H4C1 and CDK1

Number of citations of the paper that reports this interaction (PubMedID 21840486)
0

Data Source:
BioGRID (enzymatic study)

		H4C1	CDK1
Description		H4 clustered histone 1	cyclin dependent kinase 1
Image
GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleosome Extracellular Region Nucleus Nucleoplasm Chromosome Membrane Protein-containing Complex CENP-A Containing Nucleosome Extracellular Exosome	Cyclin-dependent Protein Kinase Holoenzyme Complex Chromosome, Telomeric Region Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Matrix Endoplasmic Reticulum Membrane Centrosome Spindle Cytosol Cytoskeleton Spindle Microtubule Membrane Midbody Extracellular Exosome Mitotic Spindle Cyclin A1-CDK1 Complex Cyclin A2-CDK1 Complex Cyclin B1-CDK1 Complex
	Molecular Function	DNA Binding RNA Binding Protein Binding Structural Constituent Of Chromatin Protein Heterodimerization Activity	Nucleotide Binding Virus Receptor Activity Chromatin Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding ATP Binding RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity Kinase Activity Transferase Activity Cyclin Binding Hsp70 Protein Binding Histone Kinase Activity Cyclin-dependent Protein Kinase Activity Protein Serine Kinase Activity
	Biological Process	Chromatin Organization Nucleosome Assembly Telomere Organization Negative Regulation Of Megakaryocyte Differentiation Protein Localization To CENP-A Containing Chromatin	G1/S Transition Of Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Microtubule Cytoskeleton Organization DNA Replication DNA Repair Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Apoptotic Process DNA Damage Response Nuclear Envelope Organization Mitotic Nuclear Membrane Disassembly Mitotic G2 DNA Damage Checkpoint Signaling Centrosome Cycle Pronuclear Fusion Response To Toxic Substance Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Schwann Cell Differentiation Response To Amine Response To Activity Cell Migration Protein Deubiquitination Peptidyl-threonine Phosphorylation Chromosome Condensation Epithelial Cell Differentiation Protein Localization To Kinetochore Positive Regulation Of Protein Import Into Nucleus Response To Hydrogen Peroxide Regulation Of Circadian Rhythm Negative Regulation Of Apoptotic Process Mitotic Cell Cycle Phase Transition Response To Ethanol Positive Regulation Of DNA Replication Regulation Of Embryonic Development Thymidine Biosynthetic Process Response To Cadmium Ion Response To Copper Ion Symbiont Entry Into Host Cell Microtubule Polymerization Fibroblast Proliferation Rhythmic Process Response To Axon Injury Cell Division Ventricular Cardiac Muscle Cell Development Positive Regulation Of Cardiac Muscle Cell Proliferation Cilium Disassembly Positive Regulation Of Mitotic Sister Chromatid Segregation Protein-containing Complex Assembly Cellular Response To Hydrogen Peroxide ERK1 And ERK2 Cascade Golgi Disassembly DNA Strand Resection Involved In Replication Fork Processing Positive Regulation Of Protein Localization To Nucleus Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Microtubule Cytoskeleton Organization Involved In Mitosis DNA Synthesis Involved In Mitotic DNA Replication Positive Regulation Of Mitochondrial ATP Synthesis Coupled Electron Transport Protein Localization To Site Of Double-strand Break Mitotic DNA-templated DNA Replication
Pathways		Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Pre-NOTCH Transcription and Translation Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex PRC2 methylates histones and DNA Condensation of Prophase Chromosomes Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) DNA Damage/Telomere Stress Induced Senescence HDACs deacetylate histones PKMTs methylate histone lysines HDMs demethylate histones HATs acetylate histones HATs acetylate histones RMTs methylate histone arginines SIRT1 negatively regulates rRNA expression ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression NoRC negatively regulates rRNA expression NoRC negatively regulates rRNA expression SUMOylation of chromatin organization proteins B-WICH complex positively regulates rRNA expression DNA methylation Transcriptional regulation by small RNAs Activation of anterior HOX genes in hindbrain development during early embryogenesis Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends Deposition of new CENPA-containing nucleosomes at the centromere Assembly of the ORC complex at the origin of replication G2/M DNA damage checkpoint RNA Polymerase I Promoter Opening RNA Polymerase I Promoter Escape RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs Estrogen-dependent gene expression Meiotic recombination HCMV Early Events HCMV Late Events Transcriptional regulation of granulopoiesis Inhibition of DNA recombination at telomere Defective pyroptosis Negative Regulation of CDH1 Gene Transcription Amyloid fiber formation Chromatin modifications during the maternal to zygotic transition (MZT) Replacement of protamines by nucleosomes in the male pronucleus MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis Regulation of endogenous retroelements by KRAB-ZFP proteins Regulation of endogenous retroelements by KRAB-ZFP proteins Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) Regulation of PD-L1(CD274) transcription	MAPK3 (ERK1) activation E2F-enabled inhibition of pre-replication complex formation Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 Golgi Cisternae Pericentriolar Stack Reorganization APC/C:Cdc20 mediated degradation of Cyclin B Cdc20:Phospho-APC/C mediated degradation of Cyclin A Regulation of APC/C activators between G1/S and early anaphase Phosphorylation of the APC/C Phosphorylation of Emi1 Condensation of Prophase Chromosomes MASTL Facilitates Mitotic Progression Resolution of Sister Chromatid Cohesion Condensation of Prometaphase Chromosomes Regulation of PLK1 Activity at G2/M Transition Activation of NIMA Kinases NEK9, NEK6, NEK7 Initiation of Nuclear Envelope (NE) Reformation Nuclear Pore Complex (NPC) Disassembly Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Depolymerization of the Nuclear Lamina Anchoring of the basal body to the plasma membrane MAPK6/MAPK4 signaling Ovarian tumor domain proteases TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest Regulation of TP53 Degradation Mitotic Prophase G1/S-Specific Transcription Cyclin A/B1/B2 associated events during G2/M transition G2/M DNA replication checkpoint Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex The role of GTSE1 in G2/M progression after G2 checkpoint AURKA Activation by TPX2 Transcriptional regulation by RUNX2 PKR-mediated signaling
Drugs			Indirubin-3'-monoxime Olomoucine Hymenialdisine SU9516 Alvocidib Alsterpaullone Seliciclib AT-7519 Fostamatinib Avotaciclib
Diseases
GWAS			Cocaine dependence ( 23958962) Voxel-wise structural brain imaging measurements in Alzheimer’s disease ( 31095298)
Interacting Genes		85 interacting genes: ANP32A ANP32B ASF1A BAZ2A CBX3 CDK1 CDK2 CEBPA CHD4 COPS2 DPF2 DYRK1A EID1 ELP3 EP300 ERCC6 EXO1 FANCD2 GATAD2A GATAD2B HDAC3 HDAC8 HIRIP3 HJURP JADE1 JMJD6 KAT14 KAT2B KAT5 KAT6A KAT7 KAT8 KDM4A KMT2C KMT2D KMT5A KMT5B KMT5C L3MBTL2 MBTD1 MRE11 MSL2 MSL3 MYB NAA10 NAP1L1 NCOR1 NCOR2 NSD1 NSD3 ORC1 PAK1 PALB2 PARP10 PBRM1 PELP1 PHF1 PHF20 PHF8 PRMT1 PRMT5 PRMT7 PRMT8 PSME4 PTMA RAD23A RBBP7 SETD7 SHPRH SIRT7 SMYD5 SUPT16H TAF1A TAF1B TBL1X THAP7 TLE3 TP53BP1 TRIM24 TRIM28 TRIM29 TSPYL5 UCHL5 WBP2 ZMYND11	241 interacting genes: ABL1 ACSL4 ADD1 AKAP12 AKT1 AMPH APLP2 AR ARID4A BARD1 BCL2 BCL2L11 BIRC5 BIRC6 BRCA1 BRCA2 BTG2 BTRC BUB1 CALD1 CCNA1 CCNA2 CCNB1 CCNB1IP1 CCNB2 CCNE1 CCP110 CD8A CDC20 CDC25A CDC25B CDC25C CDCA2 CDCA5 CDK7 CDKN1A CDKN3 CDT1 CEBPA CENPF CEP55 CEP63 CHAF1B CIITA CIP2A CKS2 CNOT7 CREB1 CREM CSN2 CSNK2A1 CSNK2B CTNNB1 CUL4B CUX1 CXCR1 DAB2 DCTN6 DNM2 DTL DUT E2F1 ECT2 EEF1D EEF2K EML3 EPN1 ERCC2 ERCC6L FANCA FANCC FANCG FBXO5 FEN1 FLNA FOXM1 FOXO1 FYN GADD45A GADD45B GADD45G GAS2L3 GATA2 GBF1 GFAP GOLGA2 GORASP1 H1-0 H1-1 H1-3 H1-5 H2AC4 H2BC3 H4C1 HASPIN HJURP HMGA1 HMGA2 HMGB1 HSPA2 HTRA2 ID2 IDH1 IDH2 IL16 IL3RA IQGAP1 ITGB3 ITPR1 JAK3 KAT5 KHDRBS1 KIF11 KIF20B KIF26B KMT2E KRT18 LATS1 LMNA LMNB1 LRRK1 LYN LZTS1 MAP4 MAPK12 MAPT MBP MCM2 MCM4 MDM4 MEF2C MIS18BP1 MISP MKI67 MLKL MLST8 MNDA MYC MYT1 NCAPD2 NCAPD3 NCAPG NCAPH NCL NDE1 NEDD1 NES NHERF1 NONO NPM1 NSFL1C NUP210 PAK6 PBK PCM1 PCNA PIN1 PIP5K1C PITPNM1 PKMYT1 PLEC PML POLA1 POLL PON1 PPP1R12A PPP2R1A PPP2R1B PPP2R2B PPP4R2 PPP4R3A PRC1 PRDX1 PRDX2 PRKAR2A PSRC1 PTCH1 PTMA PTPN1 PTPN2 PTPN6 PTTG1 RAB4A RAB5B RACGAP1 RAD9A RANGAP1 RAP1GAP RB1 RCC1 RELB REPS2 RGCC RPA2 RPS3 RPS6KB1 RRM2 RSF1 RUNX1 RUNX2 SAMHD1 SFN SLBP SOX2 SP1 SPAG5 SQSTM1 SRC SSBP1 STK3 STMN1 STMN2 TERF1 TFDP1 TGFBR2 TK1 TLE1 TMPO TNNC1 TOP2A TP53 TP53BP1 TP73 TPR TSC1 TSPYL2 TUBB UBA1 UBE2A UBE3A UHRF2 USP14 USP16 VHL VIM WAC WEE1 XIAP XPO1 XRCC6 ZBTB16
Entrez ID		8359	983
HPRD ID		04157	00302
Ensembl ID		ENSG00000278637	ENSG00000170312
Uniprot IDs		P62805	B7Z3D6 I6L9I5 P06493
PDB IDs		1ZKK 2BQZ 2CV5 2IG0 2KWN 2KWO 2LVM 2QQS 2RJE 2RNY 2RS9 3A6N 3AFA 3AN2 3AV1 3AV2 3AYW 3AZE 3AZF 3AZG 3AZH 3AZI 3AZJ 3AZK 3AZL 3AZM 3AZN 3CFS 3CFV 3F9W 3F9X 3F9Y 3F9Z 3IJ1 3JPX 3NQJ 3NQU 3O36 3QBY 3QZS 3QZT 3QZV 3R45 3UVW 3UVX 3UVY 3UW9 3W96 3W97 3W98 3W99 3WA9 3WAA 3WKJ 3WTP 3X1S 3X1T 3X1U 3X1V 4GQB 4H9N 4H9O 4H9P 4H9Q 4H9R 4H9S 4HGA 4M38 4N3W 4N4F 4QUT 4QUU 4QYD 4U9W 4YM5 4YM6 4YY6 4YYD 4YYG 4YYH 4YYI 4YYJ 4YYK 4YYM 4YYN 4Z2M 4Z5T 5AV5 5AV6 5AV8 5AV9 5AVB 5AVC 5AY8 5B0Y 5B0Z 5B24 5B2I 5B2J 5B31 5B32 5B33 5B40 5BNV 5BNX 5BO0 5C3I 5CPI 5CPJ 5CPK 5FA5 5FFW 5FWE 5GSE 5GSU 5GT0 5GT3 5GTC 5GXQ 5JA4 5JRG 5KDM 5TEG 5X7X 5XF3 5XF4 5XF5 5Y0C 5Y0D 5YE3 5YE4 5Z23 5Z30 5ZBX 5ZGC 6A5L 6A5O 6A5P 6A5R 6A5T 6A5U 6ACP 6BUZ 6C0W 6E0C 6E0P 6FML 6HKT 6HTS 6INQ 6IR9 6J4W 6J4X 6J4Y 6J4Z 6J50 6J51 6JOU 6JR0 6JR1 6K1I 6K1J 6K1K 6KE9 6KVD 6KXV 6L49 6L4A 6L9H 6L9Z 6LA2 6LA8 6LA9 6LAB 6LE9 6LER 6M3V 6M44 6M4D 6M4G 6M4H 6MLC 6MUO 6MUP 6O1D 6R0C 6R8Y 6R8Z 6R90 6R91 6R92 6R93 6R94 6RNY 6RXS 6SE0 6SE6 6SEE 6SEF 6SEG 6T79 6T7A 6T7B 6T7C 6T7D 6T90 6T93 6UPK 6UPL 6USJ 6V2K 6V92 6VO5 6X59 6X5A 6XJD 6Y5D 6YOV 7A08 7BWD 7BXT 7BY0 7C0M 7CCQ 7CCR 7CIZ 7CJ0 7COW 7D1Z 7D20 7DBP 7E8D 7EIC 7EID 7JO9 7JOA 7JZV 7K5X 7K5Y 7K60 7K61 7K63 7LMK 7LMM 7LYA 7LYB 7LYC 7M98 7NL0 7PET 7PEU 7PEV 7PEW 7PEX 7PEY 7PEZ 7PF0 7PF2 7PF3 7PF4 7PF5 7PF6 7PFA 7PFC 7PFD 7PFE 7PFF 7PFT 7PFU 7PFV 7PFW 7PFX 7PII 7R5R 7SCY 7SCZ 7TAN 7U0G 7U0I 7U0J 7U46 7U47 7U4D 7U50 7U51 7U52 7U53 7UV9 7V1M 7V6Q 7V90 7V96 7V9C 7V9J 7V9K 7V9S 7VA4 7VCQ 7VZ4 7W9V 7WBV 7WBW 7WBX 7X57 7X58 7XCR 7XCT 7XD0 7XD1 7XSE 7XSX 7XSZ 7XT7 7XTD 7XTI 7XVL 7XVM 7XX5 7XX6 7XZX 7XZY 7XZZ 7Y00 7Y5U 7Y5V 7Y5W 7Y60 7Y61 7Y7I 7Y8R 7YOZ 7YQK 7YRD 7YWX 7YYH 7ZI4 8AAG 8ATF 8AV6 8B5A 8B5B 8B5C 8DK5 8EVG 8EVH 8EVI 8EVJ 8GRM 8GRQ 8GUI 8GUJ 8GUK 8H0V 8H0W 8H1T 8HAG 8HAH 8HAI 8HAJ 8HAK 8HAL 8HAM 8HAN 8HE5 8HLW 8HR1 8IEG 8IEJ 8IHL 8IQF 8IQG 8J6S 8J6T 8JBX 8JCC 8JCD 8JH2 8JH3 8JH4 8JHF 8JHG 8JL9 8JLA 8JLB 8JLD 8JND 8JNE 8JNF 8KB5 8KCY 8KD1 8KE0 8OFF 8OL1 8OO7 8OOA 8OOP 8OOS 8OSJ 8OSK 8OSL 8OTS 8OTT 8OX0 8OX1 8PEF 8Q36 8Q3E 8Q3M 8Q3X 8QZM 8RBX 8RGM 8SB6 8SDO 8SDQ 8SDX 8SMW 8SMX 8SMY 8SMZ 8SN0 8SN1 8SN2 8SN3 8SN4 8SN5 8SN6 8SN7 8SN8 8SN9 8SNA 8SPS 8SPU 8SYP 8TGP 8TXV 8TXW 8TXX 8U13 8U14 8UHL 8UK5 8UPF 8VFX 8VFY 8VFZ 8VG0 8VG1 8VG2 8VLR 8VMJ 8VMN 8VOB 8VWS 8VWT 8VWU 8VWV 8W9D 8W9E 8W9F 8WG5 8X15 8X19 8X1C 8X7I 8X7J 8X7K 8XBT 8XBU 8XBW 8Y3C 8Y3D 8Y3E 8Y3F 8YBJ 8YBK 8YJF 8YJM 8YNY 8YTI 8YV8 8Z50 9DWF 9DWG 9DWH 9DWI 9DWJ 9DWK 9DWL 9DWM 9EOZ 9FGQ 9FH9 9GMK 9GMR 9GXA 9IPU 9J0N 9J0O 9J0P 9J8M 9J8N 9J8O	4Y72 4YC3 4YC6 5HQ0 5LQF 6GU2 6GU3 6GU4 6GU6 6GU7 6TWN 7NJ0
Enriched GO Terms of Interacting Partners?		Chromatin Organization Chromatin Remodeling Nucleoplasm Nucleus Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Chromatin Binding Regulation Of Primary Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Positive Regulation Of Nucleobase-containing Compound Metabolic Process DNA Damage Response Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of DNA-templated Transcription Chromosome Negative Regulation Of RNA Biosynthetic Process DNA Repair Negative Regulation Of RNA Metabolic Process DNA Metabolic Process Nucleic Acid Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Cellular Response To Stress Positive Regulation Of RNA Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Histone Methyltransferase Activity Regulation Of DNA Repair Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Histone Binding Positive Regulation Of Biosynthetic Process Nucleobase-containing Compound Metabolic Process Chromatin Regulation Of DNA Metabolic Process Epigenetic Regulation Of Gene Expression Positive Regulation Of Metabolic Process Histone H4 Methyltransferase Activity Transcription Corepressor Activity Methyltransferase Activity Acetyltransferase Activity Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA Metabolic Process	Regulation Of Cell Cycle Regulation Of Cell Cycle Process Cell Division Nucleus Cellular Response To Stress Nucleoplasm DNA Damage Response Regulation Of Mitotic Cell Cycle Organelle Organization Cytosol Cytoplasm Regulation Of Cell Cycle Phase Transition Chromosome Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Negative Regulation Of Cell Cycle Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Cell Cycle Phase Transition Intracellular Signal Transduction Positive Regulation Of Cell Cycle Process Negative Regulation Of Metabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Chromosome Organization DNA Metabolic Process Response To Stress Negative Regulation Of Macromolecule Metabolic Process DNA Repair Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Population Proliferation Cytoskeleton Regulation Of DNA Metabolic Process Positive Regulation Of Programmed Cell Death Negative Regulation Of Cell Cycle Phase Transition Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of Cell Cycle Process Positive Regulation Of Apoptotic Process Protein Kinase Binding Regulation Of Protein Metabolic Process Regulation Of Cellular Component Organization Cell Cycle G2/M Phase Transition Regulation Of Macromolecule Metabolic Process DNA-binding Transcription Factor Binding Positive Regulation Of Mitotic Cell Cycle Regulation Of Intracellular Signal Transduction G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Mitotic Cell Cycle Phase Transition Cellular Component Assembly Negative Regulation Of Mitotic Cell Cycle
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