OPRL1 and RGS19

Number of citations of the paper that reports this interaction (PMID 11090272)
7

Data Source:
HPRD (in vitro, in vivo)

		OPRL1	RGS19
Gene Name		opiate receptor-like 1	regulator of G-protein signaling 19
Image
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Cytoplasmic Membrane-bounded Vesicle Neuron Projection	Cytoplasm Golgi Apparatus Heterotrimeric G-protein Complex Plasma Membrane Brush Border Membrane Clathrin-coated Vesicle
	Molecular Function	Nociceptin Receptor Activity G-protein Coupled Receptor Activity Protein Binding Neuropeptide Binding	G-protein Alpha-subunit Binding GTPase Activator Activity Protein Binding
	Biological Process	Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Neuropeptide Signaling Pathway Synaptic Transmission Sensory Perception Behavior Sensory Perception Of Pain Opioid Receptor Signaling Pathway	Autophagy G-protein Coupled Receptor Signaling Pathway Small GTPase Mediated Signal Transduction Termination Of G-protein Coupled Receptor Signaling Pathway Positive Regulation Of GTPase Activity
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding	G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Gastrin-CREB signalling pathway via PKC and MAPK G alpha (z) signalling events G alpha (i) signalling events
Drugs
Diseases
GWAS
Protein-Protein Interactions		4 interactors: GNA14 GPRASP1 PNOC RGS19	15 interactors: CSNK2A1 CSNK2A2 GDE1 GIPC1 GNAI1 GNAI2 GNAI3 GNAO1 GNAZ MAPK1 MAPK6 OPRL1 OSTM1 PRKCA TGFBR1
Entrez ID		4987	10287
HPRD ID		03971	05461
Ensembl ID		ENSG00000125510	ENSG00000171700
Uniprot IDs		P41146	B4DP94 P49795
PDB IDs		4EA3	1CMZ
Enriched GO Terms of Interacting Partners?		Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway G-protein Coupled Receptor Catabolic Process Regulation Of G-protein Coupled Receptor Protein Signaling Pathway G-protein Coupled Receptor Signaling Pathway Phospholipase C-activating Dopamine Receptor Signaling Pathway Receptor Catabolic Process	Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Cell Surface Receptor Signaling Pathway Cell Cycle Synaptic Transmission Platelet Activation G-protein Coupled Receptor Signaling Pathway Signal Transduction Negative Regulation Of Adenylate Cyclase Activity Negative Regulation Of Lyase Activity Signaling Cell-cell Signaling Cell Communication Negative Regulation Of CAMP Biosynthetic Process Negative Regulation Of CAMP Metabolic Process Wound Healing Negative Regulation Of Nucleotide Metabolic Process Cell Activation Response To Wounding Peptidyl-threonine Phosphorylation Cellular Response To Stimulus Blood Coagulation Hemostasis Regulation Of Adenylate Cyclase Activity Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Activation Of MAPKK Activity Regulation Of Cyclase Activity Negative Regulation Of Cellular Protein Catabolic Process Regulation Of Body Fluid Levels Regulation Of CAMP Biosynthetic Process Regulation Of CAMP Metabolic Process Response To Stimulus Negative Regulation Of Protein Catabolic Process Peptidyl-serine Phosphorylation Locomotion Positive Regulation Of Signal Transduction Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Phosphorylation Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cell Proliferation Positive Regulation Of MAPK Cascade Movement Of Cell Or Subcellular Component Regulation Of Protein Metabolic Process Regulation Of Cell Cycle Regulation Of Proteasomal Protein Catabolic Process Apoptotic Process Programmed Cell Death Mitotic Spindle Checkpoint
Tagcloud ?			accelerating adenylate c6 cyclase dampen depressant galphai galphai2 gap gaps go gpcr gpcrs gtpase hairpin ht1a implicating insensitive medications mood neuroblastoma postsynaptic prefrontal raphe shrna sy5y synergy viable
Tagcloud (Difference) ?			accelerating adenylate c6 cyclase dampen depressant galphai galphai2 gap gaps go gpcr gpcrs gtpase hairpin ht1a implicating insensitive medications mood neuroblastoma postsynaptic prefrontal raphe shrna sy5y synergy viable
Tagcloud (Intersection) ?