FNIP1 and PRKAA1

Number of citations of the paper that reports this interaction (PMID 17028174)
73

Data Source:
BioGRID (affinity chromatography technology, enzymatic study)

		FNIP1	PRKAA1
Gene Name		folliculin interacting protein 1	protein kinase, AMP-activated, alpha 1 catalytic subunit
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm	Intracellular Nucleus Nucleoplasm Cytoplasm Cytosol Apical Plasma Membrane AMP-activated Protein Kinase Complex
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding	Chromatin Binding Protein Kinase Activity AMP-activated Protein Kinase Activity CAMP-dependent Protein Kinase Activity Protein Binding ATP Binding Protein C-terminus Binding Kinase Binding Histone Serine Kinase Activity Metal Ion Binding [hydroxymethylglutaryl-CoA Reductase (NADPH)] Kinase Activity Tau-protein Kinase Activity [acetyl-CoA Carboxylase] Kinase Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Protein Phosphorylation Positive Regulation Of Protein Phosphorylation Immature B Cell Differentiation Positive Regulation Of B Cell Apoptotic Process Cellular Response To Starvation TOR Signaling Negative Regulation Of TOR Signaling Positive Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of GTPase Activity Regulation Of Pro-B Cell Differentiation	Activation Of MAPK Activity Response To Hypoxia Glucose Metabolic Process Transcription, DNA-templated Regulation Of Transcription, DNA-templated Protein Phosphorylation Fatty Acid Biosynthetic Process Cholesterol Biosynthetic Process Autophagy Cell Cycle Arrest Signal Transduction Positive Regulation Of Cell Proliferation Insulin Receptor Signaling Pathway Lipid Biosynthetic Process Response To UV Cold Acclimation Response To Gamma Radiation Positive Regulation Of Autophagy Positive Regulation Of Gene Expression Response To Activity Wnt Signaling Pathway Fatty Acid Oxidation Response To Caffeine Cellular Response To Nutrient Levels Negative Regulation Of TOR Signaling Histone-serine Phosphorylation Cellular Response To Glucose Starvation Glucose Homeostasis Regulation Of Circadian Rhythm Negative Regulation Of Apoptotic Process Positive Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Glycolytic Process Negative Regulation Of Glucosylceramide Biosynthetic Process Rhythmic Process Negative Regulation Of Lipid Catabolic Process Protein Heterooligomerization Fatty Acid Homeostasis Regulation Of Vesicle-mediated Transport Cellular Response To Hydrogen Peroxide Cellular Response To Ethanol Cellular Response To Hypoxia Response To Camptothecin Regulation Of Energy Homeostasis Negative Regulation Of Glucose Import In Response To Insulin Stimulus
Pathways			Insulin receptor signalling cascade Regulation of AMPK activity via LKB1 IRS-mediated signalling Regulation of Rheb GTPase activity by AMPK mTOR signalling IRS-related events mTOR signalling IGF1R signaling cascade IRS-related events triggered by IGF1R IRS-mediated signalling Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) Energy dependent regulation of mTOR by LKB1-AMPK PKB-mediated events PI3K Cascade PKB-mediated events PI3K Cascade Signaling by Insulin receptor
Drugs			Adenosine monophosphate Adenosine triphosphate Phenformin
Diseases
GWAS			Gastric cancer ( 22037551)
Protein-Protein Interactions		2 interactors: FLCN PRKAA1	58 interactors: ABI2 ACACA AES BHLHE40 CAB39 CDX4 CFTR CRTC2 CTBP1 EEF2K EPM2A FNIP1 GATA1 GOLGA2 GRIK2 HDAC5 HMBOX1 HOMEZ IKZF3 INO80E KRT40 L3MBTL3 MAP3K7 MDM4 MORC4 MTOR MTUS2 PFKFB2 PHC2 PLEKHA4 PNMA5 PPP2CA PRKAB1 PRKAB2 PRKAG1 PRKAG3 PSMD11 RAD54B RAF1 RBPMS RFX6 RIMBP3 ROPN1 RPTOR SRPK2 SSX2IP STK11 THAP1 TOMM34 TRIM27 TRIP6 TSC2 TSC22D4 TXNIP UBXN11 VPS37B VPS52 ZBED1
Entrez ID		96459	5562
HPRD ID		17233	04115
Ensembl ID		ENSG00000217128	ENSG00000132356
Uniprot IDs		J3KNG8 Q8TF40	Q13131
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Energy Homeostasis Negative Regulation Of TOR Signaling Regulation Of TOR Signaling Negative Regulation Of Glucosylceramide Biosynthetic Process Negative Regulation Of Energy Homeostasis Cold Acclimation Negative Regulation Of ATP Biosynthetic Process Negative Regulation Of Glucose Import In Response To Insulin Stimulus Response To Camptothecin Negative Regulation Of Intracellular Signal Transduction Regulation Of Pro-B Cell Differentiation Negative Regulation Of Cell Proliferation Involved In Kidney Development Negative Regulation Of Sphingolipid Biosynthetic Process Regulation Of Ceramide Biosynthetic Process Positive Regulation Of Cholesterol Biosynthetic Process Regulation Of MAPK Cascade Positive Regulation Of Cholesterol Metabolic Process Cellular Response To Ethanol Negative Regulation Of Glucose Import Positive Regulation Of Protein Phosphorylation Positive Regulation Of Glycolytic Process Fatty Acid Homeostasis Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Phosphorylation Negative Regulation Of Glucose Transport Positive Regulation Of Protein Modification Process Regulation Of Cell Cycle Regulation Of Glucose Import In Response To Insulin Stimulus Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of TOR Signaling TOR Signaling Histone-serine Phosphorylation Negative Regulation Of Rho Protein Signal Transduction Negative Regulation Of Lipid Catabolic Process Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Glucose Starvation Regulation Of Protein Phosphorylation Negative Regulation Of Signal Transduction Response To Caffeine Regulation Of Glycolytic Process Positive Regulation Of Steroid Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Signaling Regulation Of Cholesterol Metabolic Process Regulation Of Hematopoietic Progenitor Cell Differentiation Negative Regulation Of Mitochondrion Organization Positive Regulation Of Protein Metabolic Process Cholesterol Biosynthetic Process Positive Regulation Of Signal Transduction Positive Regulation Of Autophagy	Insulin Receptor Signaling Pathway Cellular Response To Insulin Stimulus Response To Insulin Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Response To Peptide Hormone Cellular Response To Hormone Stimulus Cellular Response To Organonitrogen Compound Response To Peptide Regulation Of Phosphorylation Regulation Of Protein Phosphorylation Regulation Of Phosphorus Metabolic Process Response To Hormone Cell Cycle Arrest Regulation Of Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Nitrogen Compound Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Kinase Activity Gene Expression Response To Organonitrogen Compound Transcription, DNA-templated Regulation Of Gene Expression Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Cell Cycle Regulation Of Protein Kinase Activity Positive Regulation Of Protein Modification Process RNA Biosynthetic Process Regulation Of Cell Cycle Regulation Of Protein Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Cellular Ketone Metabolic Process Biosynthetic Process Cell Cycle Response To Organic Substance Regulation Of Cellular Amino Acid Metabolic Process Regulation Of Transcription, DNA-templated Positive Regulation Of Metabolic Process Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Cellular Metabolic Process Regulation Of RNA Biosynthetic Process Positive Regulation Of Phosphorylation Cellular Response To Organic Substance Protein Oligomerization RNA Metabolic Process Positive Regulation Of Protein Phosphorylation Protein Heterooligomerization Negative Regulation Of Transcription, DNA-templated Protein Phosphorylation
Tagcloud ?		bhlh circuitry commitment congruently destabilizing drives enforced epiblast esc escs esrrb exit flcn fnip2 folliculin ground integrates lies pluripotency pluripotent relocalization renewal restricting rheostat suppressors sustain tfe3 tsc2 withstand	abeta anticipate atg7 autophagic autophagy catabolic clearance cultures degraded degrades enhancing extracellular fibrils inflammasome ingests interacts knockout lysosomal map1lc3b microglia microglial native nlr nlrp3 optineurin optn promising pyrin resultant
Tagcloud (Difference) ?		bhlh circuitry commitment congruently destabilizing drives enforced epiblast esc escs esrrb exit flcn fnip2 folliculin ground integrates lies pluripotency pluripotent relocalization renewal restricting rheostat suppressors sustain tfe3 tsc2 withstand	abeta anticipate atg7 autophagic autophagy catabolic clearance cultures degraded degrades enhancing extracellular fibrils inflammasome ingests interacts knockout lysosomal map1lc3b microglia microglial native nlr nlrp3 optineurin optn promising pyrin resultant
Tagcloud (Intersection) ?