FNIP1 and CUL2

Number of citations of the paper that reports this interaction (PubMedID 32941802)
0

Data Source:
BioGRID (enzymatic study)

		FNIP1	CUL2
Description		folliculin interacting protein 1	cullin 2
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GO Annotations	Cellular Component	Cytoplasm Lysosome Lysosomal Membrane Cytosol Membrane	Nucleus Nucleoplasm Nucleolus Cytosol SCF Ubiquitin Ligase Complex Cullin-RING Ubiquitin Ligase Complex Cul2-RING Ubiquitin Ligase Complex Nuclear Lumen
	Molecular Function	Protein Binding Enzyme Activator Activity Enzyme Binding ATPase Inhibitor Activity Metal Ion Binding Protein-folding Chaperone Binding	Ubiquitin-protein Transferase Activity Protein Binding Protein-macromolecule Adaptor Activity Ubiquitin Protein Ligase Binding Ubiquitin Ligase Complex Scaffold Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II B Cell Apoptotic Process Immature B Cell Differentiation Positive Regulation Of B Cell Apoptotic Process Lysosome Organization Negative Regulation Of Cell Population Proliferation Cellular Response To Starvation B Cell Differentiation SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein-containing Complex Assembly Protein Destabilization Cellular Response To Nutrient Levels TOR Signaling Negative Regulation Of TOR Signaling Positive Regulation Of TOR Signaling TORC1 Signaling Negative Regulation Of Protein Localization To Nucleus Positive Regulation Of TORC1 Signaling Negative Regulation Of Lysosome Organization Regulation Of Pro-B Cell Differentiation	G1/S Transition Of Mitotic Cell Cycle Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Protein Ubiquitination Protein Catabolic Process SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Intrinsic Apoptotic Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Via The C-end Degron Rule Pathway
Pathways		Amino acids regulate mTORC1	Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Neddylation Regulation of expression of SLITs and ROBOs Antigen processing: Ubiquitination & Proteasome degradation Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 34315874) Alzheimer's disease in APOE e4- carriers ( 25778476) Aspartate aminotransferase levels ( 34315874) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Diisocyanate-induced asthma ( 25918132) Eosinophil count ( 27863252) Inflammatory bowel disease ( 28067908) Itch intensity from mosquito bite ( 28199695) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Mosquito bite size ( 28199695) Subcortical volume (MOSTest) ( 32665545) Sum eosinophil basophil counts ( 27863252) Systemic lupus erythematosus ( 33272962) Ulcerative colitis ( 28067908)	Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908)
Interacting Genes		4 interacting genes: CFTR CUL2 HSP90AA1 PRKAA1	28 interacting genes: ARID1B CAND1 CDC34 COMMD1 COPS5 DCUN1D2 DCUN1D3 DCUN1D4 DCUN1D5 E2F1 ELOC FNIP1 GPS1 KAT2A KHNYN MKNK2 NEDD8 RNF7 SAP130 SENP8 TRIP12 UBC UBE2D1 UBE2D3 UBE2M VHL ZER1 ZYG11B
Entrez ID		96459	8453
HPRD ID		17233	06786
Ensembl ID		ENSG00000217128	ENSG00000108094
Uniprot IDs		J3KNG8 Q8TF40	A0A0A0MTN0 A0A140VKB1 A0A8I5KVR3 B7Z1Y1 Q13617
PDB IDs		8JE2	4WQO 5N4W 6R6H 6R7F 6R7H 6R7I 6R7N 7PLO 8IJ1 8JAL 8JAQ 8JAR 8JAS 8JAU 8JAV 8JE1 8JE2 8PQL 8Q7R 8QU8 8R5H 8RWZ 8RX0 8WDK 8WQA 8WQB 8WQC 8WQE 8WQF 8WQG 8WQH
Enriched GO Terms of Interacting Partners?		Cholesterol Biosynthetic Process Apical Plasma Membrane Sterol Biosynthetic Process Positive Regulation Of Establishment Of Protein Localization Response To Cold Tau Protein Binding Positive Regulation Of Protein Localization SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Response To Estrogen Regulation Of Establishment Of Protein Localization Steroid Biosynthetic Process Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Response To Alkaloid CTP Binding DATP Binding Protein Catabolic Process Negative Regulation Of Glucosylceramide Biosynthetic Process Cholesterol Metabolic Process Sterol Metabolic Process Protein-containing Complex Response To Purine-containing Compound Positive Regulation Of Anion Channel Activity Neurofibrillary Tangle Assembly UTP Binding Response To Temperature Stimulus Sulfonylurea Receptor Binding Histone H2BS36 Kinase Activity [hydroxymethylglutaryl-CoA Reductase (NADPH)] Kinase Activity Regulation Of Protein Localization To Nucleus Regulation Of Protein Localization Positive Regulation Of Monoatomic Anion Transport Rho GDP-dissociation Inhibitor Binding Cold Acclimation Positive Regulation Of Mitochondrial Transcription Macromolecule Catabolic Process Positive Regulation Of Enamel Mineralization Protein Localization To Lipid Droplet Response To Ketone Transepithelial Water Transport Steroid Metabolic Process Basolateral Plasma Membrane Sperm Mitochondrial Sheath Protein Stabilization Negative Regulation Of Ceramide Biosynthetic Process Positive Regulation Of Tooth Mineralization Response To Alcohol Positive Regulation Of Protein Transport Telomerase Holoenzyme Complex Assembly	Protein Neddylation Post-translational Protein Modification Protein Modification By Small Protein Conjugation Regulation Of Protein Neddylation Protein Modification Process Ubiquitin-like Protein Binding Positive Regulation Of Protein Neddylation Protein Metabolic Process Cullin Family Protein Binding Proteolysis Involved In Protein Catabolic Process Regulation Of Post-translational Protein Modification Proteolysis Cul2-RING Ubiquitin Ligase Complex Regulation Of Primary Metabolic Process Ubiquitin Ligase Complex Nucleus Modification-dependent Protein Catabolic Process Positive Regulation Of Post-translational Protein Modification Macromolecule Metabolic Process Protein Ubiquitination Ubiquitin Conjugating Enzyme Binding Regulation Of Macromolecule Metabolic Process Protein Deneddylation Ubiquitin-dependent Protein Catabolic Process Regulation Of Metabolic Process Regulation Of Protein Modification Process Nucleoplasm Regulation Of Protein Metabolic Process Positive Regulation Of Protein Modification Process Regulation Of Transcription By RNA Polymerase II Ubiquitin-protein Transferase Activity Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Protein Metabolic Process Macromolecule Catabolic Process NEDD8 Transferase Activity Ubiquitin Conjugating Enzyme Activity Proteasomal Protein Catabolic Process Positive Regulation Of Metabolic Process DeNEDDylase Activity Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Protein Catabolic Process Protein Polyubiquitination Regulation Of G1/S Transition Of Mitotic Cell Cycle Protein Tag Activity
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