SEC24C and MIA3

Number of citations of the paper that reports this interaction (PubMedID 19269366)
0

Data Source:
BioGRID (two hybrid)

		SEC24C	MIA3
Description		SEC24 homolog C, COPII component	MIA SH3 domain ER export factor 3
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GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol ER To Golgi Transport Vesicle Membrane Membrane COPII Vesicle Coat Cytoplasmic Vesicle Endoplasmic Reticulum Exit Site	Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Membrane Endoplasmic Reticulum Exit Site
	Molecular Function	SNARE Binding Protein Binding Zinc Ion Binding Metal Ion Binding	Protein Binding Cargo Receptor Activity
	Biological Process	In Utero Embryonic Development Intracellular Protein Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Protein Transport Vesicle-mediated Transport COPII-coated Vesicle Cargo Loading	Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Leukocyte Migration Exocytosis Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Endoplasmic Reticulum Organization Negative Regulation Of Cell Adhesion Protein Secretion Protein Transport Vesicle-mediated Transport Negative Regulation Of Cell Migration Vesicle Cargo Loading Wound Healing Lipoprotein Transport System Development Protein Localization To Endoplasmic Reticulum Exit Site COPII-coated Vesicle Cargo Loading Cellular Response To Oxidised Low-density Lipoprotein Particle Stimulus Negative Regulation Of Leukocyte Cell-cell Adhesion Negative Regulation Of Lymphocyte Migration
Pathways		Regulation of cholesterol biosynthesis by SREBP (SREBF) COPII-mediated vesicle transport MHC class II antigen presentation Cargo concentration in the ER SARS-CoV-2 activates/modulates innate and adaptive immune responses Antigen Presentation: Folding, assembly and peptide loading of class I MHC	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Cargo concentration in the ER Post-translational protein phosphorylation
Drugs
Diseases
GWAS		Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Crohn's disease ( 28067908) Lung function (FEV1) ( 30175238) Self-rated health ( 27864402)	Coronary artery disease ( 26343387 29212778 32469254 33020668) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary heart disease ( 17634449 21378990) Myocardial infarction ( 26343387 33532862) Myocardial infarction (early onset) ( 19198609)
Interacting Genes		10 interacting genes: APP CRYAA FBXO7 MIA2 MIA3 MOS SEC23A SEC23B SPP1 WIPF1	17 interacting genes: CACNA1A CEP55 CLIC3 COL7A1 FXR2 HOMER3 HSD17B14 ITGAX LENG8 MTNR1B NCK2 PRDM14 SEC16A SEC23A SEC24C TRIM27 UBC
Entrez ID		9632	375056
HPRD ID		06217	18918
Ensembl ID		ENSG00000176986	ENSG00000154305
Uniprot IDs		P53992	Q5JRA6
PDB IDs		3EH2 6PU1 8CL3	5KYN 5KYU 5KYW 7R3M
Enriched GO Terms of Interacting Partners?		Vesicle Cargo Loading Endoplasmic Reticulum Exit Site COPII-coated Vesicle Cargo Loading Endoplasmic Reticulum To Golgi Vesicle-mediated Transport COPII-coated Vesicle Budding Protein Localization To Endoplasmic Reticulum Exit Site Golgi Vesicle Transport Lipoprotein Transport Protein Localization To Endoplasmic Reticulum COPII Vesicle Coat Establishment Of Localization In Cell Cargo Receptor Activity Vesicle Budding From Membrane Vesicle-mediated Transport Intracellular Transport Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Perinuclear Region Of Cytoplasm Amylin Binding Positive Regulation Of Toll Signaling Pathway Endoplasmic Reticulum Lumen Establishment Of Protein Localization Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury ER To Golgi Transport Vesicle Membrane Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Regulation Of Lymphocyte Migration Cellular Localization Endoplasmic Reticulum Cytoplasmic Vesicle Acetylcholine Receptor Activator Activity Lipoprotein Particle Positive Regulation Of Protein Import Positive Regulation Of Estradiol Secretion PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Negative Regulation Of Metaphase/anaphase Transition Of Meiotic Cell Cycle Regulation Of Estradiol Secretion Lewy Body Core Response To Norepinephrine	Endoplasmic Reticulum Exit Site ER To Golgi Transport Vesicle Membrane COPII Vesicle Coat COPII-coated Vesicle Cargo Loading Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Vesicle Cargo Loading
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