FNIP1

Description		folliculin interacting protein 1
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GO Annotations	Cellular Component	Cytoplasm Lysosome Lysosomal Membrane Cytosol Membrane
	Molecular Function	Protein Binding Enzyme Activator Activity Enzyme Binding ATPase Inhibitor Activity Metal Ion Binding Protein-folding Chaperone Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II B Cell Apoptotic Process Immature B Cell Differentiation Positive Regulation Of B Cell Apoptotic Process Lysosome Organization Negative Regulation Of Cell Population Proliferation Cellular Response To Starvation B Cell Differentiation SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein-containing Complex Assembly Protein Destabilization Cellular Response To Nutrient Levels TOR Signaling Negative Regulation Of TOR Signaling Positive Regulation Of TOR Signaling TORC1 Signaling Negative Regulation Of Protein Localization To Nucleus Positive Regulation Of TORC1 Signaling Negative Regulation Of Lysosome Organization Regulation Of Pro-B Cell Differentiation
Pathways		Amino acids regulate mTORC1
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 34315874) Alzheimer's disease in APOE e4- carriers ( 25778476) Aspartate aminotransferase levels ( 34315874) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Diisocyanate-induced asthma ( 25918132) Eosinophil count ( 27863252) Inflammatory bowel disease ( 28067908) Itch intensity from mosquito bite ( 28199695) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Mosquito bite size ( 28199695) Subcortical volume (MOSTest) ( 32665545) Sum eosinophil basophil counts ( 27863252) Systemic lupus erythematosus ( 33272962) Ulcerative colitis ( 28067908)
Interacting Genes		4 interacting genes: CFTR CUL2 HSP90AA1 PRKAA1
Entrez ID		96459
HPRD ID		17233
Ensembl ID		ENSG00000217128
Uniprot IDs		J3KNG8 Q8TF40
PDB IDs		8JE2
Enriched GO Terms of Interacting Partners?		Cholesterol Biosynthetic Process Apical Plasma Membrane Sterol Biosynthetic Process Positive Regulation Of Establishment Of Protein Localization Response To Cold Tau Protein Binding Positive Regulation Of Protein Localization SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Response To Estrogen Regulation Of Establishment Of Protein Localization Steroid Biosynthetic Process Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Response To Alkaloid CTP Binding DATP Binding Protein Catabolic Process Negative Regulation Of Glucosylceramide Biosynthetic Process Cholesterol Metabolic Process Sterol Metabolic Process Protein-containing Complex Response To Purine-containing Compound Positive Regulation Of Anion Channel Activity Neurofibrillary Tangle Assembly UTP Binding Response To Temperature Stimulus Sulfonylurea Receptor Binding Histone H2BS36 Kinase Activity [hydroxymethylglutaryl-CoA Reductase (NADPH)] Kinase Activity Regulation Of Protein Localization To Nucleus Regulation Of Protein Localization Positive Regulation Of Monoatomic Anion Transport Rho GDP-dissociation Inhibitor Binding Cold Acclimation Positive Regulation Of Mitochondrial Transcription Macromolecule Catabolic Process Positive Regulation Of Enamel Mineralization Protein Localization To Lipid Droplet Response To Ketone Transepithelial Water Transport Steroid Metabolic Process Basolateral Plasma Membrane Sperm Mitochondrial Sheath Protein Stabilization Negative Regulation Of Ceramide Biosynthetic Process Positive Regulation Of Tooth Mineralization Response To Alcohol Positive Regulation Of Protein Transport Telomerase Holoenzyme Complex Assembly
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