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HIST1H4A and TP53BP1
Number of citations of the paper that reports this interaction (PMID
17190600
)
231
Data Source:
BioGRID
(unspecified method, x-ray crystallography)
HIST1H4A
TP53BP1
Gene Name
histone cluster 1, H4a
tumor protein p53 binding protein 1
Image
Gene Ontology Annotations
Cellular Component
Nuclear Chromosome
Nucleosome
Extracellular Region
Nucleus
Nucleoplasm
Membrane
Protein Complex
Extracellular Vesicular Exosome
Condensed Chromosome Kinetochore
Chromosome, Telomeric Region
Nucleus
Nucleoplasm
Replication Fork
Cytoplasm
Molecular Function
DNA Binding
Protein Binding
Histone Demethylase Activity (H4-K20 Specific)
Poly(A) RNA Binding
Protein Heterodimerization Activity
RNA Polymerase II Activating Transcription Factor Binding
RNA Polymerase II Transcription Cofactor Activity
P53 Binding
Damaged DNA Binding
Protein Binding
Methylated Histone Binding
Telomeric DNA Binding
Biological Process
Chromatin Silencing At RDNA
Mitotic Cell Cycle
Telomere Maintenance
Chromatin Organization
Nucleosome Assembly
DNA Replication-dependent Nucleosome Assembly
DNA Replication-independent Nucleosome Assembly
Gene Expression
DNA Methylation On Cytosine
CENP-A Containing Nucleosome Assembly
Histone H4-K20 Demethylation
Regulation Of Gene Expression, Epigenetic
Negative Regulation Of Megakaryocyte Differentiation
Negative Regulation Of Gene Expression, Epigenetic
Double-strand Break Repair Via Homologous Recombination
DNA Repair
Double-strand Break Repair
Transcription From RNA Polymerase II Promoter
Cellular Response To DNA Damage Stimulus
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Pathways
RNA Polymerase I Chain Elongation
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
Mitotic Prophase
PKMTs methylate histone lysines
Regulatory RNA pathways
RNA Polymerase I Promoter Clearance
Deposition of new CENPA-containing nucleosomes at the centromere
HDMs demethylate histones
Cellular Senescence
Signaling by Wnt
HATs acetylate histones
M Phase
Amyloids
NoRC negatively regulates rRNA expression
Packaging Of Telomere Ends
Telomere Maintenance
Nucleosome assembly
RNF mutants show enhanced WNT signaling and proliferation
XAV939 inhibits tankyrase, stabilizing AXIN
DNA methylation
Transcriptional regulation by small RNAs
Meiotic recombination
DNA Damage/Telomere Stress Induced Senescence
Chromosome Maintenance
HDACs deacetylate histones
Chromatin organization
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
RNA Polymerase I Transcription
formation of the beta-catenin:TCF transactivating complex
Meiotic synapsis
Epigenetic regulation of gene expression
Senescence-Associated Secretory Phenotype (SASP)
Negative epigenetic regulation of rRNA expression
PRC2 methylates histones and DNA
Cell Cycle, Mitotic
RMTs methylate histone arginines
Chromatin modifying enzymes
Oxidative Stress Induced Senescence
TCF dependent signaling in response to WNT
RNA Polymerase I Promoter Opening
SIRT1 negatively regulates rRNA Expression
Signaling by WNT in cancer
Condensation of Prophase Chromosomes
Homologous Recombination Repair
Homologous recombination repair of replication-independent double-strand breaks
Recruitment of repair and signaling proteins to double-strand breaks
Double-Strand Break Repair
Drugs
Diseases
GWAS
HIV-1 viral setpoint (
22174851
)
Protein-Protein Interactions
73 interactors:
ANP32A
BAZ1B
BAZ2A
BLOC1S1
BRD2
CALCOCO1
CBX3
CDK1
CDK2
COPS2
CREBBP
CTDP1
DYRK1A
EID1
ELP3
EP300
ERCC6
GATAD2A
GATAD2B
HAT1
HDAC1
HDAC2
HDAC3
HDAC8
HIRIP3
HIST1H3A
HIST2H2AC
HIST2H2BE
HJURP
KAT2A
KAT2B
KAT5
KAT6A
KAT7
KAT8
KDM4A
KMT2A
L3MBTL2
MSL2
MSL3
NASP
NCOR1
NCOR2
NPM1
NR1H4
PAK1
PARP1
PARP10
PBRM1
PELP1
PHF20
PHF8
PRMT1
PRMT5
PRMT7
PRMT8
PTMA
RCC1
SETD7
SIRT7
SSRP1
SUV420H1
SUV420H2
TAF1
TAF1A
TAF1B
TBL1X
THAP7
TP53BP1
UBC
UBE2I
UCHL5
YY1
34 interactors:
ARAP1
ATM
BLM
BRCA1
CCNB1
CDK1
CRB2
DCLRE1A
DCLRE1C
DYNLL1
E2F1
EP300
GALNTL5
H2AFX
HIST1H4A
HIST2H4A
HIST4H4
IFI16
LIG4
MDC1
MEOX2
NCOA3
NEK1
NFKB1
PAXIP1
PCNT
PLK1
RAD18
RELA
SPAG9
TFDP1
TP53
USP28
VAC14
Entrez ID
8359
7158
HPRD ID
04157
05569
Ensembl ID
ENSG00000196176
ENSG00000067369
Uniprot IDs
B2R4R0
P62805
F8VY86
Q12888
PDB IDs
2BQZ
2CV5
2KWN
2KWO
2LVM
2QQS
2RNY
2RS9
3A6N
3AFA
3AN2
3AV1
3AV2
3AYW
3AZE
3AZF
3AZG
3AZH
3AZI
3AZJ
3AZK
3AZL
3AZM
3AZN
3CFS
3CFV
3F9W
3F9X
3F9Y
3F9Z
3NQJ
3NQU
3O36
3QZS
3QZT
3QZV
3R45
3UVW
3UVX
3UVY
3UW9
3W96
3W97
3W98
3W99
4GQB
4H9N
4H9O
4H9P
4H9Q
4H9R
4H9S
4HGA
1GZH
1KZY
1XNI
2G3R
2IG0
2LVM
3LGF
3LGL
3LH0
Enriched GO Terms of Interacting Partners
?
Chromatin Organization
Chromatin Modification
Chromosome Organization
Histone Modification
Transcription, DNA-templated
RNA Biosynthetic Process
Regulation Of RNA Metabolic Process
Regulation Of RNA Biosynthetic Process
Cellular Macromolecule Biosynthetic Process
Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Macromolecule Biosynthetic Process
Regulation Of Gene Expression
Regulation Of Nitrogen Compound Metabolic Process
Organelle Organization
RNA Metabolic Process
Gene Expression
Nucleobase-containing Compound Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Biosynthetic Process
Nitrogen Compound Metabolic Process
Peptidyl-lysine Modification
Regulation Of Metabolic Process
Peptidyl-lysine Acetylation
Peptidyl-amino Acid Modification
Protein Acetylation
Negative Regulation Of Transcription, DNA-templated
Negative Regulation Of Nucleic Acid-templated Transcription
Histone Acetylation
Negative Regulation Of RNA Biosynthetic Process
Internal Peptidyl-lysine Acetylation
Cellular Protein Modification Process
Internal Protein Amino Acid Acetylation
Negative Regulation Of Gene Expression
Cellular Metabolic Process
Negative Regulation Of Biosynthetic Process
Negative Regulation Of Cellular Metabolic Process
Positive Regulation Of Gene Expression
Histone H4 Acetylation
Cellular Protein Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Regulation Of Transcription From RNA Polymerase II Promoter
Positive Regulation Of Cellular Biosynthetic Process
Chromatin Remodeling
Chromatin Assembly Or Disassembly
Regulation Of Cellular Process
Positive Regulation Of Transcription, DNA-templated
Transcription From RNA Polymerase II Promoter
Cell Cycle
Cellular Response To DNA Damage Stimulus
Cellular Response To Stress
Response To Ionizing Radiation
Mitotic Cell Cycle
Cell Cycle Process
DNA Damage Checkpoint
DNA Metabolic Process
Response To Abiotic Stimulus
Response To Radiation
Mitotic Cell Cycle Process
Cell Cycle Checkpoint
DNA Repair
Nucleobase-containing Compound Metabolic Process
Chromosome Organization
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Signal Transduction By P53 Class Mediator
Intrinsic Apoptotic Signaling Pathway
Cellular Nitrogen Compound Metabolic Process
Double-strand Break Repair
Response To Stress
Organelle Organization
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Nitrogen Compound Metabolic Process
Positive Regulation Of Cellular Metabolic Process
Cellular Response To Stimulus
Negative Regulation Of Cellular Metabolic Process
Cell Death
Telomere Maintenance
Death
Apoptotic Signaling Pathway
DNA Recombination
Intracellular Signal Transduction
Regulation Of Metabolic Process
G2 DNA Damage Checkpoint
Chromatin Organization
Mitotic Cell Cycle Phase Transition
Histone Modification
Cell Cycle Phase Transition
Apoptotic Process
DNA Conformation Change
Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator
Programmed Cell Death
DNA Packaging
Positive Regulation Of Gene Expression
Regulation Of Protein Metabolic Process
Positive Regulation Of Metabolic Process
G2/M Transition Of Mitotic Cell Cycle
Regulation Of Cellular Protein Metabolic Process
Tagcloud
?
abstract
adenocarcinoma
bonferroni
carcinogenesis
cardia
cc
confirm
correction
ga
gc
gca
genotype
genotypes
ldr
ligation
needed
nucleotide
p21
p73
polymorphisms
remained
remaining
replication
rs1059234
rs3176352
rs560191
rs762623
snps
tt
Tagcloud (Difference)
?
abstract
adenocarcinoma
bonferroni
carcinogenesis
cardia
cc
confirm
correction
ga
gc
gca
genotype
genotypes
ldr
ligation
needed
nucleotide
p21
p73
polymorphisms
remained
remaining
replication
rs1059234
rs3176352
rs560191
rs762623
snps
tt
Tagcloud (Intersection)
?