GCC2 and ICAM3

Data Source: HiPPIP (Novel)

		GCC2	ICAM3
Name		GRIP and coiled-coil domain containing 2	intercellular adhesion molecule 3
Structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Golgi Apparatus Trans-Golgi Network Cytosol Membrane	Plasma Membrane Membrane Extracellular Exosome
	Molecular Function	Protein Binding Small GTPase Binding Identical Protein Binding	Signaling Receptor Binding Integrin Binding Protein Binding
	Biological Process	Protein Targeting To Lysosome Protein Transport Microtubule Organizing Center Organization Protein Localization To Golgi Apparatus Microtubule Anchoring Late Endosome To Golgi Transport Retrograde Transport, Endosome To Golgi Golgi To Plasma Membrane Protein Transport Regulation Of Protein Exit From Endoplasmic Reticulum Recycling Endosome To Golgi Transport Golgi Ribbon Formation	Phagocytosis Cell Adhesion Cell-cell Adhesion
Pathways		Retrograde transport at the Trans-Golgi-Network Signaling by ALK fusions and activated point mutants	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Integrin cell surface interactions CD209 (DC-SIGN) signaling
GWAS		Excessive hairiness ( 29895819 ) Eyebrow thickness ( 26926045 ) Liver enzyme levels (alkaline phosphatase) ( 33972514 ) Low density lipoprotein cholesterol levels ( 32154731 ) Mean platelet volume ( 27863252 ) Platelet distribution width ( 32888494 )	Crohn's disease ( 21102463 28067908 ) Inflammatory bowel disease ( 28067908 ) Rheumatoid arthritis ( 23143596 ) Rheumatoid arthritis (ACPA-positive) ( 23143596 ) Systemic lupus erythematosus or rheumatoid arthritis ( 27193031 )
Novel Interactors		4 novel interactors: ICAM3 POU2AF1 RANBP2 SULT1C3	9 novel interactors: C3 CALR EPOR GCC2 PRLR RFX2 RPL18 TNFRSF1B USF2
Interacting Genes		3 interacting genes: ARL1 SPOP SRPK2	20 interacting genes: APP BRICD5 CD209 CLDN19 CLDN4 CLEC4M EDDM3B EZR ITGAD ITGAL ITGB2 MSN NINJ2 PRKCQ SEC22A SFTPC SMCO4 SMIM1 TSPO ZBTB16
Entrez ID		9648	3385
HPRD ID		11001	00889
Ensembl ID		ENSG00000135968	ENSG00000076662
Uniprot IDs		A0A8I5QJB7 B3KR21 Q8IWJ2	A0A9L9PXS1 P32942
PDB IDs		3BBP	1T0P
GO Terms Enriched among Interactors		None	Leukocyte Cell-cell Adhesion Cell-cell Adhesion ICAM-3 Receptor Activity Cell Surface Cell Adhesion External Side Of Plasma Membrane Integrin AlphaL-beta2 Complex Peptide Antigen Transport Integrin Complex Membrane Cell Adhesion Molecule Binding Regulation Of Immune System Process Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Membrane To Membrane Docking Cell Recognition Paracellular Transport Intracellular Transport Of Virus Endocytosis Positive Regulation Of Early Endosome To Late Endosome Transport Host Cell Positive Regulation Of Protein Localization To Early Endosome Cell-cell Recognition Virion Binding Regulation Of Nitric Oxide Biosynthetic Process Virion Attachment To Host Cell Regulation Of Transport Regulation Of Nitric Oxide Metabolic Process Positive Regulation Of Protein Localization To Endosome Adhesion Of Symbiont To Host Cell Positive Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Immune System Process Uropod Plasma Membrane Regulation Of Cell Population Proliferation Response To Manganese Ion Neuron Remodeling Adhesion Of Symbiont To Host Positive Regulation Of Multicellular Organismal Process Regulation Of Vesicle-mediated Transport Leukocyte Activation Positive Regulation Of Membrane Protein Ectodomain Proteolysis Positive Regulation Of Transport Specific Granule Membrane Establishment Of Epithelial Cell Apical/basal Polarity Positive Regulation Of Protein Catabolic Process Cellular Extravasation Regulation Of Early Endosome To Late Endosome Transport Positive Regulation Of Cell Activation Import Into Cell Vesicle-mediated Transport