SDC3 and CTTN

Number of citations: 0 (PubMedID 9553134)
Data Source: HPRD (in vitro)

		SDC3	CTTN
Name		syndecan 3	cortactin
Structure		No pdb structure
GO Annotations	Cellular Component	Golgi Lumen Plasma Membrane Cell Surface Membrane Extracellular Matrix Lysosomal Lumen Microspike	Ruffle Podosome Cytoplasm Endoplasmic Reticulum Golgi Apparatus Cytosol Cytoskeleton Actin Filament Plasma Membrane Clathrin-coated Pit Focal Adhesion Cell Cortex Voltage-gated Potassium Channel Complex Membrane Lamellipodium Cell Junction Endocytic Vesicle Dendrite Growth Cone Cortical Cytoskeleton Cell Projection Dendritic Spine Synapse Anchoring Junction Postsynapse Postsynaptic Actin Cytoskeleton Glutamatergic Synapse Mitotic Spindle Midzone
	Molecular Function	Protein Binding Identical Protein Binding	Protein Binding Profilin Binding Cadherin Binding Proline-rich Region Binding Arp2/3 Complex Binding
	Biological Process	Cell Migration	Intracellular Protein Transport Endocytosis Receptor-mediated Endocytosis Substrate-dependent Cell Migration, Cell Extension Signal Transduction Actin Cytoskeleton Organization Regulation Of Axon Extension Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Smooth Muscle Contraction Focal Adhesion Assembly Neuron Projection Morphogenesis Cell Motility Positive Regulation Of Chemotaxis Regulation Of Cell Projection Assembly Dendritic Spine Maintenance Extrinsic Apoptotic Signaling Pathway Lamellipodium Organization Modification Of Postsynaptic Actin Cytoskeleton Modification Of Postsynaptic Structure Regulation Of Mitophagy Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Glycosaminoglycan-protein linkage region biosynthesis HS-GAG biosynthesis HS-GAG biosynthesis HS-GAG degradation Cell surface interactions at the vascular wall Syndecan interactions Syndecan interactions Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective EXT2 causes exostoses 2 Defective EXT1 causes exostoses 1, TRPS2 and CHDS Defective B3GALT6 causes EDSP2 and SEMDJL1 Attachment and Entry Attachment and Entry Retinoid metabolism and transport Respiratory syncytial virus (RSV) attachment and entry RSV-host interactions	RHO GTPases activate PAKs Clathrin-mediated endocytosis
GWAS		Loneliness ( 27629369 ) Systolic blood pressure ( 34074324 )	No GWAS studies recorded
Interacting Genes		32 interacting genes: AGR2 CASK CMTM7 COL5A1 CSK CTTN CUX1 EPHB4 FGF2 FYN ITGB4 KCNJ2 KRTAP1-1 KRTAP1-3 KRTAP10-3 KRTAP2-3 KRTAP2-4 KRTAP4-2 KRTAP5-7 KRTAP5-9 KRTAP9-2 LCE3D MDK PLN PTN SLC35A1 SMIM1 TMEM14C TMEM218 TUBA1A TUBB TUBB2A	58 interacting genes: ACD ACTA1 ACTG1 ACTR3 ANKZF1 ARHGAP17 ARHGAP8 ATM CASP3 CD2AP CHD3 CPSF7 CTNND1 CTNND2 CTTNBP2 DNM1 DNM2 EGFR FER FGD1 GRB2 GRIA2 GTSE1 HAX1 HIP1R KCNA2 KEAP1 MET MYLK NHSL2 NXF1 PRPF6 RBM15 RPL23A RPL37 RPL9 RSPH1 SDC3 SF1 SF3B4 SFPQ SH3BP2 SHANK2 SHANK3 SIRT1 SMURF1 SPRR2A SRC SYK TINF2 TJP1 TNK2 TRIM15 USP7 WASL WIPF1 YTHDF1 YTHDF3
Entrez ID		9672	2017
HPRD ID		01719	01268
Ensembl ID		ENSG00000162512	ENSG00000085733
Uniprot IDs		O75056	Q14247 Q53HG7
PDB IDs		Not available	1X69 2D1X
GO Terms Enriched among Interactors		Intermediate Filament Keratin Filament Response To Mechanical Stimulus Cell Motility Cell Migration Positive Regulation Of Blood Vessel Branching Regulation Of Blood Vessel Branching Regulation Of Calcium Ion Import Leukocyte Chemotaxis Involved In Inflammatory Response Integrin Binding Cell Projection Morphogenesis Positive Regulation Of Chemotaxis Learning Or Memory Chondroitin Sulfate Binding Positive Regulation Of Hepatocyte Proliferation Dendritic Spine Maintenance Estrous Cycle Heparin Binding Anatomical Structure Morphogenesis Learning Relaxation Of Cardiac Muscle Cognition Regulation Of Response To Wounding Regulation Of Hepatocyte Proliferation Basement Membrane Proline-rich Region Binding Regulation Of Chemotaxis Positive Regulation Of Cell Division Regulation Of Neural Precursor Cell Proliferation Positive Regulation Of Vascular Endothelial Cell Proliferation Response To L-glutamate Relaxation Of Muscle Positive Regulation Of Oligodendrocyte Differentiation Cerebral Cortex Development Response To Auditory Stimulus Ovulation Cycle Leukocyte Migration Involved In Inflammatory Response Neuron Projection Arborization Positive Regulation Of Neurogenesis Positive Regulation Of Stem Cell Differentiation Schaffer Collateral - CA1 Synapse Structural Constituent Of Cytoskeleton Identical Protein Binding Cell Migration Involved In Sprouting Angiogenesis Glial Cell Differentiation Calcium Ion Transport Dentate Gyrus Development Integrin Biosynthetic Process Developmental Process Protein Tyrosine Kinase Activity	SH3 Domain Binding Cellular Component Assembly Cytoplasm Regulation Of Cellular Component Organization Anchoring Junction Lamellipodium Regulation Of Actin Cytoskeleton Organization Regulation Of Organelle Organization Actin Cytoskeleton Actin Filament Regulation Of Actin Filament-based Process Cytosol Organelle Organization Actin Filament Organization Regulation Of Actin Filament Organization Cellular Response To Chemical Stress Protein Tyrosine Kinase Activity Positive Regulation Of Protein-containing Complex Assembly Positive Regulation Of Metabolic Process Negative Regulation Of Telomere Maintenance Actin Filament-based Process Regulation Of Cytoskeleton Organization Vesicle Scission Negative Regulation Of Membrane Tubulation Podosome Grb2-EGFR Complex Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of TOR Signaling Cell Projection Non-membrane Spanning Protein Tyrosine Kinase Activity Regulation Of Vesicle-mediated Transport Postsynapse Organization Response To Reactive Oxygen Species Regulation Of Chromosome Organization Positive Regulation Of Cellular Component Organization Cytoskeleton Regulation Of Intracellular Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Postsynaptic Density Regulation Of Signal Transduction Actin Cytoskeleton Organization Dendritic Spine Morphogenesis Regulation Of Clathrin-dependent Endocytosis Response To Oxidative Stress Positive Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Regulation Of Telomere Maintenance Cellular Response To Reactive Oxygen Species Regulation Of Autophagy Regulation Of Supramolecular Fiber Organization