16
k8
look
lupus
monocytes
overexpressing
pcaf
seq
sle
Tagcloud (Difference)
?
acetylation
acetyltransferases
atf2
chip
d54mg
deacetylase
erythematosus
favoring
gcn5
globally
h4
h4ac
h4k12
h4k16
h4k5
h4k8
hdac11
imbalance
irf1
k12
k16
k8
look
lupus
monocytes
overexpressing
pcaf
seq
sle
Tagcloud (Intersection)
?