TBC1D25 and HMGB2

Number of citations of the paper that reports this interaction (PubMedID 32867128)
136

Data Source:
BioGRID (two hybrid)

		TBC1D25	HMGB2
Description		TBC1 domain family member 25	high mobility group box 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Autophagosome Cytoplasmic Vesicle	Chromatin Condensed Chromosome Extracellular Region Extracellular Space Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm Protein-containing Complex Perinuclear Region Of Cytoplasm
	Molecular Function	GTPase Activator Activity Protein Binding	Four-way Junction DNA Binding Transcription Cis-regulatory Region Binding Cis-regulatory Region Sequence-specific DNA Binding DNA Binding Damaged DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding Transcription Coactivator Activity RNA Binding Protein Binding Transcription Factor Binding DNA Binding, Bending Protein Domain Specific Binding Chemoattractant Activity Non-sequence-specific DNA Binding, Bending RAGE Receptor Binding Supercoiled DNA Binding DNA-binding Transcription Factor Binding
	Biological Process	Autophagy Regulation Of Autophagosome Maturation	Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Endothelial Cell Proliferation Immune System Process Inflammatory Response To Antigenic Stimulus DNA Topological Change Double-strand Break Repair Via Nonhomologous End Joining DNA Recombination Chromatin Organization Nucleosome Assembly Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Chemotaxis Inflammatory Response Spermatogenesis Spermatid Nucleus Differentiation Male Gonad Development Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression DNA Geometric Change Response To Lipopolysaccharide Positive Regulation Of Interferon-beta Production V(D)J Recombination Innate Immune Response Positive Regulation Of Innate Immune Response Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Megakaryocyte Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Response To Steroid Hormone Regulation Of Neurogenesis Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Positive Chemotaxis Cell Chemotaxis Cellular Response To Lipopolysaccharide Regulation Of Stem Cell Proliferation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Hemopoiesis
Pathways		TBC/RABGAPs	Apoptosis induced DNA fragmentation
Drugs
Diseases
GWAS
Interacting Genes		17 interacting genes: FAM9B FEZ1 FEZ2 GABARAP GABARAPL1 GABARAPL2 HMGB2 KCNIP1 LARP1B LGALS14 LMNTD2 MAP1LC3A MAP1LC3B MAP1LC3C RAB2A RUSC1 TRIML2	54 interacting genes: - APEX1 APP AR ARCN1 BCCIP C1QBP CACTIN CEBPA CHAF1A COMMD1 CRBN CREBBP CSNK1A1 EIF1 FBXO7 FLNA GZMA GZMK H3-3A HACD3 HDLBP HMGA1 LZTS1 MIEN1 MYL6 NAP1L1 NCBP3 NEXN NOP53 NR3C1 PCBP1 PGR PKNOX1 POU2F1 POU2F2 POU3F1 POU5F1 PRKDC RAG1 ROCK1 RPS28 SAMM50 SET SNAPIN TBC1D25 TP53 TSNAX U2AF1 UHRF2 ZFR ZNF428 ZNF622 ZNF668
Entrez ID		4943	3148
HPRD ID		08948	01229
Ensembl ID		ENSG00000068354	ENSG00000164104
Uniprot IDs		B4DF03 Q3MII6	P26583
PDB IDs
Enriched GO Terms of Interacting Partners?		Cellular Response To Nitrogen Starvation Phosphatidylethanolamine Binding Autophagosome Membrane Autophagosome Maturation Mitophagy Autophagy Of Mitochondrion Macroautophagy Autophagosome Autophagosome Assembly Autophagosome Organization Phospholipid Binding Protein-containing Complex Disassembly Autophagy Vacuole Organization Cellular Response To Starvation Microtubule Response To Starvation Cellular Response To Nutrient Levels Ubiquitin Protein Ligase Binding GABA Receptor Binding Cytoplasmic Vesicle Organelle Assembly Response To Nutrient Levels Beta-tubulin Binding Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Organelle Membrane Cytoskeleton Organelle Organization Negative Regulation Of Autophagosome Assembly Cellular Response To Stress Microtubule Binding Endomembrane System Positive Regulation Of Protein Polyubiquitination Transcription Factor Binding Extrinsic Apoptotic Signaling Pathway Cytoplasm Protein-containing Complex Organization Regulation Of Protein Polyubiquitination Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Catabolic Process Gamma-tubulin Binding Negative Regulation Of Macroautophagy Positive Regulation Of Interferon-beta Production Positive Regulation Of Anterograde Axonal Transport Of Mitochondrion Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Autophagosome Assembly Cellular Component Assembly Regulation Of Interferon-beta Production Golgi Apparatus Regulation Of Vacuole Organization	Nucleus RNA Binding Nucleic Acid Metabolic Process Regulation Of MiRNA Transcription DNA Metabolic Process Regulation Of MiRNA Metabolic Process DNA Binding Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Chromatin Sequence-specific DNA Binding Regulation Of Metabolic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process DNA Repair Transcription Coactivator Binding Negative Regulation Of Biosynthetic Process Positive Regulation Of MiRNA Transcription Transcription Regulator Complex Regulation Of Apoptotic Process Chromatin Organization Positive Regulation Of MiRNA Metabolic Process Regulation Of Programmed Cell Death Chromatin Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase I Regulation Of Macromolecule Metabolic Process Regulation Of RNA Metabolic Process Estrogen Response Element Binding Regulation Of Gene Expression Nucleoplasm Cytoplasm Chromatin Remodeling Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Nuclear Speck Negative Regulation Of DNA-templated Transcription Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Neuron Apoptotic Process Regulation Of Protein Stability Negative Regulation Of RNA Metabolic Process
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?