HIST1H4A and ERCC6

Number of citations of the paper that reports this interaction (PMID 11003660)
80

Data Source:
BioGRID (far western blotting)

		HIST1H4A	ERCC6
Gene Name		histone cluster 1, H4a	excision repair cross-complementation group 6
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Chromosome Nucleosome Extracellular Region Nucleus Nucleoplasm Membrane Protein Complex Extracellular Vesicular Exosome	Nucleus Nucleoplasm Nucleolus Transcription Elongation Factor Complex
	Molecular Function	DNA Binding Protein Binding Histone Demethylase Activity (H4-K20 Specific) Poly(A) RNA Binding Protein Heterodimerization Activity	DNA Binding DNA Helicase Activity Chromatin Binding Protein Binding ATP Binding Protein C-terminus Binding DNA-dependent ATPase Activity Protein Tyrosine Kinase Activator Activity Protein Complex Binding Protein N-terminus Binding
	Biological Process	Chromatin Silencing At RDNA Mitotic Cell Cycle Telomere Maintenance Chromatin Organization Nucleosome Assembly DNA Replication-dependent Nucleosome Assembly DNA Replication-independent Nucleosome Assembly Gene Expression DNA Methylation On Cytosine CENP-A Containing Nucleosome Assembly Histone H4-K20 Demethylation Regulation Of Gene Expression, Epigenetic Negative Regulation Of Megakaryocyte Differentiation Negative Regulation Of Gene Expression, Epigenetic	Response To Superoxide DNA Repair Transcription-coupled Nucleotide-excision Repair Base-excision Repair Nucleotide-excision Repair Pyrimidine Dimer Repair Transcription Elongation From RNA Polymerase I Promoter Transcription From RNA Polymerase II Promoter Response To Oxidative Stress Activation Of JNKK Activity Activation Of JUN Kinase Activity Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To UV Response To Toxic Substance Response To X-ray Response To UV-B Response To Gamma Radiation Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of DNA-templated Transcription, Elongation Multicellular Organism Growth Photoreceptor Cell Maintenance Positive Regulation Of Protein Tyrosine Kinase Activity
Pathways		RNA Polymerase I Chain Elongation RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription Mitotic Prophase PKMTs methylate histone lysines Regulatory RNA pathways RNA Polymerase I Promoter Clearance Deposition of new CENPA-containing nucleosomes at the centromere HDMs demethylate histones Cellular Senescence Signaling by Wnt HATs acetylate histones M Phase Amyloids NoRC negatively regulates rRNA expression Packaging Of Telomere Ends Telomere Maintenance Nucleosome assembly RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN DNA methylation Transcriptional regulation by small RNAs Meiotic recombination DNA Damage/Telomere Stress Induced Senescence Chromosome Maintenance HDACs deacetylate histones Chromatin organization misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling RNA Polymerase I Transcription formation of the beta-catenin:TCF transactivating complex Meiotic synapsis Epigenetic regulation of gene expression Senescence-Associated Secretory Phenotype (SASP) Negative epigenetic regulation of rRNA expression PRC2 methylates histones and DNA Cell Cycle, Mitotic RMTs methylate histone arginines Chromatin modifying enzymes Oxidative Stress Induced Senescence TCF dependent signaling in response to WNT RNA Polymerase I Promoter Opening SIRT1 negatively regulates rRNA Expression Signaling by WNT in cancer Condensation of Prophase Chromosomes	Nucleotide Excision Repair RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription Transcription-coupled NER (TC-NER) RNA Polymerase I Transcription RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Clearance Formation of transcription-coupled NER (TC-NER) repair complex Dual incision reaction in TC-NER
Drugs
Diseases
GWAS		HIV-1 viral setpoint ( 22174851)
Protein-Protein Interactions		73 interactors: ANP32A BAZ1B BAZ2A BLOC1S1 BRD2 CALCOCO1 CBX3 CDK1 CDK2 COPS2 CREBBP CTDP1 DYRK1A EID1 ELP3 EP300 ERCC6 GATAD2A GATAD2B HAT1 HDAC1 HDAC2 HDAC3 HDAC8 HIRIP3 HIST1H3A HIST2H2AC HIST2H2BE HJURP KAT2A KAT2B KAT5 KAT6A KAT7 KAT8 KDM4A KMT2A L3MBTL2 MSL2 MSL3 NASP NCOR1 NCOR2 NPM1 NR1H4 PAK1 PARP1 PARP10 PBRM1 PELP1 PHF20 PHF8 PRMT1 PRMT5 PRMT7 PRMT8 PTMA RCC1 SETD7 SIRT7 SSRP1 SUV420H1 SUV420H2 TAF1 TAF1A TAF1B TBL1X THAP7 TP53BP1 UBC UBE2I UCHL5 YY1	15 interactors: BRCA1 CHEK2 ERCC5 ERCC8 GTF2E2 HIST1H2AB HIST1H2BB HIST1H3A HIST1H4A PARP1 POLR2A RNF11 TP53 XAB2 XPA
Entrez ID		8359	2074
HPRD ID		04157	00596
Ensembl ID		ENSG00000196176	ENSG00000225830
Uniprot IDs		B2R4R0 P62805	Q03468 Q59FF6 Q8N328
PDB IDs		2BQZ 2CV5 2KWN 2KWO 2LVM 2QQS 2RNY 2RS9 3A6N 3AFA 3AN2 3AV1 3AV2 3AYW 3AZE 3AZF 3AZG 3AZH 3AZI 3AZJ 3AZK 3AZL 3AZM 3AZN 3CFS 3CFV 3F9W 3F9X 3F9Y 3F9Z 3NQJ 3NQU 3O36 3QZS 3QZT 3QZV 3R45 3UVW 3UVX 3UVY 3UW9 3W96 3W97 3W98 3W99 4GQB 4H9N 4H9O 4H9P 4H9Q 4H9R 4H9S 4HGA
Enriched GO Terms of Interacting Partners?		Chromatin Organization Chromatin Modification Chromosome Organization Histone Modification Transcription, DNA-templated RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Cellular Macromolecule Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Macromolecule Biosynthetic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Organelle Organization RNA Metabolic Process Gene Expression Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Biosynthetic Process Nitrogen Compound Metabolic Process Peptidyl-lysine Modification Regulation Of Metabolic Process Peptidyl-lysine Acetylation Peptidyl-amino Acid Modification Protein Acetylation Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Histone Acetylation Negative Regulation Of RNA Biosynthetic Process Internal Peptidyl-lysine Acetylation Cellular Protein Modification Process Internal Protein Amino Acid Acetylation Negative Regulation Of Gene Expression Cellular Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Gene Expression Histone H4 Acetylation Cellular Protein Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Biosynthetic Process Chromatin Remodeling Chromatin Assembly Or Disassembly Regulation Of Cellular Process Positive Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter	DNA Metabolic Process DNA Repair Nucleotide-excision Repair Cellular Response To DNA Damage Stimulus Transcription-coupled Nucleotide-excision Repair Cellular Response To Stress Response To Radiation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Response To UV Chromatin Assembly Response To Ionizing Radiation Cellular Nitrogen Compound Metabolic Process Double-strand Break Repair Chromatin Assembly Or Disassembly Protein Autoubiquitination DNA Packaging Intrinsic Apoptotic Signaling Pathway Nitrogen Compound Metabolic Process Response To Stress DNA Replication-dependent Nucleosome Assembly DNA Conformation Change Signal Transduction In Response To DNA Damage DNA Methylation On Cytosine DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator Response To Abiotic Stimulus DNA Damage Response, Signal Transduction Resulting In Transcription Chromatin Silencing At RDNA Response To Light Stimulus Replicative Senescence Apoptotic Signaling Pathway Nucleosome Assembly Nucleotide-excision Repair, DNA Damage Removal Nucleosome Organization Negative Regulation Of Biosynthetic Process DNA Damage Checkpoint Response To Oxidative Stress Cellular Macromolecule Catabolic Process Response To X-ray Protein-DNA Complex Assembly Transcription Initiation From RNA Polymerase II Promoter Chromatin Silencing Positive Regulation Of DNA Repair Regulation Of Gene Expression, Epigenetic Chromosome Organization Protein Complex Assembly Negative Regulation Of Reactive Oxygen Species Metabolic Process DNA-templated Transcription, Initiation
Tagcloud ?			abca1 adamtsl3 aiming apc crc elac1 epha3 ephb6 excluding exome fbxw7 germline kbiosciences marginal mll3 obscn pkhd1 recessive rs4987622 rs6464211 rs6947538 silico smad4 snps somatic spite strongest syne1 trpv6
Tagcloud (Difference) ?			abca1 adamtsl3 aiming apc crc elac1 epha3 ephb6 excluding exome fbxw7 germline kbiosciences marginal mll3 obscn pkhd1 recessive rs4987622 rs6464211 rs6947538 silico smad4 snps somatic spite strongest syne1 trpv6
Tagcloud (Intersection) ?