SEC24C and WIPF1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		SEC24C	WIPF1
Description		SEC24 homolog C, COPII component	WAS/WASL interacting protein family member 1
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GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol ER To Golgi Transport Vesicle Membrane Membrane COPII Vesicle Coat Cytoplasmic Vesicle Endoplasmic Reticulum Exit Site	Ruffle Cytoplasm Cytosol Cytoskeleton Actin Filament Actin Cytoskeleton Cytoplasmic Vesicle Cell Projection
	Molecular Function	SNARE Binding Protein Binding Zinc Ion Binding Metal Ion Binding	Actin Binding Protein Binding Profilin Binding Cytoskeletal Anchor Activity SH3 Domain Binding Protein Folding Chaperone
	Biological Process	In Utero Embryonic Development Intracellular Protein Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Protein Transport Vesicle-mediated Transport COPII-coated Vesicle Cargo Loading	Protein Folding Actin Polymerization Or Depolymerization Actin Filament-based Process Actin Filament-based Movement Response To Other Organism Protein-containing Complex Assembly
Pathways		Regulation of cholesterol biosynthesis by SREBP (SREBF) COPII-mediated vesicle transport MHC class II antigen presentation Cargo concentration in the ER SARS-CoV-2 activates/modulates innate and adaptive immune responses Antigen Presentation: Folding, assembly and peptide loading of class I MHC	Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs CDC42 GTPase cycle RAC1 GTPase cycle FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis
Drugs
Diseases
GWAS		Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Crohn's disease ( 28067908) Lung function (FEV1) ( 30175238) Self-rated health ( 27864402)	Atrial fibrillation ( 29892015 30061737) Mean platelet volume ( 32888494) Platelet distribution width ( 32888494) Pulse pressure ( 27841878) Resting heart rate ( 27798624) Systolic blood pressure ( 27841878) Urate levels (BMI interaction) ( 25811787)
Interacting Genes		10 interacting genes: APP CRYAA FBXO7 MIA2 MIA3 MOS SEC23A SEC23B SPP1 WIPF1	26 interacting genes: ABI2 ACTC1 ACTG1 ALAS1 APBB1 CACNG2 CDC42 CEBPA CRKL CTTN FASTK GRB2 HCK HOMER3 ITSN2 NCK1 PRKCQ PRPF40A RER1 SEC24C SH3RF1 WAS WASL WBP4 WWP2 ZAP70
Entrez ID		9632	7456
HPRD ID		06217	03835
Ensembl ID		ENSG00000176986	ENSG00000115935
Uniprot IDs		P53992	A0A140VJZ9 E9PB87 O43516 Q2YDC4
PDB IDs		3EH2 6PU1 8CL3	2A41 9EZN 9EZO 9EZP
Enriched GO Terms of Interacting Partners?		Vesicle Cargo Loading Endoplasmic Reticulum Exit Site COPII-coated Vesicle Cargo Loading Endoplasmic Reticulum To Golgi Vesicle-mediated Transport COPII-coated Vesicle Budding Protein Localization To Endoplasmic Reticulum Exit Site Golgi Vesicle Transport Lipoprotein Transport Protein Localization To Endoplasmic Reticulum COPII Vesicle Coat Establishment Of Localization In Cell Cargo Receptor Activity Vesicle Budding From Membrane Vesicle-mediated Transport Intracellular Transport Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Perinuclear Region Of Cytoplasm Amylin Binding Positive Regulation Of Toll Signaling Pathway Endoplasmic Reticulum Lumen Establishment Of Protein Localization Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury ER To Golgi Transport Vesicle Membrane Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Regulation Of Lymphocyte Migration Cellular Localization Endoplasmic Reticulum Cytoplasmic Vesicle Acetylcholine Receptor Activator Activity Lipoprotein Particle Positive Regulation Of Protein Import Positive Regulation Of Estradiol Secretion PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Negative Regulation Of Metaphase/anaphase Transition Of Meiotic Cell Cycle Regulation Of Estradiol Secretion Lewy Body Core Response To Norepinephrine	Actin Filament Regulation Of Actin Filament Organization Regulation Of Actin Cytoskeleton Organization Regulation Of Actin Filament-based Process Regulation Of Supramolecular Fiber Organization Cell Motility Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Cytoskeleton Organization Lamellipodium Cell-cell Junction Phosphotyrosine Residue Binding Positive Regulation Of Actin Filament Polymerization Regulation Of Cytoskeleton Organization Actin Filament-based Process Actin Filament Organization Proline-rich Region Binding Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Cell Projection Morphogenesis Immune Response-regulating Cell Surface Receptor Signaling Pathway Cell Migration Cytosol Regulation Of Cell Projection Organization Positive Regulation Of Protein Polymerization Positive Regulation Of Organelle Organization Positive Regulation Of Cellular Component Biogenesis Actin Cytoskeleton Organization Dendritic Spine Organization Cell Projection Organization Regulation Of Cell Projection Assembly Regulation Of Lamellipodium Assembly Vesicle Membrane Regulation Of Cellular Component Organization Positive Regulation Of Cellular Component Organization Intracellular Signaling Cassette Immune Response-regulating Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Neuron Projection Organization Regulation Of Cellular Component Size Regulation Of Actin Filament Polymerization Postsynapse Organization Neuron Projection Morphogenesis Regulation Of Organelle Organization Regulation Of Plasma Membrane Bounded Cell Projection Organization Small GTPase-mediated Signal Transduction Cell Junction Organization Peptidyl-tyrosine Phosphorylation Regulation Of Lamellipodium Organization Regulation Of Immune System Process Antigen Receptor-mediated Signaling Pathway
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