SEC24C and SEC23A

Number of citations of the paper that reports this interaction (PubMedID 10075675)
0

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		SEC24C	SEC23A
Description		SEC24 homolog C, COPII component	SEC23 homolog A, COPII component
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GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol ER To Golgi Transport Vesicle Membrane Membrane COPII Vesicle Coat Cytoplasmic Vesicle Endoplasmic Reticulum Exit Site	Golgi Membrane Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol ER To Golgi Transport Vesicle Membrane Membrane COPII Vesicle Coat COPII-coated ER To Golgi Transport Vesicle Cytoplasmic Vesicle Perinuclear Region Of Cytoplasm Endoplasmic Reticulum Exit Site
	Molecular Function	SNARE Binding Protein Binding Zinc Ion Binding Metal Ion Binding	GTPase Activator Activity Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	In Utero Embryonic Development Intracellular Protein Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Protein Transport Vesicle-mediated Transport COPII-coated Vesicle Cargo Loading	Intracellular Protein Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Protein Transport Vesicle-mediated Transport Protein Localization To Plasma Membrane COPII-coated Vesicle Cargo Loading COPII-coated Vesicle Budding
Pathways		Regulation of cholesterol biosynthesis by SREBP (SREBF) COPII-mediated vesicle transport MHC class II antigen presentation Cargo concentration in the ER SARS-CoV-2 activates/modulates innate and adaptive immune responses Antigen Presentation: Folding, assembly and peptide loading of class I MHC	Regulation of cholesterol biosynthesis by SREBP (SREBF) COPII-mediated vesicle transport MHC class II antigen presentation Cargo concentration in the ER SARS-CoV-2 activates/modulates innate and adaptive immune responses Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Drugs
Diseases			Cranio-lenticulo-sutural dysplasia (CLSD); Boyadjiev-Jabs syndrome
GWAS		Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Crohn's disease ( 28067908) Lung function (FEV1) ( 30175238) Self-rated health ( 27864402)	Metabolite levels ( 23823483) Vitamin D levels ( 29343764)
Interacting Genes		10 interacting genes: APP CRYAA FBXO7 MIA2 MIA3 MOS SEC23A SEC23B SPP1 WIPF1	33 interacting genes: BNIP3 CADPS CDK16 CDK18 CLEC17A DCTN1 DNM2 DTX2 ERGIC3 ERLIN1 FASLG FATE1 GJA8 GLRA2 HOMEZ MFF MIA2 MIA3 MINAR1 NDRG1 PIAS2 RNF19B SDCBP2 SEC16A SEC23IP SEC24B SEC24C SF1 SLC7A1 SUCLA2 TMEM45B TNFSF14 WBP11
Entrez ID		9632	10484
HPRD ID		06217	06714
Ensembl ID		ENSG00000176986	ENSG00000100934
Uniprot IDs		P53992	Q15436
PDB IDs		3EH2 6PU1 8CL3	2NUP 2NUT 2YRC 2YRD 3EFO 3EG9 3EGD 3EGX 5KYN 5KYU 5KYW 5KYX 5KYY 5VNE 5VNF 5VNG 5VNH 5VNI 5VNJ 5VNK 5VNL 5VNM 5VNN 5VNO 8HR0
Enriched GO Terms of Interacting Partners?		Vesicle Cargo Loading Endoplasmic Reticulum Exit Site COPII-coated Vesicle Cargo Loading Endoplasmic Reticulum To Golgi Vesicle-mediated Transport COPII-coated Vesicle Budding Protein Localization To Endoplasmic Reticulum Exit Site Golgi Vesicle Transport Lipoprotein Transport Protein Localization To Endoplasmic Reticulum COPII Vesicle Coat Establishment Of Localization In Cell Cargo Receptor Activity Vesicle Budding From Membrane Vesicle-mediated Transport Intracellular Transport Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Perinuclear Region Of Cytoplasm Amylin Binding Positive Regulation Of Toll Signaling Pathway Endoplasmic Reticulum Lumen Establishment Of Protein Localization Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury ER To Golgi Transport Vesicle Membrane Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Regulation Of Lymphocyte Migration Cellular Localization Endoplasmic Reticulum Cytoplasmic Vesicle Acetylcholine Receptor Activator Activity Lipoprotein Particle Positive Regulation Of Protein Import Positive Regulation Of Estradiol Secretion PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Negative Regulation Of Metaphase/anaphase Transition Of Meiotic Cell Cycle Regulation Of Estradiol Secretion Lewy Body Core Response To Norepinephrine	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Endoplasmic Reticulum Exit Site Golgi Vesicle Transport Protein Localization To Endoplasmic Reticulum Exit Site Vesicle Cargo Loading Protein Localization To Endoplasmic Reticulum ER To Golgi Transport Vesicle Membrane COPII-coated Vesicle Cargo Loading Vesicle-mediated Transport Membrane Establishment Of Localization In Cell Endoplasmic Reticulum Membrane Endoplasmic Reticulum Cytoplasmic Vesicle Intracellular Transport Regulation Of Plasma Membrane Organization COPII Vesicle Coat Lipoprotein Transport Establishment Of Protein Localization Positive Regulation Of Mitochondrial Fission Mitochondrial Calcium Ion Homeostasis Cell Morphogenesis Involved In Neuron Differentiation Protein Transport
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